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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 13:15:40 GMT 2025
Edited
by admin
on Wed Apr 02 13:15:40 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
YN4XWR5BUJ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LM-108
Preferred Name English
Cafelkibart
INN  
Official Name English
LM108
Code English
cafelkibart [INN]
Common Name English
Immunoglobulin G1 [245-aspartic acid,338-glutamic acid], anti-(human CC chemokine receptor CCR8) (human-Mus musculus monoclonal LM-108 ?1-chain), disulfide with human-Mus musculus monoclonal LM-108 ?-chain, dimer
Common Name English
H-gamma1 heavy chain (1-453) [VH Musmus/Homsap (Mus musculus IGHV10-1*02 (92.9%) -(IGHD) -IGHJ4*01 (93.8%) S123>L (118)/Homo sapiens IGHV3-73*01 (88.0%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.10.14] (26-33.51-60.99-112)) (1-123) -Homo sapiens IGHG1*01, G1
Common Name English
immunoglobulin G1-kappa, anti-[Homo sapiens CCR8 (C-C motif chemokine receptor 8, CKR-L1, CDw198)]
Common Name English
Code System Code Type Description
INN
13048
Created by admin on Wed Apr 02 13:15:40 GMT 2025 , Edited by admin on Wed Apr 02 13:15:40 GMT 2025
PRIMARY
SMS_ID
300000054611
Created by admin on Wed Apr 02 13:15:40 GMT 2025 , Edited by admin on Wed Apr 02 13:15:40 GMT 2025
PRIMARY
FDA UNII
YN4XWR5BUJ
Created by admin on Wed Apr 02 13:15:40 GMT 2025 , Edited by admin on Wed Apr 02 13:15:40 GMT 2025
PRIMARY
CAS
2851855-89-3
Created by admin on Wed Apr 02 13:15:40 GMT 2025 , Edited by admin on Wed Apr 02 13:15:40 GMT 2025
PRIMARY
NCI_THESAURUS
C186374
Created by admin on Wed Apr 02 13:15:40 GMT 2025 , Edited by admin on Wed Apr 02 13:15:40 GMT 2025
PRIMARY
From To
1_22 1_98
2_22 2_98
2_150 2_206
2_226 4_219
2_267 2_327
1_150 1_206
2_373 2_431
3_23 3_93
3_139 3_199
4_23 4_93
4_139 4_199
1_226 3_219
1_232 2_232
1_235 2_235
1_267 1_327
1_373 1_431
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_303
N 2_303
Related Record Type Details
Cafelkibart
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_1] [2_1] N-TERMINUS Amount: PIDOLIC ACID SZB83O1W42
AMINO ACID REMOVAL [1_453] [2_453] C-TERMINUS Amount: LYSINE K3Z4F929H6
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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