Itanistomig

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 16:26:28 GMT 2025` Edited by `admin` on `Wed Apr 02 16:26:28 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	ZCV7SK2URC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Fused heavy chain (VH anti-CD274 -G1CH1-h)-H-gamma1 anti-CD47 (1-683) [(VH-G1CH1-h) chain anti-CD274, Homo sapiens (1-226) [(VH (Homo sapiens IGHV1-69*01 (93.9%) -(IGHD) -IGHJ6*01 (93.8%), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1-123) -Homo sapiens IGH

Preferred Name

English

Itanistomig

Official Name

English

itanistomig [INN]

Common Name

English

Immunoglobulin (VH-G1CH1-h)-H-gamma1_L-kappa-L-kappa, anti-[Homo sapiens CD274 (programmed cell death 1 ligand 1, PDL1, PD-L1, B7 homolog 1, B7H1, B7-H1, PDCD1LG1)] and anti-[Homo sapiens CD47 (CD47 molecule, integrin associated protein, IAP, MER6, OA3)]

Common Name

English

Code System Code Type Description

SMS_ID

300000056808

Created by admin on Wed Apr 02 16:26:28 GMT 2025 , Edited by admin on Wed Apr 02 16:26:28 GMT 2025

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INN

13139

Created by admin on Wed Apr 02 16:26:28 GMT 2025 , Edited by admin on Wed Apr 02 16:26:28 GMT 2025

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CAS

2923687-56-1

Created by admin on Wed Apr 02 16:26:28 GMT 2025 , Edited by admin on Wed Apr 02 16:26:28 GMT 2025

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NCI_THESAURUS

C200549

Created by admin on Wed Apr 02 16:26:28 GMT 2025 , Edited by admin on Wed Apr 02 16:26:28 GMT 2025

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FDA UNII

ZCV7SK2URC

Created by admin on Wed Apr 02 16:26:28 GMT 2025 , Edited by admin on Wed Apr 02 16:26:28 GMT 2025

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From	To
2_456	4_443
1_456	3_443
2_226	4_213
1_226	3_213
4_363	4_423
4_247	4_317
4_133	4_193
4_23	4_88
3_363	3_423
3_247	3_317
3_133	3_193
3_23	3_88
2_603	2_661
2_497	2_557
2_380	2_436
2_259	2_333
2_150	2_206
2_22	2_96
1_603	1_661
1_497	1_557
1_465	2_465
1_462	2_462
1_380	1_436
1_259	1_333
1_150	1_206
1_22	1_96

Glycosylation Link Type	Site
N	1_533
N	2_533

Related Record Type Details


					ZCV7SK2URC

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_683] [2_683]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL