Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C15H13Cl3O2 |
| Molecular Weight | 331.622 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=C(C=C1)C(C2=CC=C(O)C=C2)C(Cl)(Cl)Cl
InChI
InChIKey=BUZUQNXGKRJIJT-UHFFFAOYSA-N
InChI=1S/C15H13Cl3O2/c1-20-13-8-4-11(5-9-13)14(15(16,17)18)10-2-6-12(19)7-3-10/h2-9,14,19H,1H3
| Molecular Formula | C15H13Cl3O2 |
| Molecular Weight | 331.622 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Catalytic characteristics of CYP3A4: requirement for a phenolic function in ortho hydroxylation of estradiol and mono-O-demethylated methoxychlor. | 1997 Feb 25 |
|
| Prosubstrates of CYP3A4, the major human hepatic cytochrome P450: transformation into substrates by other P450 isoforms. | 1998 Jun 1 |
|
| Human cytochrome P450-catalyzed conversion of the proestrogenic pesticide methoxychlor into an estrogen. Role of CYP2C19 and CYP1A2 in O-demethylation. | 1998 Sep |
|
| Mechanism of induction of cytochrome p450 enzymes by the proestrogenic endocrine disruptor pesticide-methoxychlor: interactions of methoxychlor metabolites with the constitutive androstane receptor system. | 2001 Jun |
|
| Enantioselective metabolism of the endocrine disruptor pesticide methoxychlor by human cytochromes P450 (P450s): major differences in selective enantiomer formation by various P450 isoforms. | 2002 Dec |
|
| Metabolism of the endocrine disruptor pesticide-methoxychlor by human P450s: pathways involving a novel catechol metabolite. | 2002 Sep |
|
| Enantioselective recognition of mono-demethylated methoxychlor metabolites by the estrogen receptor. | 2004 Feb |
|
| Sulfonation of environmental chemicals and their metabolites in the polar bear (Ursus maritimus). | 2005 Sep |
|
| Methoxychlor metabolites may cause ovarian toxicity through estrogen-regulated pathways. | 2006 Sep |
|
| Stimulation of transactivation of the largemouth bass estrogen receptors alpha, beta-a, and beta-b by methoxychlor and its mono- and bis-demethylated metabolites in HepG2 cells. | 2008 Jan |
|
| Influence of dietary Coexposure to benzo(a)pyrene on the biotransformation and distribution of 14C-methoxychlor in the channel catfish (Ictalurus punctatus). | 2009 Apr |
|
| Mono-hydroxy methoxychlor alters levels of key sex steroids and steroidogenic enzymes in cultured mouse antral follicles. | 2010 Dec 1 |
|
| Increased sensitivity of estrogen receptor alpha overexpressing antral follicles to methoxychlor and its metabolites. | 2011 Apr |
|
| Estrogen receptor alpha overexpressing mouse antral follicles are sensitive to atresia induced by methoxychlor and its metabolites. | 2012 Jun |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:03:07 GMT 2023
by
admin
on
Sat Dec 16 05:03:07 GMT 2023
|
| Record UNII |
Y8I9CWQ645
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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DTXSID0022482
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183679
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28463-03-8
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admin on Sat Dec 16 05:03:07 GMT 2023 , Edited by admin on Sat Dec 16 05:03:07 GMT 2023
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Y8I9CWQ645
Created by
admin on Sat Dec 16 05:03:07 GMT 2023 , Edited by admin on Sat Dec 16 05:03:07 GMT 2023
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