U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Sr
Molecular Weight 87.62
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of STRONTIUM

SMILES

[Sr]

InChI

InChIKey=KJNGJIPPQOFCSK-UHFFFAOYSA-N
InChI=1S/Sr.2H

HIDE SMILES / InChI

Molecular Formula Sr
Molecular Weight 87.62
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Strontium is a soft, silver-yellow, alkaline-earth metal, existing either in the elemental state or as the divalent ion. Strontium occurs naturally in the earth's mantle as a mixture of four stable isotopes, i.e. Sr-84, Sr-86, Sr-87, and Sr-88. Of these, Sr-88 is the most prevalent form, comprising about 83% of natural strontium. Natural stable strontium is abundant in the environment and can be found in all plant species. Consuming 75% of production, the primary use for strontium is in glass for color television cathode ray tubes, where it prevents X-ray emission. Acantharea, a relatively large group of marine radiolarian protozoa, produce intricate mineral skeletons composed of strontium sulfate. In biological systems, calcium is substituted in a small extent by strontium. In the human body, most of the absorbed strontium is deposited in the bones. The ratio of strontium to calcium in human bones is between 1:1000 and 1:2000, roughly in the same range as in the blood serum. The human body absorbs strontium as if it were its lighter congener calcium. Because the elements are chemically very similar, stable strontium isotopes do not pose a significant health threat. The average human has an intake of about two milligrams of strontium a day.

Approval Year

PubMed

PubMed

TitleDatePubMed
Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity.
2001 Apr 27
The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel.
2001 Feb 16
The role of endogenous human Trp4 in regulating carbachol-induced calcium oscillations in HEK-293 cells.
2002 Apr 19
Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products.
2002 May 15
Elevated levels of ferrimagnetic metals in foodchains supporting the Guam cluster of neurodegeneration: do metal nucleated crystal contaminants [corrected] evoke magnetic fields that initiate the progressive pathogenesis of neurodegeneration?
2004
A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium.
2004 May
Osteoprecursor cell response to strontium-containing hydroxyapatite ceramics.
2006 Dec 15
Structural studies of human alkaline phosphatase in complex with strontium: implication for its secondary effect in bones.
2006 Jul
Role of the outer beta-sheet in divalent cation modulation of alpha7 nicotinic receptors.
2006 Jul
Characterization and distribution of the selected metals in the scalp hair of cancer patients in comparison with normal donors.
2007 Sep
Analysis of 35 inorganic elements in teeth in relation to caries formation.
2009 Summer
Heavy metal cations permeate the TRPV6 epithelial cation channel.
2011 Jan
Strontium in the environment: Review about reactions of plants towards stable and radioactive strontium isotopes.
2019 Feb 25
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:53:42 GMT 2023
Edited
by admin
on Fri Dec 15 18:53:42 GMT 2023
Record UNII
YZS2RPE8LE
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
STRONTIUM
MI   WHO-DD  
Systematic Name English
STRONTIUM, ELEMENTAL
HSDB  
Common Name English
STRONTIUM, ELEMENTAL [HSDB]
Common Name English
SR
Common Name English
STRONTIUM [MI]
Common Name English
Strontium [WHO-DD]
Common Name English
Classification Tree Code System Code
DSLD 144 (Number of products:114)
Created by admin on Fri Dec 15 18:53:42 GMT 2023 , Edited by admin on Fri Dec 15 18:53:42 GMT 2023
NCI_THESAURUS C637
Created by admin on Fri Dec 15 18:53:42 GMT 2023 , Edited by admin on Fri Dec 15 18:53:42 GMT 2023
Code System Code Type Description
WIKIPEDIA
Strontium
Created by admin on Fri Dec 15 18:53:42 GMT 2023 , Edited by admin on Fri Dec 15 18:53:42 GMT 2023
PRIMARY
EPA CompTox
DTXSID3024312
Created by admin on Fri Dec 15 18:53:42 GMT 2023 , Edited by admin on Fri Dec 15 18:53:42 GMT 2023
PRIMARY
CHEBI
35104
Created by admin on Fri Dec 15 18:53:42 GMT 2023 , Edited by admin on Fri Dec 15 18:53:42 GMT 2023
PRIMARY
NCI_THESAURUS
C846
Created by admin on Fri Dec 15 18:53:42 GMT 2023 , Edited by admin on Fri Dec 15 18:53:42 GMT 2023
PRIMARY
PUBCHEM
5359327
Created by admin on Fri Dec 15 18:53:42 GMT 2023 , Edited by admin on Fri Dec 15 18:53:42 GMT 2023
PRIMARY
MERCK INDEX
m10235
Created by admin on Fri Dec 15 18:53:42 GMT 2023 , Edited by admin on Fri Dec 15 18:53:42 GMT 2023
PRIMARY Merck Index
DAILYMED
YZS2RPE8LE
Created by admin on Fri Dec 15 18:53:42 GMT 2023 , Edited by admin on Fri Dec 15 18:53:42 GMT 2023
PRIMARY
CAS
7440-24-6
Created by admin on Fri Dec 15 18:53:42 GMT 2023 , Edited by admin on Fri Dec 15 18:53:42 GMT 2023
PRIMARY
FDA UNII
YZS2RPE8LE
Created by admin on Fri Dec 15 18:53:42 GMT 2023 , Edited by admin on Fri Dec 15 18:53:42 GMT 2023
PRIMARY
RXCUI
10122
Created by admin on Fri Dec 15 18:53:42 GMT 2023 , Edited by admin on Fri Dec 15 18:53:42 GMT 2023
PRIMARY RxNorm
MESH
D013324
Created by admin on Fri Dec 15 18:53:42 GMT 2023 , Edited by admin on Fri Dec 15 18:53:42 GMT 2023
PRIMARY
EVMPD
SUB22920
Created by admin on Fri Dec 15 18:53:42 GMT 2023 , Edited by admin on Fri Dec 15 18:53:42 GMT 2023
PRIMARY
CHEBI
33324
Created by admin on Fri Dec 15 18:53:42 GMT 2023 , Edited by admin on Fri Dec 15 18:53:42 GMT 2023
PRIMARY
SMS_ID
100000086900
Created by admin on Fri Dec 15 18:53:42 GMT 2023 , Edited by admin on Fri Dec 15 18:53:42 GMT 2023
PRIMARY
HSDB
2545
Created by admin on Fri Dec 15 18:53:42 GMT 2023 , Edited by admin on Fri Dec 15 18:53:42 GMT 2023
PRIMARY
ECHA (EC/EINECS)
231-133-4
Created by admin on Fri Dec 15 18:53:42 GMT 2023 , Edited by admin on Fri Dec 15 18:53:42 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY