Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 13:58:23 GMT 2023
by
admin
on
Sat Dec 16 13:58:23 GMT 2023
|
| Protein Sub Type | |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
YCK8BIF36J
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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YCK8BIF36J
Created by
admin on Sat Dec 16 13:58:23 GMT 2023 , Edited by admin on Sat Dec 16 13:58:23 GMT 2023
|
PRIMARY | |||
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P40199
Created by
admin on Sat Dec 16 13:58:23 GMT 2023 , Edited by admin on Sat Dec 16 13:58:23 GMT 2023
|
PRIMARY |
| From | To |
|---|---|
| 1_133 | 1_181 |
| 1_225 | 1_265 |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_70 |
| N | 1_77 |
| N | 1_81 |
| N | 1_118 |
| N | 1_139 |
| N | 1_163 |
| N | 1_190 |
| N | 1_222 |
| N | 1_240 |
| N | 1_254 |
| N | 1_258 |
| N | 1_275 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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LIGAND->TARGET | |||
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LIGAND->TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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LIGAND->TARGET |
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LIGAND->TARGET |
The proposed mechanism of action involves use of the monoclonal antibody component of the protein conjugate to target lung adenocarcinoma cells, thus delivering the urease to the tumor site. At the target site, the urease alters the pH in the local milieu, resulting in an alkalinization of the local tumor environment. In addition, the enzyme produces a high local concentration of ammonia. This combined activity leads to death of the tumor cells.
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| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT:NUMBER(CALCULATED) | CHEMICAL |
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| Molecular Formula | CHEMICAL |
|