THIAMINE TRANSPORTER 2

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 12:44:01 GMT 2023` Edited by `admin` on `Sat Dec 16 12:44:01 GMT 2023`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	Y83809589C
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

THIAMINE TRANSPORTER 2

Common Name

English

THTR-2

Common Name

English

TRANSPORT PROTEIN SLC19A3 (HUMAN)

Common Name

English

SOLUTE CARRIER FAMILY 19 MEMBER 3

Common Name

English

THTR2

Common Name

English

SLC19A3

Common Name

English

Code System Code Type Description

CAS

479887-06-4

Created by admin on Sat Dec 16 12:44:01 GMT 2023 , Edited by admin on Sat Dec 16 12:44:01 GMT 2023

ALTERNATIVE

CAS

348644-19-9

Created by admin on Sat Dec 16 12:44:01 GMT 2023 , Edited by admin on Sat Dec 16 12:44:01 GMT 2023

PRIMARY

UNIPROT

Q9BZV2

Created by admin on Sat Dec 16 12:44:01 GMT 2023 , Edited by admin on Sat Dec 16 12:44:01 GMT 2023

PRIMARY

FDA UNII

Y83809589C

Created by admin on Sat Dec 16 12:44:01 GMT 2023 , Edited by admin on Sat Dec 16 12:44:01 GMT 2023

PRIMARY

WIKIPEDIA

SLC19A3

Created by admin on Sat Dec 16 12:44:01 GMT 2023 , Edited by admin on Sat Dec 16 12:44:01 GMT 2023

PRIMARY

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_45
N	1_166

Related Record Type Details


					82S8X8XX8H

NON-INHIBITOR -> TRANSPORTER

Comments:

GREATER THAN 100 MICROMOLAR

Qualification:

IC50

Amount:


					87LA6FU830

NON-INHIBITOR -> TRANSPORTER

Qualification:

IC50

Amount:


					6L1XP550I6

INHIBITOR -> TRANSPORTER

Comments:

Patients being treated with fedratinib developed Wernicke?s encephalopathy (WE) (Sanofi, 2013), a neurological disorder linked to thiamine deficiency (Cook et al., 1998).

Qualification:

IC50

Amount:


					95CO6N199Q

AMPROLIUM

INHIBITOR -> TRANSPORTER

Qualification:

IC50

Amount:


					9100L32L2N

METFORMIN

SUBSTRATE -> TRANSPORTER

Qualification:

Km

Amount:


					X66NSO3N35

THIAMINE

SUBSTRATE -> TRANSPORTER

Comments:

thiamine uptake in the hTHTR1and hTHTR2-transfected cells were 1.85 μM and 7.29 pmol/mg protein/min, and 3.28 μM and 35.0 pmol/mg protein/min,

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED)	CHEMICAL