PROPENZOLATE HYDROCHLORIDE

Details

Stereochemistry	EPIMERIC
Molecular Formula	C20H29NO3.ClH
Molecular Weight	367.91
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CN1CCC[C@H](C1)OC(=O)C(O)(C2CCCCC2)C3=CC=CC=C3

InChI

InChIKey=LBKCCRHBZAWYOP-HUVSLODASA-N

InChI=1S/C20H29NO3.ClH/c1-21-14-8-13-18(15-21)24-19(22)20(23,16-9-4-2-5-10-16)17-11-6-3-7-12-17;/h2,4-5,9-10,17-18,23H,3,6-8,11-15H2,1H3;1H/t18-,20?;/m1./s1

HIDE SMILES / InChI

Molecular Formula	C20H29NO3
Molecular Weight	331.4492
Charge	0
Count

Stereochemistry	EPIMERIC
Additional Stereochemistry	No
Defined Stereocenters	1 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6079700 | https://www.ncbi.nlm.nih.gov/pubmed/13885723

Propenzolate is a pyridine derivative patented by National Research Development Corp. as an anticholinergic agent. Propenzolate is effective antidotes to the cholinesterase-inhibiting action of various organophosphorus compounds. In clinical trials, Propenzolate has an activity that decreases to some extent the secretion of hydrochloric acid and the volume of gastric juice. Adverse effects, including nausea, vomiting, weakness, and drowsiness, as well as xerostomia and cycloplegia, are observed in a high percentage of patients receiving 0.5 to 1.0 mg. every 12 hours.

Originator

Approval Year

PubMed

Title	Date	PubMed
Gastrointestinal motility in man: a study of propenzolate.	1967 Sep	6079700

Patents

Sample Use Guides

In Vivo Use Guide

0.5 to 1.0 mg. every 12 hours.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:08:49 GMT 2023` Edited by `admin` on `Fri Dec 15 19:08:49 GMT 2023`
Record UNII	YCZ9J99C72
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PROPENZOLATE HYDROCHLORIDE

Official Name

English

NDR-263

Code

English

DELINAL

Brand Name

English

BENZENEACETIC ACID, .ALPHA.-CYCLOHEXYL-.ALPHA.-HYDROXY-, (±)-, (+)-1-METHYL-3-PIPERIDINYL ESTER, HYDROCHLORIDE

Common Name

English

NDR 263

Code

English

PROPENZOLATE HYDROCHLORIDE [MI]

Common Name

English

OXYCLIPINE HYDROCHLORIDE

Common Name

English

PROPENZOLATE HYDROCHLORIDE [USAN]

Common Name

English

(+)-1-METHYL-3-PIPERIDYL (±)-.ALPHA.-PHENYLCYCLOHEXANEGLYCOLATE HYDROCHLORIDE

Systematic Name

English

Code System Code Type Description

MERCK INDEX

m438