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Details

Stereochemistry ACHIRAL
Molecular Formula C14H16BrNO2.ClH
Molecular Weight 346.647
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BROFAROMINE HYDROCHLORIDE

SMILES

Cl.COC1=CC2=C(OC(=C2)C3CCNCC3)C(Br)=C1

InChI

InChIKey=PUYKEOGYPYITCW-UHFFFAOYSA-N
InChI=1S/C14H16BrNO2.ClH/c1-17-11-6-10-7-13(9-2-4-16-5-3-9)18-14(10)12(15)8-11;/h6-9,16H,2-5H2,1H3;1H

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C14H16BrNO2
Molecular Weight 310.186
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Brofaromine (proposed brand name Consonar) is a reversible inhibitor of monoamine oxidase A (RIMA) developed by Ciba-Geigy for depression and anxiety disorders treatment. Brofaromine induces short, reversible and selective inhibition of brain MAO of type A in a dose-dependent manner in all brain regions. The largest decrease being found respectively in hippocampus, striatum and prefrontal cortex, regions having a rich monoaminergic innervation. Brofaromine also acts as a serotonin reuptake inhibitor, and its dual pharmacologic effects offered promise in the treatment of a wide spectrum of depressed patients while producing less severe anticholinergic side effects in comparison with older standard drugs like the tricyclic antidepressants. The compound was primarily researched in the treatment of depression and anxiety but its development was dropped before it was brought to market.

Approval Year

PubMed

PubMed

TitleDatePubMed
A double-blind comparative study of brofaromine and fluvoxamine in outpatients with panic disorder.
1996 Aug
Antidepressants versus placebo for people with bulimia nervosa.
2001
Treatment of social phobia with antidepressants.
2001
Predictors of treatment response in patients with posttraumatic stress disorder.
2001 Feb
Antidepressants in social anxiety disorder.
2001 Sep
Pirlindole and dehydropirlindole protect rat cultured neuronal cells against oxidative stress-induced cell death through a mechanism unrelated to MAO-A inhibition.
2002 Feb
Pharmacotherapy of social anxiety disorder.
2002 Jan 1
Psychopharmacology of anxiety disorders.
2002 Sep
Antidepressants versus placebo for people with bulimia nervosa.
2003
Pharmacotherapy of social phobia.
2003
Pharmacological treatment of social anxiety disorder: a meta-analysis.
2003
Pre- and post-treatment with pirlindole and dehydropirlindole protects cultured brain cells against nitric oxide-induced death.
2003 Apr 11
SL25.1131 [3(S),3a(S)-3-methoxymethyl-7-[4,4,4-trifluorobutoxy]-3,3a,4,5-tetrahydro-1,3-oxazolo[3,4-a]quinolin-1-one], a new, reversible, and mixed inhibitor of monoamine oxidase-A and monoamine oxidase-B: biochemical and behavioral profile.
2004 Sep
Fluvoxamine in the treatment of anxiety disorders.
2005 Dec
Design, synthesis, and biological activities of pyrrolylethanoneamine derivatives, a novel class of monoamine oxidases inhibitors.
2005 Jun 30
Transdermal selegiline for the treatment of major depressive disorder.
2007
Post-traumatic stress disorder.
2007 Aug 1
Management of anorexia and bulimia nervosa: An evidence-based review.
2010 Apr
Patents

Patents

Substance Class Chemical
Created
by admin
on Fri Dec 15 15:47:43 GMT 2023
Edited
by admin
on Fri Dec 15 15:47:43 GMT 2023
Record UNII
Z1JJCCZX3P
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BROFAROMINE HYDROCHLORIDE
Common Name English
CGP-11305A
Code English
4-(7-BROMO-5-METHOXY-2-BENZOFURANYL)PIPERIDINE HYDROCHLORIDE
Systematic Name English
Code System Code Type Description
CAS
63638-90-4
Created by admin on Fri Dec 15 15:47:43 GMT 2023 , Edited by admin on Fri Dec 15 15:47:43 GMT 2023
PRIMARY
EPA CompTox
DTXSID10979854
Created by admin on Fri Dec 15 15:47:43 GMT 2023 , Edited by admin on Fri Dec 15 15:47:43 GMT 2023
PRIMARY
PUBCHEM
44570
Created by admin on Fri Dec 15 15:47:43 GMT 2023 , Edited by admin on Fri Dec 15 15:47:43 GMT 2023
PRIMARY
FDA UNII
Z1JJCCZX3P
Created by admin on Fri Dec 15 15:47:43 GMT 2023 , Edited by admin on Fri Dec 15 15:47:43 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE