Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H20N2.2BrH |
| Molecular Weight | 402.167 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Br.Br.C(CNCC1=CC=CC=C1)NCC2=CC=CC=C2
InChI
InChIKey=GAVSNOAVQTWVCO-UHFFFAOYSA-N
InChI=1S/C16H20N2.2BrH/c1-3-7-15(8-4-1)13-17-11-12-18-14-16-9-5-2-6-10-16;;/h1-10,17-18H,11-14H2;2*1H
| Molecular Formula | BrH |
| Molecular Weight | 80.912 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C16H20N2 |
| Molecular Weight | 240.3434 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.drugs.com/dosage/penicillin-g-benzathine.html | https://www.google.com/patents/WO2013184202A1
Curator's Comment: description was created based on several sources, including
https://www.drugs.com/dosage/penicillin-g-benzathine.html | https://www.google.com/patents/WO2013184202A1
Benzathine is a diamine used as a component in some medications including benzathine phenoxymethylpenicillin and benzathine benzylpenicillin. Benzathine stabilises penicillin and prolongs its sojourn when injected into tissues. Benzathine have some hepatitis C virus inhibitorion activity in in vitro assay
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Medicine hypersensitivity--case report]. | 2004 Apr |
|
| Western blotting as the confirmatory test for syphilis in a patient with systemic lupus erythematosus. | 2004 Apr |
|
| Investigation of DNA damage in lymphocytes exposed to benzathine penicillin G. | 2004 Aug |
|
| Syphilis surveillance in France, 2000-2003. | 2004 Dec |
|
| Macrolide resistance in Treponema pallidum in the United States and Ireland. | 2004 Jul 8 |
|
| Syphilis control--a continuing challenge. | 2004 Jul 8 |
|
| Maternal syphilis: pathophysiology and treatment. | 2004 Jun |
|
| Benzathine penicillin formulations. | 2004 Jun |
|
| Relapse of secondary syphilis after benzathine penicillin G: molecular analysis. | 2004 Mar |
|
| Treatment of maternal syphilis in rural South Africa: effect of multiple doses of benzathine penicillin on pregnancy loss. | 2004 Nov |
|
| [Current syphilis therapies and serological control. Commentary on the article by M. Hartmann in Hautarzt, Volume 2 (2004)]. | 2004 Nov |
|
| [Sydenham's chorea. A clinical analysis of 55 patients with a prolonged follow-up]. | 2004 Nov 1-15 |
|
| [Syphilis with HIV coinfection]. | 2004 Oct |
|
| Syphilis in the HIV-infected patient: an update on epidemiology, diagnosis, and management. | 2004 Sep |
|
| Pustulocrustaceous secondary syphilis. | 2005 |
|
| Assessment of a register-based rheumatic heart disease secondary prevention program in an Australian Aboriginal community. | 2005 Dec |
|
| Colchicine and benzathine penicillin in the treatment of Behçet disease: a case comparative study. | 2005 Dec 1 |
|
| Case records of the Massachusetts General Hospital. Case 39-2005. A 63-year-old woman with a positive serologic test for syphilis and persistent eosinophilia. | 2005 Dec 22 |
|
| [A painful swelling of the tongue]. | 2005 Feb |
|
| Evaluation of syphilis in patients with HIV infection in Nigeria. | 2005 Jan |
|
| Effectiveness of syphilis treatment using azithromycin and/or benzathine penicillin in Rakai, Uganda. | 2005 Jan |
|
| Ionic liquids as advantageous solvents for headspace gas chromatography of compounds with low vapor pressure. | 2005 Jan 15 |
|
| [Hoigne's syndrome]. | 2005 Jan-Feb |
|
| Scleredema adultorum associated with hyperkeratosis. | 2005 Jan-Feb |
|
| Acute severe mitral regurgitation during first attacks of rheumatic fever: clinical spectrum, mechanisms and prognostic factors. | 2005 Jul |
|
| Ocular manifestations and treatment of syphilis. | 2005 Jul-Sep |
