1,7-DIMETHYLURIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H8N4O3
Molecular Weight	196.1634
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C(=O)NC2=C1C(=O)N(C)C(=O)N2

InChI

InChIKey=NOFNCLGCUJJPKU-UHFFFAOYSA-N

InChI=1S/C7H8N4O3/c1-10-3-4(8-6(10)13)9-7(14)11(2)5(3)12/h1-2H3,(H,8,13)(H,9,14)

HIDE SMILES / InChI

Molecular Formula	C7H8N4O3
Molecular Weight	196.1634
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
The effect of pregnancy on cytochrome P4501A2, xanthine oxidase, and N-acetyltransferase activities in humans.	2001 Aug	11503005
Use of novel solid-phase extraction sorbent materials for high-performance liquid chromatography quantitation of caffeine metabolism products methylxanthines and methyluric acids in samples of biological origin.	2001 Aug 15	11499474
Urinary biomarkers for assessing dietary exposure to caffeine.	2001 Dec	11761118
Extractionless method for the simultaneous high-performance liquid chromatographic determination of urinary caffeine metabolites for N-acetyltransferase 2, cytochrome P450 1A2 and xanthine oxidase activity assessment.	2001 May 5	11393735
A population phenotyping study of three drug-metabolizing enzymes in Kyushu, Japan, with use of the caffeine test.	2002 Aug	12189367
Novel markers of susceptibility to carcinogens in diet: associations with colorectal cancer.	2002 Dec 27	12505289
Interaction of ibuprofen and probenecid with drug metabolizing enzyme phenotyping procedures using caffeine as the probe drug.	2003 Feb	12580991
Cytochrome P450 1A2 (CYP1A2) activity, mammographic density, and oxidative stress: a cross-sectional study.	2004	15217501
Catabolism of caffeine in plants and microorganisms.	2004 May 1	14977550
Separation, pre-concentration, and HPLC analysis of methylxanthines in urine samples.	2004 Oct	15537072
Measurement of caffeine and five of the major metabolites in urine by high-performance liquid chromatography/tandem mass spectrometry.	2005 Mar	15685651
Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls.	2006 Dec	17089110
[Determination of the activity of cytochrome P-450 CYP2A6 by HPLC method with caffeine as metabolizing probe].	2006 Mar	16759004
Soluble neuroprotective antioxidant uric acid analogs ameliorate ischemic brain injury in mice.	2007	17999205
In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios.	2007 Feb	17221922
Concordance between the deduced acetylation status generated by high-speed: real-time PCR based NAT2 genotyping of seven single nucleotide polymorphisms and human NAT2 phenotypes determined by a caffeine assay.	2007 Feb	17011540
Growth hormone does not alter CYP2A6 activity in growth hormone-deficient children.	2008 Jan	17927692
CYP2A6 activity in a healthy Spanish population: effect of age, sex, smoking, and oral contraceptives.	2008 May	18715882
Simultaneous action of the flavonoid quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase and xanthine oxidase activity in healthy volunteers.	2009 Aug	19215233
Plant polyphenol curcumin significantly affects CYP1A2 and CYP2A6 activity in healthy, male Chinese volunteers.	2010 Jun	20484172

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:14:47 GMT 2023` Edited by `admin` on `Fri Dec 15 19:14:47 GMT 2023`
Record UNII	Z633Z7KAJU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1,7-DIMETHYLURIC ACID

Systematic Name

English

1H-PURINE-2,6,8(3H)-TRIONE, 7,9-DIHYDRO-1,7-DIMETHYL-

Systematic Name

English

7,9-DIHYDRO-1,7-DIMETHYL-1H-PURINE-2,6,8(3H)-TRIONE

Systematic Name

English

URIC ACID, 1,7-DIMETHYL-

Common Name

English

Code System Code Type Description

FDA UNII

Z633Z7KAJU