HMR-3787

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C41H62FN5O10
Molecular Weight	803.9569
Optical Activity	UNSPECIFIED
Defined Stereocenters	13 / 13
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@]3([H])O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@H](C)C(=O)[C@](C)(F)C(=O)O[C@H](CC)[C@@]1(C)OC(=O)N2CCCCN4C=NC5=C4N=CC=C5

InChI

InChIKey=NRYQCCZBHGMXIN-SAWHFZNOSA-N

InChI=1S/C41H62FN5O10/c1-12-29-41(8)32(47(38(52)57-41)19-14-13-18-46-22-44-27-16-15-17-43-35(27)46)25(4)30(48)23(2)21-39(6,53-11)34(26(5)33(50)40(7,42)37(51)55-29)56-36-31(49)28(45(9)10)20-24(3)54-36/h15-17,22-26,28-29,31-32,34,36,49H,12-14,18-21H2,1-11H3/t23-,24-,25+,26+,28+,29-,31-,32-,34-,36+,39-,40+,41-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C41H62FN5O10
Molecular Weight	803.9569
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	13 / 13
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:40:37 GMT 2023` Edited by `admin` on `Sat Dec 16 01:40:37 GMT 2023`
Record UNII	Y7J5Z57EM4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HMR-3787

Code

English

HMR3787

Code

English

2H-OXACYCLOTETRADECINO(4,3-D)OXAZOLE-2,6,8,14(1H,7H,9H)-TETRONE, 4-ETHYL-7-FLUOROOCTAHYDRO-1-(4-(3H-IMIDAZO(4,5-B)PYRIDIN-3-YL)BUTYL)-11-METHOXY-3A,7,9,11,13,15-HEXAMETHYL-10-((3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-.BETA.-D-XYLO-HEXOPYRANOSYL)OXY)-, (3AS,4R,7

Systematic Name

English

(1R,2R,4R,6R,7R,8R,10S,13R,14S)-7-((2S,3R,4S,6R)-4-(DIMETHYLAMINO)-3-HYDROXY-6-METHYL-TETRAHYDROPYRAN-2-YL)OXY-13-ETHYL-10-FLUORO-17-(4-IMIDAZO(4,5-B)PYRIDIN-3-YLBUTYL)-6-METHOXY-2,4,6,8,10,14-HEXAMETHYL-12,15-DIOXA-17-AZABICYCLO(12.3.0)HEPTADECANE-3,9,1

Systematic Name

English

Code System Code Type Description

PUBCHEM

6918384

Created by admin on Sat Dec 16 01:40:37 GMT 2023 , Edited by admin on Sat Dec 16 01:40:37 GMT 2023

PRIMARY

FDA UNII

Y7J5Z57EM4

Created by admin on Sat Dec 16 01:40:37 GMT 2023 , Edited by admin on Sat Dec 16 01:40:37 GMT 2023

PRIMARY

CAS

193752-39-5

Created by admin on Sat Dec 16 01:40:37 GMT 2023 , Edited by admin on Sat Dec 16 01:40:37 GMT 2023

PRIMARY

Related Record Type Details


					Y7J5Z57EM4

HMR-3787

ACTIVE MOIETY

Comments:

Telithromycin and RU 64399 were equally active against macrolide-susceptible (MICs, 0.008 to 0.06 μg/ml) and -resistantS. pyogenes isolates, but HMR 3787 had lower MICs forermB strains.