|
| The effectiveness of long-acting penicillin (penidur) in preventing recurrences of dermatolymphangioadenitis(DLA) and controlling skin, deep tissues, and lymph bacterial flora in patients with "filarial" lymphedema. | 2005 Jun |
|
| FDA strengthens labeling for long-acting penicillins. | 2005 Jun |
|
| Extensive annular verrucous late secondary syphilis. | 2005 Jun |
|
| Treatment for syphilis in antenatal care: compliance with the three dose standard treatment regimen. | 2005 Jun |
|
| Misclassification of the stages of syphilis: implications for surveillance. | 2005 Mar |
|
| Inadvertent use of Bicillin C-R to treat syphilis infection--Los Angeles, California, 1999-2004. | 2005 Mar 11 |
|
| Effect of testosterone replacement or duration of castration on baroreflex bradycardia in conscious rats. | 2005 Mar 30 |
|
| Is it possible to prevent rheumatic fever. | 2005 Mar-Apr |
|
| Efficacy of intramuscular penicillin in the eradication of group B streptococcal colonization at delivery. | 2005 May |
|
| Synthesis and antimycobacterial activity of ferrocenyl ethambutol analogues and ferrocenyl diamines. | 2005 May 2 |
|
| [The unusual wandering of lues. Did the patient infect himself by tongue kissing?]. | 2005 May 5 |
|
| Infection with Leishmania infantum Inhibits actinomycin D-induced apoptosis of human monocytic cell line U-937. | 2005 May-Jun |
|
| With this eruption, there is not a second to lues. | 2005 May-Jun |
|
| [Disseminated maculopapular rash in a patient with AIDS]. | 2005 Nov |
|
| A case of primary syphilis in the rectum. | 2005 Oct |
|
| Successful treatment of refractory thrombocytopenia with mycophenolate mofetil in a patient with systemic lupus erythematosus. | 2005 Oct |
|
| Antenatal syphilis screening in sub-Saharan Africa: lessons learned from Tanzania. | 2005 Sep |
|
| Azithromycin versus penicillin G benzathine for early syphilis. | 2005 Sep 22 |
|
| Single-dose azithromycin versus penicillin G benzathine for the treatment of early syphilis. | 2005 Sep 22 |
|
| Long-term use of penicillin for the treatment of chronic plaque psoriasis. | 2005 Sep-Oct |
|
| Syphilis and HIV: a review for clinicians as this centuries-old disease makes a comeback. | 2005 Summer |
|
| Azithromycin versus penicillin for early syphilis. | 2006 Jan 12 |
|
| Azithromycin versus penicillin for early syphilis. | 2006 Jan 12 |
|
| [Plaques opalines: a rare form of secondary syphilis of the oral mucous membrane]. | 2006 Jun |
Sample Use Guides
0.72g (1.2 million units) IM as a single dose as Benzathine benzylpenicillin.
0.72g Benzathine benzylpenicillin contains 0.19g of Benzathine and 0.53g of benzylpenicillin
Route of Administration:
Intramuscular
Huh-7 replicon cells were plated at 2000 cells/well in 40 mkL of culture media in 384-well plates. After overnight incubation, serially diluted BENZATHINE in 20 mkL of cell culture media were added. At 72 h post BENZATHINE treatment, plates with GFP expressing replicon cell lines were fixed with 2% paraformaldehyde (PFA) and applied for nuclei staining with 10 mkg/mL of Hoechst 33342 (Sigma Aldrich). Cells were visualized by fully automated confocal microscopy (Opera, PerkinElmer) and analyzed by in-house software. HCV RNA replication was measured by GFP expression and cytotoxicity was measured by nucleus counting.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 03:14:24 GMT 2023
by
admin
on
Sat Dec 16 03:14:24 GMT 2023
|
| Record UNII |
YY76989J2K
|
| Record Status |
Validated (UNII)
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| Record Version |
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