Equecabtagene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 19:20:37 GMT 2023` Edited by `admin` on `Sat Dec 16 19:20:37 GMT 2023`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	BLOOD
Fraction Material Type	CELL
Fraction Name	CD3+ enriched T lymphocytes
Record UNII	YTJ3XRJ4ZN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Equecabtagene Autoleucel

Official Name

English

autologous T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector encoding a chimeric antigen receptor (CAR) targeting human B cell maturation antigen (BCMA)

Common Name

English

equecabtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C185123

Created by admin on Sat Dec 16 19:20:37 GMT 2023 , Edited by admin on Sat Dec 16 19:20:37 GMT 2023

PRIMARY

INN

12142

Created by admin on Sat Dec 16 19:20:37 GMT 2023 , Edited by admin on Sat Dec 16 19:20:37 GMT 2023

PRIMARY

FDA UNII

YTJ3XRJ4ZN

Created by admin on Sat Dec 16 19:20:37 GMT 2023 , Edited by admin on Sat Dec 16 19:20:37 GMT 2023

PRIMARY

Related Record Type Details


					PK6VHJAIBD

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					YTJ3XRJ4ZN

Equecabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
CULTURE	EXPANSION	BIOLOGICAL	HUMAN INTERLEUKIN-2	FNO32LO217
LENTIVIRAL TRANSFECTION	TRANSFECTION	BIOLOGICAL	Equecabtagene autoleucel lentiviral vector	KFK55U2UXG
CULTURE	ACTIVATOR	BIOLOGICAL	UNSPECIFIED SUBSTANCE	4e4ac683

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					Equecabtagene autoleucel CAR-T receptor	FWX6QW8JH8
INSERTED GENE EXPRESSION VECTOR					Equecabtagene autoleucel transgene insert	L5HB4J52GS

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
ENHANCED ACTIVATION	BIOLOGICAL		`P050J5FWC5` INTERFERON GAMMA