1,7-DIMETHYLURIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H8N4O3
Molecular Weight	196.1634
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C(=O)NC2=C1C(=O)N(C)C(=O)N2

InChI

InChIKey=NOFNCLGCUJJPKU-UHFFFAOYSA-N

InChI=1S/C7H8N4O3/c1-10-3-4(8-6(10)13)9-7(14)11(2)5(3)12/h1-2H3,(H,8,13)(H,9,14)

HIDE SMILES / InChI

Molecular Formula	C7H8N4O3
Molecular Weight	196.1634
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Plant polyphenol curcumin significantly affects CYP1A2 and CYP2A6 activity in healthy, male Chinese volunteers.	2010-06	20484172
Simultaneous action of the flavonoid quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase and xanthine oxidase activity in healthy volunteers.	2009-08	19215233
CYP2A6 activity in a healthy Spanish population: effect of age, sex, smoking, and oral contraceptives.	2008-05	18715882
Growth hormone does not alter CYP2A6 activity in growth hormone-deficient children.	2008-01	17927692
In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios.	2007-02	17221922
Concordance between the deduced acetylation status generated by high-speed: real-time PCR based NAT2 genotyping of seven single nucleotide polymorphisms and human NAT2 phenotypes determined by a caffeine assay.	2007-02	17011540
Soluble neuroprotective antioxidant uric acid analogs ameliorate ischemic brain injury in mice.	2007	17999205
Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls.	2006-12	17089110
[Determination of the activity of cytochrome P-450 CYP2A6 by HPLC method with caffeine as metabolizing probe].	2006-03	16759004
Measurement of caffeine and five of the major metabolites in urine by high-performance liquid chromatography/tandem mass spectrometry.	2005-03	15685651
Separation, pre-concentration, and HPLC analysis of methylxanthines in urine samples.	2004-10	15537072
Catabolism of caffeine in plants and microorganisms.	2004-05-01	14977550
Cytochrome P450 1A2 (CYP1A2) activity, mammographic density, and oxidative stress: a cross-sectional study.	2004	15217501
Interaction of ibuprofen and probenecid with drug metabolizing enzyme phenotyping procedures using caffeine as the probe drug.	2003-02	12580991
Novel markers of susceptibility to carcinogens in diet: associations with colorectal cancer.	2002-12-27	12505289
A population phenotyping study of three drug-metabolizing enzymes in Kyushu, Japan, with use of the caffeine test.	2002-08	12189367
Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction.	2002-08	12189363
CYP2A6 activity determined by caffeine phenotyping: association with colorectal cancer risk.	2002-04	11927498
Urinary biomarkers for assessing dietary exposure to caffeine.	2001-12	11761118
Use of novel solid-phase extraction sorbent materials for high-performance liquid chromatography quantitation of caffeine metabolism products methylxanthines and methyluric acids in samples of biological origin.	2001-08-15	11499474
The effect of pregnancy on cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activities in humans.	2001-08	11503005
Extractionless method for the simultaneous high-performance liquid chromatographic determination of urinary caffeine metabolites for N-acetyltransferase 2, cytochrome P450 1A2 and xanthine oxidase activity assessment.	2001-05-05	11393735
Caffeine metabolism before and after liver transplantation.	2001-02	11270802
Caffeine metabolism in a group of 67 patients with primary biliary cirrhosis.	2001-01	11204934

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:39:49 GMT 2025` Edited by `admin` on `Mon Mar 31 19:39:49 GMT 2025`
Record UNII	Z633Z7KAJU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

URIC ACID, 1,7-DIMETHYL-

Preferred Name

English

1,7-DIMETHYLURIC ACID

Systematic Name

English

1H-PURINE-2,6,8(3H)-TRIONE, 7,9-DIHYDRO-1,7-DIMETHYL-

Systematic Name

English

7,9-DIHYDRO-1,7-DIMETHYL-1H-PURINE-2,6,8(3H)-TRIONE

Systematic Name

English

Code System Code Type Description

FDA UNII

Z633Z7KAJU