U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 01:33:45 GMT 2025
Edited
by admin
on Wed Apr 02 01:33:45 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
Z0A08C63DF
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
INCAGN02385
Preferred Name English
Tuparstobart
USAN   INN  
Official Name English
gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV1-46*02 (80.4%)-(IGHD) -IGHJ4*01 (100%), CDR-IMGT[8.8.14] (26-33.51-58.97-110)) (1-121)-Homo sapiens IGHG1*03, G1m3, nG1m1, G1v29 CH2 A84.4 (CH1 R120 (218) (122-219), hinge 1-15 (220-234), CH2 N8
Common Name English
AGEN-2385
Code English
INCAGN-02385
Code English
TUPARSTOBART [USAN]
Common Name English
immunoglobulin G1-kappa,anti-[Homo sapiens LAG3 (lymphocyte activating 3, lymphocyte-activation 3, CD223)], humanized monoclonal antibody
Common Name English
Immunoglobulin G1 [301-alanine,de-C-terminal-lysine], anti-(human lymphocyte activation gene-3 protein) (human-Mus musculus monoclonal INCAGN02385 ?1-chain), disulfide with human-Mus musculus monoclonal INCAGN02385 ?-chain, dimer
Common Name English
AGEN2385
Code English
INCAGN 02385 [WHO-DD]
Common Name English
ANTI-LAG-3 MONOCLONAL ANTIBODY INCAGN02385
Common Name English
tuparstobart [INN]
Common Name English
Code System Code Type Description
USAN
KL-190
Created by admin on Wed Apr 02 01:33:45 GMT 2025 , Edited by admin on Wed Apr 02 01:33:45 GMT 2025
PRIMARY
FDA UNII
Z0A08C63DF
Created by admin on Wed Apr 02 01:33:45 GMT 2025 , Edited by admin on Wed Apr 02 01:33:45 GMT 2025
PRIMARY
NCI_THESAURUS
C157127
Created by admin on Wed Apr 02 01:33:45 GMT 2025 , Edited by admin on Wed Apr 02 01:33:45 GMT 2025
PRIMARY NCIT
INN
12389
Created by admin on Wed Apr 02 01:33:45 GMT 2025 , Edited by admin on Wed Apr 02 01:33:45 GMT 2025
PRIMARY
CAS
2649466-03-3
Created by admin on Wed Apr 02 01:33:45 GMT 2025 , Edited by admin on Wed Apr 02 01:33:45 GMT 2025
PRIMARY
SMS_ID
300000041670
Created by admin on Wed Apr 02 01:33:45 GMT 2025 , Edited by admin on Wed Apr 02 01:33:45 GMT 2025
PRIMARY
From To
1_22 1_96
2_22 2_96
2_148 2_204
2_224 4_215
2_265 2_325
1_148 1_204
2_371 2_429
3_23 3_89
3_135 3_195
4_23 4_89
4_135 4_195
1_224 3_215
1_230 2_230
1_233 2_233
1_265 1_325
1_371 1_429
Related Record Type Details
Tuparstobart
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_1] [2_1] N-TERMINUS PIDOLIC ACID SZB83O1W42
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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