FLORDIPINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H33F3N2O5
Molecular Weight	510.5458
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)C1=C(C)N(CCN2CCOCC2)C(C)=C(C1C3=CC=CC=C3C(F)(F)F)C(=O)OCC

InChI

InChIKey=RSXGUJLKWYUPMC-UHFFFAOYSA-N

InChI=1S/C26H33F3N2O5/c1-5-35-24(32)21-17(3)31(12-11-30-13-15-34-16-14-30)18(4)22(25(33)36-6-2)23(21)19-9-7-8-10-20(19)26(27,28)29/h7-10,23H,5-6,11-16H2,1-4H3

HIDE SMILES / InChI

Molecular Formula	C26H33F3N2O5
Molecular Weight	510.5458
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3327854

FLORDIPINE is a calcium channel blocker with a structure similar to that of nifedipine, and with similar cardiovascular effects. However, unlike nifedipine, FLORDIPINE requires hepatic metabolism for its activation.

Originator

Approval Year

PubMed

Title	Date	PubMed
Flordipine, a calcium channel blocker, which does not influence lipidemia or atherosclerosis in cholesterol-fed rabbits.	1988-01	3355610
Effects of calcium "antagonists" on vertebrate skeletal muscle cells.	1988	3259850
Comparison of nifedipine with a new calcium channel blocker, flordipine, in exercise-induced asthma.	1987	3327854

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:52:40 GMT 2025` Edited by `admin` on `Mon Mar 31 17:52:40 GMT 2025`
Record UNII	Z8UFI7XI7R
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FLORDIPINE

Official Name

English

RHC 2906

Preferred Name

English

FLORDIPINE [USAN]

Common Name

English

Flordipine [WHO-DD]

Common Name

English

DIETHYL 1,4-DIHYDRO-2,6-DIMETHYL-1-(2-(4-MORPHOLINYL)ETHYL)-4-(2-(TRIFLUOROMETHYL)PHENYL)-3,5-PYRIDINEDICARBOXYLATE

Systematic Name

English

3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-1-(2-(4-MORPHOLINYL)ETHYL)-4-(2-(TRIFLUOROMETHYL)PHENYL)-, DIETHYL ESTER

Common Name

English

flordipine [INN]

Common Name

English

RHC-2906

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C333