DELEQUAMINE HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C18H26N2O3S.ClH
Molecular Weight	386.937
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.[H][C@]12CCCN([C@@]1([H])C[C@]3([H])N(CCC4=C3C=CC(OC)=C4)C2)S(C)(=O)=O

InChI

InChIKey=ITJOISLXCMAIOC-CVLULELNSA-N

InChI=1S/C18H26N2O3S.ClH/c1-23-15-5-6-16-13(10-15)7-9-19-12-14-4-3-8-20(24(2,21)22)17(14)11-18(16)19;/h5-6,10,14,17-18H,3-4,7-9,11-12H2,1-2H3;1H/t14-,17+,18+;/m1./s1

HIDE SMILES / InChI

Molecular Formula	C18H26N2O3S
Molecular Weight	350.476
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2570150 | https://www.ncbi.nlm.nih.gov/pubmed/7871091

Delequamine is a selective antagonist of alpha2 adrenoreceptor, developed by Syntex Research. The compound was investigated for the treatment of erectile dysfunction and was modestly effective in younger (less than 45 years) subjects.

Approval Year

PubMed

Title	Date	PubMed
The alpha 2-adrenoceptor antagonist idazoxan reverses catalepsy induced by haloperidol in rats independent of striatal dopamine release: role of serotonergic mechanisms.	2003 May	12644843

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:20:16 GMT 2023` Edited by `admin` on `Fri Dec 15 17:20:16 GMT 2023`
Record UNII	YV5E1TYM8Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DELEQUAMINE HYDROCHLORIDE

Official Name

English

DELEQUAMINE HCL

Common Name

English

Delequamine hydrochloride [WHO-DD]

Common Name

English

RS-15385-197

Code

English

(8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-Decahydro-3-methoxy-12-(methylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridine monohydrochloride

Common Name

English

6H-ISOQUINO(2,1-G)(1,6)NAPHTHYRIDINE, 5,8,8A,9,10,11,12,12A,13,13A-DECAHYDRO-3-METHOXY-12-(METHYLSULFONYL)-, MONOHYDROCHLORIDE, (8AR-(8A.ALPHA.,12A.ALPHA.,13A.ALPHA.))-

Common Name

English

DELEQUAMINE HYDROCHLORIDE [USAN]

Common Name

English

Code System Code Type Description

PUBCHEM

168898