Esonadogene Imvoparvovec

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 19:56:02 UTC 2023` Edited by `admin` on `Sat Dec 16 19:56:02 UTC 2023`
Source Materials Class	ORGANISM
Source Materials Type	RECOMBINANT PROTEINS
Source Materials State	LIVE NON-REPLICATING GENETICALLY MODIFIED
Organism Family	Parvoviridae
Organism Genus	Dependoparvovirus
Organism Species	adeno-associated dependoparvovirus a
Infraspecific Type	RECOMBINANT VECTOR
Infraspecific Name	AAV2-CMV-MTS-ND4 ORF
Part	whole
Record UNII	Z57CL8M2AE
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Esonadogene Imvoparvovec

Official Name

English

recombinant, non-replicating adeno-associated virus serotype 2 (AAV2) vector encoding codon-optimised human NADH dehydrogenase subunit 4 (also known as NADH-ubiquinone oxidoreductase chain 4; MTND4, NADH4, ND4) preceded by a Kozak sequence and a mitochon

Common Name

English

esonadogene imvoparvovec [INN]

Common Name

English

DNA (recombinant replication-defective adeno-associated virus 2 vector NFS01 human cytomegalovirus enhancer plus human cytomegalovirus promoter plus Macacine herpesvirus 3 chimeric intron plus human heme A farnesyltransferase gene COX10 mitochondrial tar

Common Name

English

Code System Code Type Description

FDA UNII

Z57CL8M2AE

Created by admin on Sat Dec 16 19:56:02 UTC 2023 , Edited by admin on Sat Dec 16 19:56:02 UTC 2023

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NCI_THESAURUS

C199044

Created by admin on Sat Dec 16 19:56:02 UTC 2023 , Edited by admin on Sat Dec 16 19:56:02 UTC 2023

PRIMARY

INN

12424

Created by admin on Sat Dec 16 19:56:02 UTC 2023 , Edited by admin on Sat Dec 16 19:56:02 UTC 2023

PRIMARY

CAS

2678565-23-4

Created by admin on Sat Dec 16 19:56:02 UTC 2023 , Edited by admin on Sat Dec 16 19:56:02 UTC 2023

PRIMARY

Related Record Type Details


					H2YT7BG33E

NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4

EXPRESSED PROTEIN->VECTOR

Amount:

Related Record Type Details


					Z57CL8M2AE

Esonadogene Imvoparvovec

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
INSERTED GENE EXPRESSION VECTOR					Esonadogene imvoparvovec transgene insert	5EY75BA8K6