U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 15:05:20 GMT 2023
Edited
by admin
on Sat Dec 16 15:05:20 GMT 2023
Protein Type RECEPTOR
Protein Sub Type GROWTH FACTOR RECEPTOR
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
YA9G51KO3E
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
EPIDERMAL GROWTH FACTOR RECEPTOR T790M, L858R MUTANT
Common Name English
EGFR T790M/L858R
Common Name English
EGFR T790M, L858R
Common Name English
EPIDERMAL GROWTH FACTOR RECEPTOR T790M/L858R MUTANT
Common Name English
EGFR T790M, L858R MUTATION
Common Name English
Code System Code Type Description
FDA UNII
YA9G51KO3E
Created by admin on Sat Dec 16 15:05:20 GMT 2023 , Edited by admin on Sat Dec 16 15:05:20 GMT 2023
PRIMARY
UNIPROT
P00533
Created by admin on Sat Dec 16 15:05:20 GMT 2023 , Edited by admin on Sat Dec 16 15:05:20 GMT 2023
PRIMARY
From To
1_7 1_34
1_133 1_163
1_166 1_175
1_170 1_183
1_191 1_199
1_195 1_207
1_208 1_216
1_212 1_224
1_227 1_236
1_240 1_267
1_271 1_283
1_287 1_302
1_305 1_309
1_313 1_338
1_446 1_475
1_482 1_491
1_486 1_499
1_502 1_511
1_515 1_531
1_534 1_547
1_538 1_555
1_558 1_567
1_571 1_593
1_596 1_604
1_600 1_612
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_32
N 1_49
N 1_104
N 1_151
N 1_172
N 1_328
N 1_337
N 1_389
N 1_420
N 1_504
N 1_544
N 1_579
N 1_599
Related Record Type Details
INHIBITOR -> TARGET
IRREVERSIBLE INHIBITOR
IC50
INHIBITOR -> TARGET
Activity against wild-type kinase 1000 fold less
IN-VITRO
IC50
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
IRREVERSIBLE INHIBITOR
IC50
INHIBITOR -> TARGET
Covalently and irreversibly binds to cysteine 797 in the ATP binding site of EGFR, exhibiting 200 times greater potency towards EGFRm/T790M than EGFRWT
IRREVERSIBLE INHIBITOR
IC50
INHIBITOR -> TARGET
IC50
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) CHEMICAL