ISIS-463588

Investigational

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 05:21:56 GMT 2025` Edited by `admin` on `Wed Apr 02 05:21:56 GMT 2025`
Nucleic Acid Type	OLIGONUCLEOTIDE
Sequence Type	COMPLETE
Record UNII	YJ4APB5MQC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IONIS-FGFR4RX

Preferred Name

English

ISIS-463588

Code

English

DNA, D(P-THIO)((2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-M5C-T-M5C-A-G-M5C-A-G-G-A-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))

Systematic Name

English

ISIS-FGFR4RX

Code

English

Code System Code Type Description

FDA UNII

YJ4APB5MQC

Created by admin on Wed Apr 02 05:21:56 GMT 2025 , Edited by admin on Wed Apr 02 05:21:56 GMT 2025

PRIMARY

CAS

1416376-17-4

Created by admin on Wed Apr 02 05:21:56 GMT 2025 , Edited by admin on Wed Apr 02 05:21:56 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_6-1_15	10 / 20
2'-O-Methoxyethyl ribose	1_1-1_5;1_16-1_20	10 / 20

Linkage	Site Range	Site Count
Phosporothioate	1_2-1_20	19 / 19

Related Record Type Details


					3F84ING33L

FIBROBLAST GROWTH FACTOR RECEPTOR 4

TARGET->INHIBITOR OF EXPRESSION

Related Record Type Details


					YJ4APB5MQC

ISIS-463588

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION	[1_2] [1_4] [1_6] [1_8] [1_11] [1_16] [1_17] [1_18] [1_19] [1_20]	SITE_SPECIFIC			2'-O-(2-METHOXYETHYL)-5-METHYLCYTIDINE	AOQ54IZZ6J

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL