PYROVALERONE HYDROCHLORIDE

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H23NO.ClH
Molecular Weight	281.821
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCCC(N1CCCC1)C(=O)C2=CC=C(C)C=C2

InChI

InChIKey=MWRACNBZNVAJHE-UHFFFAOYSA-N

InChI=1S/C16H23NO.ClH/c1-3-6-15(17-11-4-5-12-17)16(18)14-9-7-13(2)8-10-14;/h7-10,15H,3-6,11-12H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C16H23NO
Molecular Weight	245.3599
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5441133 | https://www.ncbi.nlm.nih.gov/pubmed/16480278 | (2014) Pediatric Trauma Care II, page 123, retrieved from: https://books.google.ru/books?id=9fucAwAAQBAJ

Pyrovalerone is a psychostimulant. It has a central action. Pyrovalerone inhibits the dopamine transporter and the norepinephrine transporter, and is a weak inhibitor of the serotonin transporter. Pyrovalerone was demonstrated to reduce symptoms of chronic fatigue in humans. It stimulated locomotor activity in mice. Though pyrovalerone is still occasionally prescribed, it is used infrequently due to problems with abuse and dependence. Side effects of pyrovalerone include anxiety, fragmented sleep or insomnia and trembling, shaking or muscle tremors.

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
Toxicological determination and in vitro metabolism of the designer drug methylenedioxypyrovalerone (MDPV) by gas chromatography/mass spectrometry and liquid chromatography/quadrupole time-of-flight mass spectrometry.	2010-09	20814976
Mass and NMR spectroscopic characterization of 3,4-methylenedioxypyrovalerone: a designer drug with alpha-pyrrolidinophenone structure.	2009-09-10	19500924
A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone.	2009-06-01	19442525
1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors.	2006-02-23	16480278
Differential sensitivity to NaCl for inhibitors and substrates that recognize mutually exclusive binding sites on the neuronal transporter of dopamine in rat striatal membranes.	2001-03	11248372

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:59:10 GMT 2025` Edited by `admin` on `Mon Mar 31 17:59:10 GMT 2025`
Record UNII	Z95Z9C2201
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CENTROTON

Preferred Name

English

PYROVALERONE HYDROCHLORIDE

Official Name

English

1-PENTANONE, 1-(4-METHYLPHENYL)-2-(1-PYRROLIDINYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

1-PENTANONE, 1-(4-METHYLPHENYL)-2-(1-PYRROLIDINYL)-, HYDROCHLORIDE

Systematic Name

English

PYROVALERONE HYDROCHLORIDE [USAN]

Common Name

English

THYMERGIX

Brand Name

English

PYROVALERONE HCL

Common Name

English

Pyrovalerone hydrochloride [WHO-DD]

Common Name

English

F 1983

Code

English

SP-1059

Code

English

1-(P-METHYLPHENYL)-2-PYRROLIDYL-1-PENTANONE HYDROCHLORIDE

Common Name

English

PYROVALERONE HYDROCHLORIDE [MI]

Common Name

English

F-1983

Code

English

4'-METHYL-2-(1-PYRROLIDINYL)VALEROPHENONE HYDROCHLORIDE

Systematic Name

English

VALEROPHENONE, 4'-METHYL-2-(1-PYRROLIDINYL)-, HYDROCHLORIDE

Systematic Name

English

Classification Tree Code System Code

DEA NO.

1485