Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C3H5NO2 |
| Molecular Weight | 87.0773 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C1NCCO1
InChI
InChIKey=IZXIZTKNFFYFOF-UHFFFAOYSA-N
InChI=1S/C3H5NO2/c5-3-4-1-2-6-3/h1-2H2,(H,4,5)
| Molecular Formula | C3H5NO2 |
| Molecular Weight | 87.0773 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Synthesis and biological evaluation of five-membered heterocycles fused to cyclopenta[c]thiophene as new antitumor agents. | 2003-04-03 |
|
| Chiral-auxiliary-controlled diastereoselectivity in the epoxidation of enecarbamates with DMD and mCPBA. | 2003-03-20 |
|
| Monoamine oxidases: to inhibit or not to inhibit. | 2003-03 |
|
| Comparison of nitration and oxidation of tyrosine in advanced human carotid plaque proteins. | 2003-02-15 |
|
| Asymmetric epoxidation catalyzed by N-aryl-substituted oxazolidinone-containing ketones: further evidence for electronic effects. | 2003-02-06 |
|
| Clinical experience with linezolid for the treatment of nocardia infection. | 2003-02-01 |
|
| Multicentre evaluation of the in vitro activity of linezolid in the Western Pacific. | 2003-02 |
|
| Concise stereocontrolled routes to fumagillol, fumagillin, and TNP-470. | 2003-02 |
|
| Linezolid: the first oxazolidinone antimicrobial. | 2003-01-21 |
|
| Identification of phenylisoxazolines as novel and viable antibacterial agents active against Gram-positive pathogens. | 2003-01-16 |
|
| Relationship between stereochemistry and the beta3-adrenoceptor agonistic activity of 4'-hydroxynorephedrine derivative as an agent for treatment of frequent urination and urinary incontinence. | 2003-01-02 |
|
| Synthesis and antibacterial activity of 5-substituted oxazolidinones. | 2003-01-02 |
|
| Linezolid: implications for neurosurgical infections. | 2003-01 |
|
| [Role of linezolid in antimicrobial therapy]. | 2003-01 |
|
| Linezolid: an oxazolidinone antimicrobial agent. | 2002-12-15 |
|
| Multicentre assessment of linezolid antimicrobial activity and spectrum in Europe: report from the Zyvox antimicrobial potency study (ZAPS-Europe). | 2002-12 |
|
| Clinical failures of linezolid and implications for the clinical microbiology laboratory. | 2002-12 |
|
| Epoxyalcohol route to hydroxyethylene dipeptide isosteres. Stereodivergent synthesis of the diamino alcohol core of ritonavir and its C-2 epimer. | 2002-11-29 |
|
| A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration. | 2002-11-04 |
|
| Linezolid-resistant enterococci: report of the first isolates in the United Kingdom. | 2002-11 |
|
| Virulence factor expression by Gram-positive cocci exposed to subinhibitory concentrations of linezolid. | 2002-11 |
|
| Design, synthesis, and evaluation of 4-(4'-aminobenzyl)-2-oxazolidinones as novel inhibitors of the cytochrome P-450 enzyme aromatase. | 2002-10 |
|
| Emerging linezolid-resistant Enterococcus faecalis and Enterococcus faecium isolated from two Austrian patients in the same intensive care unit. | 2002-10 |
|
| The protein synthesis inhibitors, oxazolidinones and chloramphenicol, cause extensive translational inaccuracy in vivo. | 2002-09-13 |
|
| First characterization of a cluster of VanA-type glycopeptide-resistant Enterococcus faecium, Colombia. | 2002-09 |
|
| Synthesis of conformationally constrained analogues of linezolid: structure-activity relationship (SAR) studies on selected novel tricyclic oxazolidinones. | 2002-08-29 |
|
| Regio- and stereoselective synthesis of (E)-alkene trans-Xaa-Pro dipeptide mimetics utilizing organocopper-mediated anti-S(N)2' reactions. | 2002-08-23 |
|
| Palladium-catalyzed aminoallylation of activated olefins with allylic halides and phthalimide. | 2002-08-23 |
|
| Synthesis of chiral pilocarpine analogues via a C-8 ketone intermediate. | 2002-08-23 |
|
| The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class. | 2002-08-19 |
|
| Efficient asymmetric synthesis of (S)-2-ethylphenylpropanoic acid derivative, a selective agonist for human peroxisome proliferator-activated receptor alpha. | 2002-08-19 |
|
| [Prospects for development of new antituberculous drugs]. | 2002-08 |
|
| Treatment of Staphylococcus epidermidis ventriculo-peritoneal shunt infection with linezolid. | 2002-08 |
|
| In vitro activity of AZD2563, a novel oxazolidinone, against European Gram-positive cocci. | 2002-08 |
|
| Highly diastereoselective dioxetane formation in the photooxygenation of enecarbamates with an oxazolidinone chiral auxiliary: steric control in the [2 + 2] cycloaddition of singlet oxygen through conformational alignment. | 2002-07-31 |
|
| Synthesis of sphingomyelin carbon analogues as sphingomyelinase inhibitors. | 2002-07-12 |
|
| Anti-anaerobic activity of AZD2563, a new oxazolidinone, compared with eight other agents. | 2002-07 |
|
| Antipneumococcal activity of AZD2563, a new oxazolidinone, compared with nine other agents. | 2002-07 |
|
| In vitro activity of a novel oxazolidinone, AZD2563, against randomly selected and multiresistant Gram-positive cocci. | 2002-07 |
|
| A new approach to (-)-swainsonine by ruthenium-catalyzed ring rearrangement. | 2002-06-14 |
|
| Novel oxazolidinone based compounds as inhibitors of aromatase and the use of the substrate-heme complex approach in the rationalisation of these compounds. | 2002-06-07 |
|
| AZD-2563 AstraZeneca. | 2002-06 |
|
| Comparative activity of linezolid against staphylococci and enterococci isolated in Italy. | 2002-06 |
|
| AZD2563, a new oxazolidinone: bactericidal activity and synergy studies combined with gentamicin or vancomycin against staphylococci and streptococcal strains. | 2002-05 |
|
| A multicenter evaluation of linezolid antimicrobial activity in North America. | 2002-05 |
|
| Spectrum and potency evaluation of a new oxazolidinone, linezolid: report from the SENTRY Antimicrobial Surveillance Program, 1998-2000. | 2002-05 |
|
| Novel agents for resistant Gram-positive infections--a review. | 2002-03 |
|
| [Linezolid--new antibacterial agent of the oxazolidinone group: its importance in the control of spreading and treatment of the multidrug resistance gram-positive infections]. | 2002 |
|
| The discovery of linezolid, the first oxazolidinone antibacterial agent. | 2001-08 |
|
| Clinical trial results with linezolid, an oxazolidinone, in the treatment of soft tissue and postoperative gram-positive infections. | 2001 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:59:08 GMT 2025
by
admin
on
Mon Mar 31 18:59:08 GMT 2025
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| Record UNII |
Z4D49W92PP
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| Record Status |
Validated (UNII)
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| Record Version |
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38240
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Oxazolidinone
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1237
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35382
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Z4D49W92PP
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51667-26-6
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497-25-6
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73949
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DTXSID2074326
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207-840-9
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