EPIDERMAL GROWTH FACTOR RECEPTOR T790M, L858R MUTANT

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 15:05:20 GMT 2023` Edited by `admin` on `Sat Dec 16 15:05:20 GMT 2023`
Protein Type	RECEPTOR
Protein Sub Type	GROWTH FACTOR RECEPTOR
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	YA9G51KO3E
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

EPIDERMAL GROWTH FACTOR RECEPTOR T790M, L858R MUTANT

Common Name

English

EGFR T790M/L858R

Common Name

English

EGFR T790M, L858R

Common Name

English

EPIDERMAL GROWTH FACTOR RECEPTOR T790M/L858R MUTANT

Common Name

English

EGFR T790M, L858R MUTATION

Common Name

English

Code System Code Type Description

FDA UNII

YA9G51KO3E

Created by admin on Sat Dec 16 15:05:20 GMT 2023 , Edited by admin on Sat Dec 16 15:05:20 GMT 2023

PRIMARY

UNIPROT

P00533

Created by admin on Sat Dec 16 15:05:20 GMT 2023 , Edited by admin on Sat Dec 16 15:05:20 GMT 2023

PRIMARY

From	To
1_7	1_34
1_133	1_163
1_166	1_175
1_170	1_183
1_191	1_199
1_195	1_207
1_208	1_216
1_212	1_224
1_227	1_236
1_240	1_267
1_271	1_283
1_287	1_302
1_305	1_309
1_313	1_338
1_446	1_475
1_482	1_491
1_486	1_499
1_502	1_511
1_515	1_531
1_534	1_547
1_538	1_555
1_558	1_567
1_571	1_593
1_596	1_604
1_600	1_612

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_32
N	1_49
N	1_104
N	1_151
N	1_172
N	1_328
N	1_337
N	1_389
N	1_420
N	1_504
N	1_544
N	1_579
N	1_599

Related Record Type Details


					41OXH4FE7B

AV-412 FREE BASE

INHIBITOR -> TARGET

Interaction Type:

IRREVERSIBLE INHIBITOR

Qualification:

IC50

Amount:


					PA4PTH5HL9

Tigozertinib

INHIBITOR -> TARGET

Comments:

Activity against wild-type kinase 1000 fold less

Interaction Type:

IN-VITRO

Qualification:

IC50

Amount:


					Z5F65W1YAZ

IRUPLINALKIB

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					4A2Y23XK11

LAZERTINIB

INHIBITOR -> TARGET


					Z36593C4RW

TAS-121

INHIBITOR -> TARGET

Interaction Type:

IRREVERSIBLE INHIBITOR

Qualification:

IC50

Amount:


					K294YWL36N

DOSIMERTINIB

INHIBITOR -> TARGET

Comments:

Covalently and irreversibly binds to cysteine 797 in the ATP binding site of EGFR, exhibiting 200 times greater potency towards EGFRm/T790M than EGFRWT

Interaction Type:

IRREVERSIBLE INHIBITOR

Qualification:

IC50

Amount:


					HYW8DB273J

BRIGATINIB

INHIBITOR -> TARGET

Qualification:

IC50

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED)	CHEMICAL