Moflerafusp alfa

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 14:07:07 GMT 2025` Edited by `admin` on `Wed Apr 02 14:07:07 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	YT7P5NE9UW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Moflerafusp alfa

Official Name

English

1-125-Signal regulatory protein ? [80-alanine] (human variant 2) fusion protein with peptide linker ((GGGGS)3) fusion protein with immunoglobulin G1 [442-alanine,477-alanine,478-alanine] anti-(human programmed death-ligand PD-L1) (human-Mus musculus mono

Preferred Name

English

moflerafusp alfa [INN]

Common Name

English

human signal regulatory protein alpha (SIRP?) variant V2 D1 domain, (SIRP? V2D1) fragment 30-154 (1-125 in the actual sequence, comprising the first two extracellular loops of the D1 domain) variant (N<sup>110</sup>>A<sup>80</sup>) fused via peptide link

Common Name

English

Code System Code Type Description

INN

13348

Created by admin on Wed Apr 02 14:07:07 GMT 2025 , Edited by admin on Wed Apr 02 14:07:07 GMT 2025

PRIMARY

CAS

2983848-20-8

Created by admin on Wed Apr 02 14:07:07 GMT 2025 , Edited by admin on Wed Apr 02 14:07:07 GMT 2025

PRIMARY

FDA UNII

YT7P5NE9UW

Created by admin on Wed Apr 02 14:07:07 GMT 2025 , Edited by admin on Wed Apr 02 14:07:07 GMT 2025

PRIMARY

From	To
4_134	4_194
4_23	4_88
3_134	3_194
3_23	3_88
2_364	4_214
1_373	2_373
1_370	2_370
1_364	3_214
1_511	1_569
2_511	2_569
1_405	1_465
2_405	2_465
1_288	1_344
2_288	2_344
1_162	1_236
2_162	2_236
1_25	1_91
2_25	2_91

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_441
N	2_441

Related Record Type Details


					L4766ELH5T

PROGRAMMED CELL DEATH 1 LIGAND 1

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					YT7P5NE9UW

Moflerafusp alfa

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL		C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL