Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H13O4.Na |
| Molecular Weight | 196.1762 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].OC(=O)CCCCCCC([O-])=O
InChI
InChIKey=SLVJLFOSPGAWHC-UHFFFAOYSA-M
InChI=1S/C8H14O4.Na/c9-7(10)5-3-1-2-4-6-8(11)12;/h1-6H2,(H,9,10)(H,11,12);/q;+1/p-1
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C8H13O4 |
| Molecular Weight | 173.1864 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Suberic acid, also octanedioic acid, is a dicarboxylic acid, with formula C6H12(COOH)2. It is present in the urine of patients with fatty acid oxidation disorders. A metabolic breakdown product derived from oleic acid. Elevated levels of this unstaruated dicarboxylic acid are found in individuals with medium-chain acyl-CoA dehydrogenase deficiency (MCAD). Suberic acid is also found to be associated with carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency, which are also inborn errors of metabolism. Suberic Acid is used in the preparation of reduction-sensitive micelles affecting their cellular uptake. This has potential application in delivery of anticancer drugs. It is also used in the fluorescent detection of amidinium-carboxylate and amidinium formation.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Dicarboxylic aciduria: the response to fasting. | 1979 May 16 |
|
| Microbial transformation of bile acids. A unified scheme for bile acid degradation, and hydroxylation of bile acids. | 1982 |
|
| Prenatal diagnosis of glutaric aciduria type II by direct chemical analysis of dicarboxylic acids in amniotic fluid. | 1984 Jan |
|
| Inhibition of HIV-1 proteinase by non-peptide carboxylates. | 1991 Apr 15 |
|
| Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease. | 1991 Jan 2 |
|
| Physiology and pathophysiology of organic acids in cerebrospinal fluid. | 1993 |
|
| Bissulfosuccinimidyl esters of aliphatic dicarboxylic acids: a new class of 'affinity directed' beta beta crosslinkers of HbA. | 1994 |
|
| Age-related reference values for urinary organic acids in a healthy Turkish pediatric population. | 1994 Jun |
|
| Measurements of urinary adipic acid and suberic acid using high-performance liquid chromatography. | 1994 May 13 |
|
| A GC/MS/MS screening method for multiple organic acidemias from urine specimens. | 1999 May |
|
| Average structure of the composite crystal urea/octanedioic acid at room temperature within the superspace formalism. | 2001 Jun |
|
| Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens. | 2001 Mar |
|
| The first case of 4-hydroxybutyric aciduria in Japan. | 2001 Mar |
|
| Steryl and stanyl esters of fatty acids by solvent-free esterification and transesterification in vacuo using lipases from Rhizomucor miehei, Candida antarctica, and Carica papaya. | 2001 Nov |
|
| [Late-onset riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency (glutaric aciduria type II)]. | 2003 Dec |
|
| Neuromuscular blocking activity and therapeutic potential of mixed-tetrahydroisoquinolinium halofumarates and halosuccinates in rhesus monkeys. | 2003 Jun 5 |
|
| Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. | 2003 Oct |
|
| The first suberate lanthanum(III) complex without uncoordinated water. | 2004 Aug |
|
| Solvent-mediated folding of a doubly charged anion. | 2004 Jan 28 |
|
| Bulk versus interfacial aqueous solvation of dicarboxylate dianions. | 2004 Sep 22 |
|
| Disuccinimidyl suberate cross-linked hemoglobin as a novel red blood cell substitute. | 2005 Feb |
|
| Synthesis, Superoxide Dismutase Mimetic and Anticancer Activities of Metal Complexes of 2,2-Dimethylpentanedioic Acid(2dmepdaH(2)) and 3,3-Dimethylpentanedioic acid(3dmepdaH(2)): X-Ray Crystal Structures of [Cu(3dmepda)(bipy)](2). 6H(2)O and [Cu(2dmepda)(bipy)(EtOH)](2). 4EtOH (bipy = 2,2'Bipyridine). | 2006 |
|
| A dimeric cobalt(II)-suberate complex with 3-aminopyridine. | 2006 Nov |
|
| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 Nov |
|
| Host-guest adaptability within oxothiomolybdenum wheels: structures, studies in solution and DFT calculations. | 2007 Jul 28 |
|
| Steroidogenic activity of StAR requires contact with mitochondrial VDAC1 and phosphate carrier protein. | 2008 Apr 4 |
|
| Determination of insulin in innovative formulations by means of LC coupled to fluorescence detection. | 2008 Dec 15 |
|
| (Heptanedioato-κO,O')bis-(1,10-phenanthroline-κN,N')zinc(II) hexa-hydrate. | 2008 Mar 7 |
|
| Metabolomic profiling of dietary-induced insulin resistance in the high fat-fed C57BL/6J mouse. | 2008 Sep |
|
| Synthesis, Binding and Fluorescence Studies of Bis-2-amidopyrrole Receptors for Bis-carboxylate Anions. | 2009 |
|
| Radiation metabolomics. 3. Biomarker discovery in the urine of gamma-irradiated rats using a simplified metabolomics protocol of gas chromatography-mass spectrometry combined with random forests machine learning algorithm. | 2009 Aug |
|
| New 2-methylimidazole-dicarboxylic acid molecular crystals: crystal structure and proton conductivity. | 2009 Aug 26 |
|
| Diaphorobacter oryzae sp. nov., isolated from a thiosulfate-oxidizing enrichment culture. | 2009 Feb |
|
| 2,2'-Hexamethyl-enedi-1,3-benzothia-zole. | 2009 Jan 14 |
|
| Metabolic profiling of Parkinson's disease: evidence of biomarker from gene expression analysis and rapid neural network detection. | 2009 Jul 13 |
|
| In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin. | 2009 Mar 27 |
|
| Direct Repeat 6 from human herpesvirus-6B encodes a nuclear protein that forms a complex with the viral DNA processivity factor p41. | 2009 Oct 15 |
|
| 2-Amino-6-methyl-1,3-benzothia-zole-octa-nedioic acid (2/1). | 2009 Oct 23 |
|
| Evidence for alternative quaternary structure in a bacterial Type III secretion system chaperone. | 2010 Jul 15 |
|
| Cow's milk allergy is associated with changes in urinary organic acid concentrations. | 2010 Mar |
|
| Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509). | 2010 Nov 30 |
|
| Enhanced immunogenicity of stabilized trimeric soluble influenza hemagglutinin. | 2010 Sep 1 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:11:32 GMT 2023
by
admin
on
Sat Dec 16 11:11:32 GMT 2023
|
| Record UNII |
Z4MK0NP0F0
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
23705259
Created by
admin on Sat Dec 16 11:11:32 GMT 2023 , Edited by admin on Sat Dec 16 11:11:32 GMT 2023
|
PRIMARY | |||
|
59481-64-0
Created by
admin on Sat Dec 16 11:11:32 GMT 2023 , Edited by admin on Sat Dec 16 11:11:32 GMT 2023
|
NON-SPECIFIC STOICHIOMETRY | |||
|
Z4MK0NP0F0
Created by
admin on Sat Dec 16 11:11:32 GMT 2023 , Edited by admin on Sat Dec 16 11:11:32 GMT 2023
|
PRIMARY | |||
|
27796-70-9
Created by
admin on Sat Dec 16 11:11:32 GMT 2023 , Edited by admin on Sat Dec 16 11:11:32 GMT 2023
|
PRIMARY |