Emideltide or delta-sleep-inducing peptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) is a nonapeptide originally isolated from rabbit cerebral venous blood. It promotes sleep and this has been demonstrated in rabbits, mice, rats, cats and human beings. Emideltide showed significant and specific enhancement/induction of delta and spindle electroencephalogram patterns. In addition to sleep, the peptide also has been observed to affect electrophysiological activity, neurotransmitter levels in the brain, circadian and locomotor patterns, hormonal levels, psychological performance, and the activity of neuropharmacological drugs including their withdrawal.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. | 1977 Mar |
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| Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes. A clinical pilot study. | 1984 |
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| The influence of the delta-sleep-inducing peptide on convulsive activity. | 1993 Sep-Oct |
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| Effect of intranigral dosage with delta-sleep-inducing peptide and its analogs on movement and convulsive activity in rats. | 1996 Nov-Dec |
| Substance Class |
Protein
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| Protein Type | PEPTIDE |
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| Sequence Type | COMPLETE |
| Record UNII |
YN28Z5YZ73
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| Record Status |
Validated (UNII)
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WIKIPEDIA |
Designer-drugs-EMIDELTIDE
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NCI_THESAURUS |
C29756
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m4775
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Delta-sleep-inducing peptide
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ACTIVE MOIETY |
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| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
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| Molecular Formula | CHEMICAL |
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