Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H30N2O2.2ClH |
| Molecular Weight | 439.418 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.CCOC(=O)C1(CCN(CCCNC2=CC=CC=C2)CC1)C3=CC=CC=C3
InChI
InChIKey=NNUYKVKCPSVJRZ-UHFFFAOYSA-N
InChI=1S/C23H30N2O2.2ClH/c1-2-27-22(26)23(20-10-5-3-6-11-20)14-18-25(19-15-23)17-9-16-24-21-12-7-4-8-13-21;;/h3-8,10-13,24H,2,9,14-19H2,1H3;2*1H
| Molecular Formula | C23H30N2O2 |
| Molecular Weight | 366.4965 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Piminodine is an analog of pethidine. It was used in medicine for obstetric analgesia and in dental procedures briefly during the 1960s and 1970s, but has largely fallen out of clinical use. Piminodine produces analgesia, sedation and euphoria and has typical side effects associated with opioids, including potentially serious respiratory depression, which can be life-threatening. Piminodine was more potent than desipramine and protriptyline under similar conditions. Compared to meperidine, piminodine is more potent and gives smoother duration. Piminodine can be addictive. Piminodine is currently a Schedule II controlled substance in the United States.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The analgesic potency of piminodine (alvodine). | 1960 Aug |
|
| A comparison of the pharmacology of two potent analgesic agents, piminodine (Win 14,098-2) and Win 13,797, with morphine and meperidine. | 1961 May |
|
| The intravenous use of a new analgesic agent, piminodine in office urologic operative procedures. | 1962 Jul-Aug |
|
| Intravenous Alvodine. A clinical evalution. | 1963 May-Jun |
|
| ANALGESIA IN MYOCARDIAL INFARCTION: DOUBLE-BLIND COMPARISON OF PIMINODINE AND MORPHINE. | 1965 May |
|
| The effect of narcotic analgesics on the uptake of 5-hydroxytryptamine and (-)-metaraminol by blood platelets. | 1973 Apr |
|
| [New anti-curare and analeptic drug, Pimadin, and its use in anesthesia]. | 1973 Jul-Aug |
|
| Radioimmunoassay for anileridine, meperidine and other N-substituted phenylpiperidine carboxylic acid esters. | 1975 Oct |
|
| Effect of narcotic analgesics on the striatal homovanillic acid content in mice; relation to antinociceptive effect. | 1976 Feb |
|
| Investigation of narcotics and antitussives using drug discrimination techniques. | 1979 Nov |
|
| Electronic-topological study of the structure-activity relationships in a series of piperidine morphinomimetics. | 2002 Aug |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:11:02 GMT 2023
by
admin
on
Sat Dec 16 11:11:02 GMT 2023
|
| Record UNII |
Z14O2MUP76
|
| Record Status |
Validated (UNII)
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| Record Version |
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113862-30-9
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m1226
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admin on Sat Dec 16 11:11:02 GMT 2023 , Edited by admin on Sat Dec 16 11:11:02 GMT 2023
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PRIMARY | Merck Index | ||
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Z14O2MUP76
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admin on Sat Dec 16 11:11:02 GMT 2023 , Edited by admin on Sat Dec 16 11:11:02 GMT 2023
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72941654
Created by
admin on Sat Dec 16 11:11:02 GMT 2023 , Edited by admin on Sat Dec 16 11:11:02 GMT 2023
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| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
