CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 6

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 21:49:14 GMT 2025` Edited by `admin` on `Tue Apr 01 21:49:14 GMT 2025`
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	YCK8BIF36J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CD66C

Preferred Name

English

CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 6

Common Name

English

NON-SPECIFIC CROSSREACTING ANTIGEN

Common Name

English

NORMAL CROSS-REACTING ANTIGEN

Common Name

English

CEACAM6

Common Name

English

NCA

Common Name

English

Code System Code Type Description

SMS_ID

100000181736

Created by admin on Tue Apr 01 21:49:14 GMT 2025 , Edited by admin on Tue Apr 01 21:49:14 GMT 2025

PRIMARY

FDA UNII

YCK8BIF36J

Created by admin on Tue Apr 01 21:49:14 GMT 2025 , Edited by admin on Tue Apr 01 21:49:14 GMT 2025

PRIMARY

UNIPROT

P40199

Created by admin on Tue Apr 01 21:49:14 GMT 2025 , Edited by admin on Tue Apr 01 21:49:14 GMT 2025

PRIMARY

From	To
1_133	1_181
1_225	1_265

Glycosylation Link Type	Site
N	1_70
N	1_77
N	1_81
N	1_118
N	1_139
N	1_163
N	1_190
N	1_222
N	1_240
N	1_254
N	1_258
N	1_275

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Amount:


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Amount:


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Comments:

The proposed mechanism of action involves use of the monoclonal antibody component of the protein conjugate to target lung adenocarcinoma cells, thus delivering the urease to the tumor site. At the target site, the urease alters the pH in the local milieu, resulting in an alkalinization of the local tumor environment. In addition, the enzyme produces a high local concentration of ammonia. This combined activity leads to death of the tumor cells.

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL