SOTEVTAMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 06:43:23 GMT 2025` Edited by `admin` on `Wed Apr 02 06:43:23 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG2
Sequence Origin	HUMANIZED
Sequence Type	COMPLETE
Record UNII	YQ3YJK67AF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SOTEVTAMAB

Official Name

English

AB 16B5 [WHO-DD]

Preferred Name

English

sotevtamab [INN]

Common Name

English

IMMUNOGLOBULIN G2, ANTI-(HUMAN CLUSTERIN .BETA.-CHAIN) (HUMAN-MUS MUSCULUS MONOCLONAL AB-16B5 .GAMMA.2-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL AB-16B5 .KAPPA.-CHAIN, DIMER

Common Name

English

Code System Code Type Description

SMS_ID

300000039130

Created by admin on Wed Apr 02 06:43:23 GMT 2025 , Edited by admin on Wed Apr 02 06:43:23 GMT 2025

PRIMARY

INN

11666

Created by admin on Wed Apr 02 06:43:23 GMT 2025 , Edited by admin on Wed Apr 02 06:43:23 GMT 2025

PRIMARY

CAS

2411526-47-9

Created by admin on Wed Apr 02 06:43:23 GMT 2025 , Edited by admin on Wed Apr 02 06:43:23 GMT 2025

PRIMARY

FDA UNII

YQ3YJK67AF

Created by admin on Wed Apr 02 06:43:23 GMT 2025 , Edited by admin on Wed Apr 02 06:43:23 GMT 2025

PRIMARY

NCI_THESAURUS

C121778

Created by admin on Wed Apr 02 06:43:23 GMT 2025 , Edited by admin on Wed Apr 02 06:43:23 GMT 2025

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From	To
1_22	1_96
1_363	1_421
2_22	2_96
2_131	4_219
2_144	2_200
1_131	3_219
2_257	2_317
2_363	2_421
3_23	3_94
3_139	3_199
1_144	1_200
4_23	4_94
4_139	4_199
1_219	2_219
1_220	2_220
1_223	2_223
1_226	2_226
1_257	1_317

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_293
N	2_293

Related Record Type Details


					NEH8IKS25R

CLUSTERIN

TARGET->LIGAND

Amount:

Related Record Type Details


					YQ3YJK67AF

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_443] [2_443]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL