Details
Stereochemistry | ACHIRAL |
Molecular Formula | C6H9NO2 |
Molecular Weight | 127.1412 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=CCNCC1
InChI
InChIKey=KRVDMABBKYMBHG-UHFFFAOYSA-N
InChI=1S/C6H9NO2/c8-6(9)5-1-3-7-4-2-5/h1,7H,2-4H2,(H,8,9)
Molecular Formula | C6H9NO2 |
Molecular Weight | 127.1412 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL1907607 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19535226 |
PubMed
Title | Date | PubMed |
---|---|---|
GABAA receptor subunit interactions important for benzodiazepine and zinc modulation: a patch-clamp and single cell RT-PCR study. | 2001 May |
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Post-episode depression of GABAergic transmission in spinal neurons of the chick embryo. | 2001 May |
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Seizures induced by intracerebral administration of pyridoxal-5'-phosphate: effect of GABAergic drugs and glutamate receptor antagonists. | 2001 Oct |
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Potentiation of GABA(A) receptor agonists by GABA uptake inhibitors in the rat ventral midbrain. | 2001 Sep 28 |
|
GABA(A) receptor ligands and their therapeutic potentials. | 2002 Aug |
|
Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling. | 2002 Jun 6 |
|
Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain. | 2002 May |
|
Nociception attenuates parasympathetic but not sympathetic baroreflex via NK1 receptors in the rat nucleus tractus solitarii. | 2003 Sep 1 |
|
Spontaneous REM sleep is modulated by the activation of the pedunculopontine tegmental GABAB receptors in the freely moving rat. | 2004 Apr |
|
Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus. | 2004 Feb |
|
Alpha 2- and beta-adrenoceptors differentially modulate GABAA- and GABAB-mediated inhibition of red nucleus neuronal firing. | 2004 Feb |
|
Stimulation of TM3 Leydig cell proliferation via GABA(A) receptors: a new role for testicular GABA. | 2004 Mar 24 |
|
Insights into GABA receptor signalling in TM3 Leydig cells. | 2005 |
|
Respiratory rhythm entrainment by somatic afferent stimulation. | 2005 Feb 23 |
|
Modulation of GABAergic synaptic transmission by terminal nicotinic acetylcholine receptors in the central autonomic nucleus of the neonatal rat spinal cord. | 2006 Jul |
|
Subthalamic stimulation evokes complex EPSCs in the rat substantia nigra pars reticulata in vitro. | 2006 Jun 15 |
|
A spinal vasopressinergic mechanism mediates hyperosmolality-induced sympathoexcitation. | 2006 Oct 15 |
|
Timing of the developmental switch in GABA(A) mediated signaling from excitation to inhibition in CA3 rat hippocampus using gramicidin perforated patch and extracellular recordings. | 2007 |
|
Endogenous GABA and glutamate finely tune the bursting of olfactory bulb external tufted cells. | 2007 Aug |
|
Molecular cloning of a GABA receptor subunit from Laodelphax striatella (Fallén) and patch clamp analysis of the homo-oligomeric receptors expressed in a Drosophila cell line. | 2007 Dec |
|
Expression of gamma-aminobutyric acid receptor (subtype A) in prostate cancer. | 2008 |
|
Regulation of cardiac sympathetic afferent reflex by GABA(A) and GABA(B) receptors in paraventricular nucleus in rats. | 2008 Jun |
|
The role of GABA(A) receptors in the control of transient lower oesophageal sphincter relaxations in the dog. | 2008 Mar |
|
Effect of GABA A receptor activation on UT-coupled signaling pathways in rat cortical astrocytes. | 2008 May |
|
"Diversity oriented synthesis" of functionalized chiral tetrahydropyridines: potential GABA receptor agonists and azasugars from natural amino acids via a sequential Baylis-Hillman reaction and RCM protocol. | 2008 May-Jun |
|
Inhibitory actions of the gamma-aminobutyric acid in pediatric Sturge-Weber syndrome. | 2009 Aug |
|
Population patch-clamp electrophysiology analysis of recombinant GABAA alpha1beta3gamma2 channels expressed in HEK-293 cells. | 2009 Aug |
|
Potentiating effect of eszopiclone on GABA(A) receptor-mediated responses in pedunculopontine neurons. | 2009 Jul |
|
Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus. | 2009 May 27 |
|
Nucleus of solitary tract mediates cardiac sympathetic afferent reflex in rats. | 2009 Nov |
|
Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures. | 2009 Oct |
|
Control of GABA Release at Mossy Fiber-CA3 Connections in the Developing Hippocampus. | 2010 |
|
Molecular characterization of agonists that bind to an insect GABA receptor. | 2010 Apr 6 |
|
In the adult hippocampus, chronic nerve growth factor deprivation shifts GABAergic signaling from the hyperpolarizing to the depolarizing direction. | 2010 Jan 20 |
|
A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons. | 2010 Jul |
|
The K+-Cl cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus. | 2010 May 1 |
|
Loss of leptin receptors on hypothalamic POMC neurons alters synaptic inhibition. | 2010 Nov |
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 19:49:49 GMT 2023
by
admin
on
Fri Dec 15 19:49:49 GMT 2023
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Record UNII |
YTF580771Y
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Record Status |
Validated (UNII)
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Record Version |
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-
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64603-90-3
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YTF580771Y
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C015300
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3765
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DTXSID30214855
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Isoguvacine
Created by
admin on Fri Dec 15 19:49:49 GMT 2023 , Edited by admin on Fri Dec 15 19:49:49 GMT 2023
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Related Record | Type | Details | ||
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TARGET -> AGONIST |
Binding Assay
IC50
|