ASFOTASE ALFA

Approval Year

Substance Class	Protein
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	Z633861EIM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ASFOTASE ALFA

Official Name

English

ALXN-1215

Code

English

ASFOTASE ALFA [USAN]

Common Name

English

Asfotase alfa [WHO-DD]

Common Name

English

TISSUE-NONSPECIFIC ALKALINE PHOSPHATASE- IGG1 FUSION PROTEIN

Common Name

English

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Classification Tree

Code System

Code

Positive

EU-Orphan Drug

EU/3/08/594

Established Pharmacologic Class

NDF-RT

N0000191865

Designated/Approved

FDA ORPHAN DRUG

266608

Enzymes

WHO-ATC

A16AB13

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Code System

Code

Type

Description

EVMPD

SUB168381

PRIMARY

DRUG CENTRAL

5049

PRIMARY

FDA UNII

Z633861EIM

PRIMARY

DRUG BANK

DB09105

PRIMARY

USAN

AB-112

PRIMARY

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Subunit 0

Subunit 1

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From	To
1_122	1_184
1_472	1_480
1_493	2_493
1_496	2_496
1_528	1_588

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Glycosylation Type

MAMMALIAN

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Glycosylation Link Type	Site
N	1_123
N	1_213
N	1_254
N	1_286
N	1_413

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Related Record

Type

Details


					G72T8FL60W

SPHINGOSINE 1-PHOSPHATE RECEPTOR 1

TARGET -> AGONIST


					N3W8UZM18I

ALKALINE PHOSPHATASE, TISSUE-NONSPECIFIC ISOZYME

TARGET->ENZYME REPLACEMENT

Amount:

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Related Record

Type

Details


					Z633861EIM

ASFOTASE ALFA

ACTIVE MOIETY

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Name	Property Type	Amount
Molecular Formula	CHEMICAL	ESTIMATED C7108H10954N1968O2206S56
MOL_WEIGHT:ESTIMATE(SDS-PAGE)	CHEMICAL	ESTIMATE 200000 Da (average)
Biological Half-life	PHARMACOKINETIC	5 days (average)