U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 19:20:37 GMT 2023
Edited
by admin
on Sat Dec 16 19:20:37 GMT 2023
Source Materials Class ORGANISM
Source Materials Type AUTOLOGOUS HUMAN
Source Materials State LIVE GENETICALLY MODIFIED
Source Materials Parent
Part BLOOD
Fraction Material Type CELL
Fraction Name CD3+ enriched T lymphocytes
Record UNII
YTJ3XRJ4ZN
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Equecabtagene Autoleucel
INN  
Official Name English
autologous T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector encoding a chimeric antigen receptor (CAR) targeting human B cell maturation antigen (BCMA)
Common Name English
equecabtagene autoleucel [INN]
Common Name English
Code System Code Type Description
NCI_THESAURUS
C185123
Created by admin on Sat Dec 16 19:20:37 GMT 2023 , Edited by admin on Sat Dec 16 19:20:37 GMT 2023
PRIMARY
INN
12142
Created by admin on Sat Dec 16 19:20:37 GMT 2023 , Edited by admin on Sat Dec 16 19:20:37 GMT 2023
PRIMARY
FDA UNII
YTJ3XRJ4ZN
Created by admin on Sat Dec 16 19:20:37 GMT 2023 , Edited by admin on Sat Dec 16 19:20:37 GMT 2023
PRIMARY
Related Record Type Details
TARGET->CYTOTOXIC T-CELL
Related Record Type Details
ACTIVE MOIETY

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID
CULTURE EXPANSION BIOLOGICAL HUMAN INTERLEUKIN-2 FNO32LO217
LENTIVIRAL TRANSFECTION TRANSFECTION BIOLOGICAL Equecabtagene autoleucel lentiviral vector KFK55U2UXG
CULTURE ACTIVATOR BIOLOGICAL UNSPECIFIED SUBSTANCE 4e4ac683

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR EXPRESSED PROTEIN Equecabtagene autoleucel CAR-T receptor FWX6QW8JH8
INSERTED GENE EXPRESSION VECTOR Equecabtagene autoleucel transgene insert L5HB4J52GS
Name Property Type Amount Referenced Substance Defining Parameters References
ENHANCED ACTIVATION BIOLOGICAL