RIVASTIGMINE, (R)-

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C14H22N2O2
Molecular Weight	250.3367
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(C)C(=O)OC1=CC=CC(=C1)[C@@H](C)N(C)C

InChI

InChIKey=XSVMFMHYUFZWBK-LLVKDONJSA-N

InChI=1S/C14H22N2O2/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4/h7-11H,6H2,1-5H3/t11-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C14H22N2O2
Molecular Weight	250.3367
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: Komsta, L. et al. (2013) 'Thin Layer Chromatography in Drug Analysis', p.451 Retrieved from https://books.google.ru/books?id=LSEtAgAAQBAJ | https://www.ncbi.nlm.nih.gov/pubmed/16013594

Rivastigmine, (R)- is an impurity of a brain selective acetylcholinesterase inhibitor Rivastigmine. R-Rivastigmine enantiomer is pharmacologically less potent than S-enantiomer, which is used for the treatment of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Enantioselective separation of rivastigmine by capillary electrophoresis with cyclodextrines.	2005 Jul 15	16013594
A validated chiral liquid chromatographic method for the enantiomeric separation of Rivastigmine hydrogen tartarate, a cholinesterase inhibitor.	2005 Jun 15	15925225

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:22:16 GMT 2023` Edited by `admin` on `Sat Dec 16 08:22:16 GMT 2023`
Record UNII	Z25UDQ15MV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RIVASTIGMINE, (R)-

Common Name

English

RIVASTIGMINE TARTRATE R-ISOMER [USP-RS]

Common Name

English

(R)-RIVASTIGMINE

Common Name

English

RIVASTIGMINE TARTRATE R-ISOMER

Common Name

English

CARBAMIC ACID, N-ETHYL-N-METHYL-, 3-((1R)-1-(DIMETHYLAMINO)ETHYL)PHENYL ESTER

Systematic Name

English

RIVASTIGMINE IMPURITY D [EP IMPURITY]

Common Name

English

SDZ-212712

Code

English

RIVASTIGMINE HYDROGEN TARTRATE IMPURITY D [EP IMPURITY]

Common Name

English

Code System Code Type Description

RS_ITEM_NUM

1604847