ZIMBERELIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 23:00:58 GMT 2025` Edited by `admin` on `Tue Apr 01 23:00:58 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	ZBL7O904IL
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ZIMBERELIMAB

Official Name

English

AB-122

Preferred Name

English

AB122

Code

English

WBP3055

Code

English

ZIMBERELIMAB [USAN]

Common Name

English

ANTI-PD-1 MONOCLONAL ANTIBODY GLS-010

Common Name

English

IMMUNOGLOBULIN G4(231-PROLINE), ANTI-(HUMAN PROGRAMMED CELL DEATH PROTEIN 1) (HUMAN MONOCLONAL AB122 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL AB122 .LAMBDA.-CHAIN, DIMER

Common Name

English

WBP-3055

Code

English

IMMUNOGLOBULIN G4-LAMBDA, ANTI-(HOMO SAPIENS PROGRAMMED CELL DEATH PROTEIN 1 (HPD-1, CD279-ANTIGEN)); HOMO SAPIENS MONOCLONAL ANTIBODY; .GAMMA.4 HEAVY CHAIN HOMO SAPIENS (1-450) (VH (HOMO SAPIENS IGHV4-39*01 (88%) (IGHD)-IGHJ4*01) (10.7.15) (1-123)-HOMO

Common Name

English

GLS-010

Code

English

zimberelimab [INN]

Common Name

English

Zimberelimab [WHO-DD]

Common Name

English

Code System Code Type Description

USAN

HI-142

Created by admin on Tue Apr 01 23:00:58 GMT 2025 , Edited by admin on Tue Apr 01 23:00:58 GMT 2025

PRIMARY

INN

11413

Created by admin on Tue Apr 01 23:00:58 GMT 2025 , Edited by admin on Tue Apr 01 23:00:58 GMT 2025

PRIMARY

CAS

2259860-24-5

Created by admin on Tue Apr 01 23:00:58 GMT 2025 , Edited by admin on Tue Apr 01 23:00:58 GMT 2025

PRIMARY

SMS_ID

300000015760

Created by admin on Tue Apr 01 23:00:58 GMT 2025 , Edited by admin on Tue Apr 01 23:00:58 GMT 2025

PRIMARY

NCI_THESAURUS

C159549

Created by admin on Tue Apr 01 23:00:58 GMT 2025 , Edited by admin on Tue Apr 01 23:00:58 GMT 2025

PRIMARY

NCI_THESAURUS

C128037

Created by admin on Tue Apr 01 23:00:58 GMT 2025 , Edited by admin on Tue Apr 01 23:00:58 GMT 2025

CONCEPT

FDA UNII

ZBL7O904IL

Created by admin on Tue Apr 01 23:00:58 GMT 2025 , Edited by admin on Tue Apr 01 23:00:58 GMT 2025

PRIMARY

From	To
1_22	1_97
2_22	2_97
2_137	4_215
2_150	2_206
2_264	2_324
1_137	3_215
2_370	2_428
3_22	3_90
3_138	3_197
4_22	4_90
4_138	4_197
1_150	1_206
1_229	2_229
1_232	2_232
1_264	1_324
1_370	1_428

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					938DNF64FO

PROGRAMMED CELL DEATH PROTEIN 1

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					ZBL7O904IL

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1] [3_1] [4_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_450] [2_450]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL