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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 22:13:05 GMT 2025
Edited
by admin
on Tue Apr 01 22:13:05 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1|KAPPA
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
Z9U2SS9ZC8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AVE-1642
Preferred Name English
Veligrotug
INN  
Official Name English
Veligrotug [WHO-DD]
Common Name English
veligrotug [INN]
Common Name English
Immunoglobulin G1, anti-(human insulin-like growth factor I receptor) (human-Mus musculus monoclonal VRDN-001 ?1-chain), disulfide with human-Mus musculus monoclonal VRDN-001 ?-chain, dimer
Common Name English
VELIGROTUG [USAN]
Common Name English
ANTI-CD122 MONOCLONAL ANTIBODY AVE1642
Common Name English
ANTI-IGF-1R MONOCLONAL ANTIBODY AVE1642
Common Name English
Immunoglobulin G1-kappa, anti-[Homo sapiens IGF1R (insulin-like growth factor 1 receptor, IGF1-R, IGF-1R, CD221)], chimeric monoclonal antibody (gamma1 heavy chain chimeric (1-454) [VH (Mus musculus IGHV1S81*02 (91.8%) -(IGHD) -IGHJ1*01 (93.8%), CDR-IMGT
Common Name English
AVE1642
Code English
HUMANISED IgG1 KAPPA ANTI-INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR MONOCLONAL ANTIBODY VRDN-001
Common Name English
Code System Code Type Description
USAN
MN-133
Created by admin on Tue Apr 01 22:13:05 GMT 2025 , Edited by admin on Tue Apr 01 22:13:05 GMT 2025
PRIMARY
FDA UNII
Z9U2SS9ZC8
Created by admin on Tue Apr 01 22:13:05 GMT 2025 , Edited by admin on Tue Apr 01 22:13:05 GMT 2025
PRIMARY
CAS
2728655-31-8
Created by admin on Tue Apr 01 22:13:05 GMT 2025 , Edited by admin on Tue Apr 01 22:13:05 GMT 2025
PRIMARY
CAS
1242567-05-0
Created by admin on Tue Apr 01 22:13:05 GMT 2025 , Edited by admin on Tue Apr 01 22:13:05 GMT 2025
NO STRUCTURE GIVEN
INN
12548
Created by admin on Tue Apr 01 22:13:05 GMT 2025 , Edited by admin on Tue Apr 01 22:13:05 GMT 2025
PRIMARY
SMS_ID
300000041434
Created by admin on Tue Apr 01 22:13:05 GMT 2025 , Edited by admin on Tue Apr 01 22:13:05 GMT 2025
PRIMARY
NCI_THESAURUS
C79798
Created by admin on Tue Apr 01 22:13:05 GMT 2025 , Edited by admin on Tue Apr 01 22:13:05 GMT 2025
PRIMARY
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_304
N 2_304
Related Record Type Details
INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR
TARGET -> INHIBITOR
Related Record Type Details
Veligrotug
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID REMOVAL [1_454] [2_454] C-TERMINUS LYSINE K3Z4F929H6
AMINO_ACID_SUBSTITUTION [1_1] [2_1] N-TERMINUS PIDOLIC ACID SZB83O1W42
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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