FLORDIPINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H33F3N2O5
Molecular Weight	510.5458
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)C1=C(C)N(CCN2CCOCC2)C(C)=C(C1C3=C(C=CC=C3)C(F)(F)F)C(=O)OCC

InChI

InChIKey=RSXGUJLKWYUPMC-UHFFFAOYSA-N

InChI=1S/C26H33F3N2O5/c1-5-35-24(32)21-17(3)31(12-11-30-13-15-34-16-14-30)18(4)22(25(33)36-6-2)23(21)19-9-7-8-10-20(19)26(27,28)29/h7-10,23H,5-6,11-16H2,1-4H3

HIDE SMILES / InChI

Molecular Formula	C26H33F3N2O5
Molecular Weight	510.5458
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3327854

FLORDIPINE is a calcium channel blocker with a structure similar to that of nifedipine, and with similar cardiovascular effects. However, unlike nifedipine, FLORDIPINE requires hepatic metabolism for its activation.

Originator

Approval Year

PubMed

Title	Date	PubMed
Comparison of nifedipine with a new calcium channel blocker, flordipine, in exercise-induced asthma.	1987	3327854
Effects of calcium "antagonists" on vertebrate skeletal muscle cells.	1988	3259850
Flordipine, a calcium channel blocker, which does not influence lipidemia or atherosclerosis in cholesterol-fed rabbits.	1988 Jan	3355610

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:16:46 UTC 2023` Edited by `admin` on `Fri Dec 15 15:16:46 UTC 2023`
Record UNII	Z8UFI7XI7R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLORDIPINE

Official Name

English

FLORDIPINE [USAN]

Common Name

English

Flordipine [WHO-DD]

Common Name

English

DIETHYL 1,4-DIHYDRO-2,6-DIMETHYL-1-(2-(4-MORPHOLINYL)ETHYL)-4-(2-(TRIFLUOROMETHYL)PHENYL)-3,5-PYRIDINEDICARBOXYLATE

Systematic Name

English

3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-1-(2-(4-MORPHOLINYL)ETHYL)-4-(2-(TRIFLUOROMETHYL)PHENYL)-, DIETHYL ESTER

Common Name

English

flordipine [INN]

Common Name

English

RHC-2906

Code

English

RHC 2906

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C333