DAUNORUBICINOL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H31NO10
Molecular Weight	529.5357
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=C2C(=O)C3=C(O)C4=C(C[C@](O)(C[C@@H]4O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)[C@H](C)O)C(O)=C3C(=O)C2=CC=C1

InChI

InChIKey=HJEZFVLKJYFNQW-PRFXOSGESA-N

InChI=1S/C27H31NO10/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6,10-11,14,16-17,22,29-30,32,34-35H,7-9,28H2,1-3H3/t10-,11-,14-,16-,17-,22+,27-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C27H31NO10
Molecular Weight	529.5357
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Curcumin is a tight-binding inhibitor of the most efficient human daunorubicin reductase--Carbonyl reductase 1.	2015-06-05	25541467
AKR1B10 induces cell resistance to daunorubicin and idarubicin by reducing C13 ketonic group.	2011-08-15	21640744
Daunorubicin metabolism in leukemic cells isolated from patients with acute myeloid leukemia.	2010-12	20670211
Cancer biomarker AKR1B10 and carbonyl metabolism.	2009-03-16	19028477
Two allelic variants of aldo-keto reductase 1A1 exhibit reduced in vitro metabolism of daunorubicin.	2008-05	18276838

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:23:49 GMT 2025` Edited by `admin` on `Mon Mar 31 18:23:49 GMT 2025`
Record UNII	YDU8YIP30L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

13-DIHYDRODAUNOMYCIN

Preferred Name

English

DAUNORUBICINOL

Common Name

English

LEUKAEMOMYCIN D

Common Name

English

DUBORIMYCIN

Common Name

English

13-DIHYDRODAUNORUBICIN

Common Name

English

5,12-NAPHTHACENEDIONE, 10-((3-AMINO-2,3,6-TRIDEOXY-.ALPHA.-L-LYXO-HEXOPYRANOSYL)OXY)-7,8,9,10-TETRAHYDRO-6,8,11-TRIHYDROXY-8-((1S)-1-HYDROXYETHYL)-1-METHOXY-, (8S,10S)-

Systematic Name

English

DAUNOMYCINOL

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1594