Aletekitug

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 12:52:02 GMT 2025` Edited by `admin` on `Wed Apr 02 12:52:02 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	hUMANIZED
Sequence Type	COMPLETE
Record UNII	YJ4XZ74SWG
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Aletekitug

Official Name

English

H-gamma1 heavy chain humanized (1-456) [VH (Homo sapiens IGHV1-24*01 (82.7%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.8.19] (26-33.51-58.97-115)) (1-126) -Homo sapiens IGHG1*01 (100%) G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (223) (127-224), hinge 1-15 (225

Preferred Name

English

aletekitug [INN]

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens IL18 (interleukin 18, IL-18, interferon gamma-inducing factor, IGIF, interleukin-1 gamma, IL-1G, IL1F4)], humanized monoclonal antibody

Common Name

English

Code System Code Type Description

FDA UNII

YJ4XZ74SWG

Created by admin on Wed Apr 02 12:52:02 GMT 2025 , Edited by admin on Wed Apr 02 12:52:02 GMT 2025

PRIMARY

CAS

2923284-67-5

Created by admin on Wed Apr 02 12:52:02 GMT 2025 , Edited by admin on Wed Apr 02 12:52:02 GMT 2025

PRIMARY

INN

13155

Created by admin on Wed Apr 02 12:52:02 GMT 2025 , Edited by admin on Wed Apr 02 12:52:02 GMT 2025

PRIMARY

NCI_THESAURUS

C211830

Created by admin on Wed Apr 02 12:52:02 GMT 2025 , Edited by admin on Wed Apr 02 12:52:02 GMT 2025

PRIMARY

SMS_ID

300000047696

Created by admin on Wed Apr 02 12:52:02 GMT 2025 , Edited by admin on Wed Apr 02 12:52:02 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_153	2_209
2_229	4_214
2_270	2_330
1_153	1_209
2_376	2_434
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_229	3_214
1_235	2_235
1_238	2_238
1_270	1_330
1_376	1_434

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_306
N	2_306

Related Record Type Details


					YJ4XZ74SWG

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_456] [2_456]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL