Equecabtagene Autoleucel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 15:11:06 GMT 2025` Edited by `admin` on `Wed Apr 02 15:11:06 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Material Type	cell
Fraction Name	cd3+ enriched t lymphocytes
Record UNII	YTJ3XRJ4ZN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Equecabtagene autoleucel [WHO-DD]

Preferred Name

English

Equecabtagene Autoleucel

Official Name

English

autologous T lymphocytes obtained from peripheral blood mononuclear cells by leukapheresis, transduced with a self-inactivating, non-replicating lentiviral vector encoding a chimeric antigen receptor (CAR) targeting human B cell maturation antigen (BCMA)

Common Name

English

equecabtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

SMS_ID

300000047259

Created by admin on Wed Apr 02 15:11:06 GMT 2025 , Edited by admin on Wed Apr 02 15:11:06 GMT 2025

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NCI_THESAURUS

C185123

Created by admin on Wed Apr 02 15:11:06 GMT 2025 , Edited by admin on Wed Apr 02 15:11:06 GMT 2025

PRIMARY

INN

12142

Created by admin on Wed Apr 02 15:11:06 GMT 2025 , Edited by admin on Wed Apr 02 15:11:06 GMT 2025

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FDA UNII

YTJ3XRJ4ZN

Created by admin on Wed Apr 02 15:11:06 GMT 2025 , Edited by admin on Wed Apr 02 15:11:06 GMT 2025

PRIMARY

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TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					YTJ3XRJ4ZN

Equecabtagene Autoleucel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
CULTURE	EXPANSION	BIOLOGICAL	HUMAN INTERLEUKIN-2	FNO32LO217
LENTIVIRAL TRANSFECTION	TRANSFECTION	BIOLOGICAL	Equecabtagene autoleucel lentiviral vector	KFK55U2UXG
CULTURE	ACTIVATOR	BIOLOGICAL	ANTI-CD3/ANTI-CD28 4.5 MICRON MAGNETIC BEADS	PA28ZKP50M

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					Equecabtagene autoleucel CAR-T receptor	FWX6QW8JH8
INSERTED GENE EXPRESSION VECTOR					Equecabtagene autoleucel transgene insert	L5HB4J52GS

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
ENHANCED ACTIVATION	BIOLOGICAL		`P050J5FWC5` INTERFERON GAMMA