Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C5H8FNO2 |
| Molecular Weight | 133.1209 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
N[C@]1(C[C@H](F)C1)C(O)=O
InChI
InChIKey=NTEDWGYJNHZKQW-IWLYVCSRSA-N
InChI=1S/C5H8FNO2/c6-3-1-5(7,2-3)4(8)9/h3H,1-2,7H2,(H,8,9)/t3-,5-
| Molecular Formula | C5H8FNO2 |
| Molecular Weight | 133.1209 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
FLUCICLOVINE is a synthetic amino acid which is transported across mammalian cell membranes by amino acid transporters such as LAT-1 and ASCT2. Its 18F radiolabelled form is a positron emission tomography (PET) tracer targeting prostate cancer cells where aforementioned transporters are known to be upregulated, providing a mechanism for the enhanced accumulation of the tracer in these cells.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Improved synthesis of anti-[18F]FACBC: improved preparation of labeling precursor and automated radiosynthesis. | 2003 Jun |
|
| Initial experience with the radiotracer anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid with PET/CT in prostate carcinoma. | 2007 Jan |
|
| A preliminary study of anti-1-amino-3-18F-fluorocyclobutyl-1-carboxylic acid for the detection of prostate cancer. | 2007 Jan |
|
| The impact of urinary excretion of (18)F-labeled choline analogs. | 2007 Jul |
|
| Biodistribution and radiation dosimetry of the synthetic nonmetabolized amino acid analogue anti-18F-FACBC in humans. | 2007 Jun |
|
| Case study of anti-1-amino-3-F-18 fluorocyclobutane-1-carboxylic acid (anti-[F-18] FACBC) to guide prostate cancer radiotherapy target design. | 2009 May |
|
| Synthesis and biological evaluation of anti-1-amino-2-[18F]fluoro-cyclobutyl-1-carboxylic acid (anti-2-[18F]FACBC) in rat 9L gliosarcoma. | 2010 Apr 1 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:10:43 UTC 2023
by
admin
on
Fri Dec 15 18:10:43 UTC 2023
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| Record UNII |
YKG0YF688X
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| Record Status |
Validated (UNII)
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| Record Version |
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YKG0YF688X
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