Details
Stereochemistry | ACHIRAL |
Molecular Formula | C14H16BrNO2.ClH |
Molecular Weight | 346.647 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.COC1=CC2=C(OC(=C2)C3CCNCC3)C(Br)=C1
InChI
InChIKey=PUYKEOGYPYITCW-UHFFFAOYSA-N
InChI=1S/C14H16BrNO2.ClH/c1-17-11-6-10-7-13(9-2-4-16-5-3-9)18-14(10)12(15)8-11;/h6-9,16H,2-5H2,1H3;1H
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C14H16BrNO2 |
Molecular Weight | 310.186 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Brofaromine (proposed brand name Consonar) is a reversible inhibitor of monoamine oxidase A (RIMA) developed by Ciba-Geigy for depression and anxiety disorders treatment. Brofaromine induces short, reversible and selective inhibition of brain MAO of type A in a dose-dependent manner in all brain regions. The largest decrease being found respectively in hippocampus, striatum and prefrontal cortex, regions having a rich monoaminergic innervation. Brofaromine also acts as a serotonin reuptake inhibitor, and its dual pharmacologic effects offered promise in the treatment of a wide spectrum of depressed patients while producing less severe anticholinergic side effects in comparison with older standard drugs like the tricyclic antidepressants. The compound was primarily researched in the treatment of depression and anxiety but its development was dropped before it was brought to market.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
A double-blind comparative study of brofaromine and fluvoxamine in outpatients with panic disorder. | 1996 Aug |
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Antidepressants versus placebo for people with bulimia nervosa. | 2001 |
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Treatment of social phobia with antidepressants. | 2001 |
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Predictors of treatment response in patients with posttraumatic stress disorder. | 2001 Feb |
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Antidepressants in social anxiety disorder. | 2001 Sep |
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Pirlindole and dehydropirlindole protect rat cultured neuronal cells against oxidative stress-induced cell death through a mechanism unrelated to MAO-A inhibition. | 2002 Feb |
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Pharmacotherapy of social anxiety disorder. | 2002 Jan 1 |
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Psychopharmacology of anxiety disorders. | 2002 Sep |
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Antidepressants versus placebo for people with bulimia nervosa. | 2003 |
|
Pharmacotherapy of social phobia. | 2003 |
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Pharmacological treatment of social anxiety disorder: a meta-analysis. | 2003 |
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Pre- and post-treatment with pirlindole and dehydropirlindole protects cultured brain cells against nitric oxide-induced death. | 2003 Apr 11 |
|
SL25.1131 [3(S),3a(S)-3-methoxymethyl-7-[4,4,4-trifluorobutoxy]-3,3a,4,5-tetrahydro-1,3-oxazolo[3,4-a]quinolin-1-one], a new, reversible, and mixed inhibitor of monoamine oxidase-A and monoamine oxidase-B: biochemical and behavioral profile. | 2004 Sep |
|
Fluvoxamine in the treatment of anxiety disorders. | 2005 Dec |
|
Design, synthesis, and biological activities of pyrrolylethanoneamine derivatives, a novel class of monoamine oxidases inhibitors. | 2005 Jun 30 |
|
Transdermal selegiline for the treatment of major depressive disorder. | 2007 |
|
Post-traumatic stress disorder. | 2007 Aug 1 |
|
Management of anorexia and bulimia nervosa: An evidence-based review. | 2010 Apr |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:47:43 GMT 2023
by
admin
on
Fri Dec 15 15:47:43 GMT 2023
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Record UNII |
Z1JJCCZX3P
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Record Status |
Validated (UNII)
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Record Version |
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DTXSID10979854
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44570
Created by
admin on Fri Dec 15 15:47:43 GMT 2023 , Edited by admin on Fri Dec 15 15:47:43 GMT 2023
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Z1JJCCZX3P
Created by
admin on Fri Dec 15 15:47:43 GMT 2023 , Edited by admin on Fri Dec 15 15:47:43 GMT 2023
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PRIMARY |
Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |