TRIBENDIMIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C28H32N6
Molecular Weight	452.5939
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	4
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)C(\C)=N\C1=CC=C(C=C1)\N=C\C2=CC=C(C=C2)\C=N\C3=CC=C(C=C3)\N=C(/C)N(C)C

InChI

InChIKey=XOIOGKHKNQYULW-HTNNXBMUSA-N

InChI=1S/C28H32N6/c1-21(33(3)4)31-27-15-11-25(12-16-27)29-19-23-7-9-24(10-8-23)20-30-26-13-17-28(18-14-26)32-22(2)34(5)6/h7-20H,1-6H3/b29-19+,30-20+,31-21+,32-22+

HIDE SMILES / InChI

Molecular Formula	C28H32N6
Molecular Weight	452.5939
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	4
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Ascaris lumbricoides: an overview of therapeutic targets.	2010-10	20701574
Update on the diagnosis and treatment of food-borne trematode infections.	2010-10	20683264
Effect of artemether, artesunate, OZ78, praziquantel, and tribendimidine alone or in combination chemotherapy on the tegument of Clonorchis sinensis.	2010-09	20416396
[Effect of six anthelmintics in oral treatment of mice infected with Armillifer agkistrodontis nymphs].	2010-08	21137313
[Treatment of rats infected with Clonorchis sinensis using clinical administration regimens of tribendimidine, praziquantel and artesunate].	2010-06-30	20806495
"Manifesto" for advancing the control and elimination of neglected tropical diseases.	2010-05-25	20520793
Bacillus thuringiensis Cry5B protein is highly efficacious as a single-dose therapy against an intestinal roundworm infection in mice.	2010-03-02	20209154
The effect of tribendimidine and its metabolites against Necator americanus in golden hamsters and Nippostrongylus braziliensis in rats.	2010-03	20155372
[Efficacy of tribendimidine and albendazole in treating mice infected with Trichinella spiralis].	2010-02	20411740
Metabolism and disposition of tribendimidine and its metabolites in healthy Chinese volunteers.	2010	20698716
The drugs we have and the drugs we need against major helminth infections.	2010	20627144
The in vitro and in vivo effect of tribendimidine and its metabolites against Clonorchis sinensis.	2009-11	19655171
The control of hookworm infection in China.	2009-09-24	19775473
The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist.	2009-08-11	19668355
[Therapeutic effect of tribendimidine, artesunate and praziquantel administered to hamsters infected with Clonorchis sinensis].	2009-06	19852361
[Experimental study progress on tribendimidine, artemether and artesunate against Clonorchis sinensis and other trematodes].	2009-02-28	19459505
Pharmacotherapy of helminth infection.	2009-02	19191680
Effect of single-dose oral artemether and tribendimidine on the tegument of adult Clonorchis sinensis in rats.	2009-02	18975004
[Effect of tribendimidine, artesunate, artemether and praziquantel, administered intragastrically at single, multiple or combined doses, to rats infected with Clonorchis sinensis].	2008-10-30	19160575
Developing novel anthelmintics from plant cysteine proteinases.	2008-09-01	18761736
Metabolic profiling of an Echinostoma caproni infection in the mouse for biomarker discovery.	2008-07-02	18596973
Artemether, artesunate, praziquantel and tribendimidine administered singly at different dosages against Clonorchis sinensis: a comparative in vivo study.	2008-04	18308285
Opisthorchis viverrini: efficacy and tegumental alterations following administration of tribendimidine in vivo and in vitro.	2008-03	18172689
[Tribendimidine enteric coated tablet in treatment of 1,292 cases with intestinal nematode infection--a phase IV clinical trial].	2008-02-28	18637576
Artemether and tribendimidine lack activity in experimental treatment of Paragonimus westermani in the dog.	2008-02	18066711
Strongyloides ratti: in vitro and in vivo activity of tribendimidine.	2008-01-23	18235851
Tribendimidine and albendazole for treating soil-transmitted helminths, Strongyloides stercoralis and Taenia spp.: open-label randomized trial.	2008	18923706
[Clinical observation on 899 children infected with intestinal nematodes and treated with tribendimidine enteric coated tablets].	2007-10	18441987
[Development of novel antihelminthic therapies].	2006-08	16999038
Effect of tribendimidine on adult Echinostoma caproni harbored in mice, including scanning electron microscopic observations.	2006-08	16995405
New technologies for the control of human hookworm infection.	2006-07	16709466
[Effect of a novel drug--enteric coated tribendimidine in the treatment of intestinal nematode infections].	2006-02-28	16866136
Necator americanus: optimization of the golden hamster model for testing anthelmintic drugs.	2005-12	16198341
Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China.	2005-04	15777691
[Tribendimidine--a new broad-spectrum drug against intestinal helminths].	2004-10	15830892

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:11:53 GMT 2025` Edited by `admin` on `Mon Mar 31 19:11:53 GMT 2025`
Record UNII	YO6SOD6ZTJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRIBENDIMIDINE

Common Name

English

ETHANIMIDAMIDE, N',N'''-(1,4-PHENYLENEBIS(METHYLIDYNENITRILO-4,1-PHENYLENE))BIS(N,N-DIMETHYL-

Preferred Name

English

TRIBENDIMIDIN

Common Name

English

Tribendimidine [WHO-DD]

Common Name

English

Code System Code Type Description

PUBCHEM

3086564