Tovecimig

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 13:46:53 GMT 2025` Edited by `admin` on `Wed Apr 02 13:46:53 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	YXM6C5LQ2H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Tovecimig

Official Name

English

H-gamma1 heavy chain anti-VEGFA fused to a scFvlh anti-DLL4 (1-714) [H-gamma1 heavy chain anti-VEGFA humanized (1-453) [VH (Homo sapiens IGHV3-30*02 (76.8%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.9.16] (26-33.51-59.97-112)) (1-123)-Homo sapiens IGHG1*03v

Preferred Name

English

tovecimig [INN]

Common Name

English

immunoglobulin G1-scFvlh_L-kappa, anti-[Homo sapiens VEGFA (vascular endothelial growth factor A, VEGF-A, VEGF)] and anti-[Homo sapiens DLL4 (delta-like 4)], humanized and Homo sapiens monoclonal antibody; bispecific

Common Name

English

Immunoglobulin G1, anti-(human vascular endothelial growth factor) (human-Mus musculus monoclonal rhuMAb-VEGF ?1-chain) fusion protein with peptide linker (GGGGS)3 fusion protein with immunoglobulin, anti-(human notch ligand DLL4) (human monoclonal MLCK-

Common Name

English

Code System Code Type Description

INN

13128

Created by admin on Wed Apr 02 13:46:53 GMT 2025 , Edited by admin on Wed Apr 02 13:46:53 GMT 2025

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CAS

2923284-73-3

Created by admin on Wed Apr 02 13:46:53 GMT 2025 , Edited by admin on Wed Apr 02 13:46:53 GMT 2025

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NCI_THESAURUS

C185865

Created by admin on Wed Apr 02 13:46:53 GMT 2025 , Edited by admin on Wed Apr 02 13:46:53 GMT 2025

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FDA UNII

YXM6C5LQ2H

Created by admin on Wed Apr 02 13:46:53 GMT 2025 , Edited by admin on Wed Apr 02 13:46:53 GMT 2025

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From	To
1_235	2_235
1_232	2_232
2_226	4_214
1_226	3_214
4_134	4_194
4_23	4_88
3_134	3_194
3_23	3_88
2_620	2_694
2_571	2_642
2_490	2_557
2_373	2_431
2_267	2_327
2_150	2_206
2_22	2_96
1_620	1_694
1_571	1_642
1_490	1_557
1_373	1_431
1_267	1_327
1_150	1_206
1_22	1_96