Zodasiran

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 10:41:02 GMT 2025` Edited by `admin` on `Wed Apr 02 10:41:02 GMT 2025`
Nucleic Acid Type	RNAI
Sequence Origin	SYNTHETIC
Sequence Type	COMPLETE
Record UNII	Y72TWM6CAA
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ADS-004

Preferred Name

English

Zodasiran

Official Name

English

zodasiran [INN]

Common Name

English

RNA, ([1?-de(6-amino-9H-purin-9-yl)]dA-(5??5?)-s?-Gm-Cm-Um-Cm-Am-Am-Cm-Am-(2?-deoxy-2?-fluoro)U-(2?-deoxy-2?-fluoro)A-(2?-deoxy-2?-fluoro)U-Um-Um-Gm-Am-Um-Cm-Am-Gm-Um-Am-(3??3?)-s?-[1?-de(6-amino-9H-purin-9-yl)]dA), 3?-[O-[cis-4-[(3S,8S)-17-[[2-(acetylam

Common Name

English

4-(((2R,3R)-3-(((((1R,4S)-4-(((10S,15S)-1,22-bis([(2-acetamido-2-deoxy-?-D-galactopyranosyl)oxy]-10-((2-(2-([(2-acetamido-2-deoxy-?-D-galactopyranosyl)oxy]ethoxy)ethyl)carbamoyl)-7,12,16-trioxo-3,20-dioxa-6,11,17-triazadocosan-15-yl)carbamoyl)cyclohexyl)

Common Name

English

ZODASIRAN [USAN]

Common Name

English

Code System Code Type Description

INN

12843

Created by admin on Wed Apr 02 10:41:02 GMT 2025 , Edited by admin on Wed Apr 02 10:41:02 GMT 2025

PRIMARY

FDA UNII

Y72TWM6CAA

Created by admin on Wed Apr 02 10:41:02 GMT 2025 , Edited by admin on Wed Apr 02 10:41:02 GMT 2025

PRIMARY

USAN

KL-221

Created by admin on Wed Apr 02 10:41:02 GMT 2025 , Edited by admin on Wed Apr 02 10:41:02 GMT 2025

PRIMARY

NCI_THESAURUS

C203194

Created by admin on Wed Apr 02 10:41:02 GMT 2025 , Edited by admin on Wed Apr 02 10:41:02 GMT 2025

PRIMARY

SMS_ID

300000040717

Created by admin on Wed Apr 02 10:41:02 GMT 2025 , Edited by admin on Wed Apr 02 10:41:02 GMT 2025

PRIMARY

CAS

2232918-66-8

Created by admin on Wed Apr 02 10:41:02 GMT 2025 , Edited by admin on Wed Apr 02 10:41:02 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2'-Fluoro-Ribose	1_10-1_12;2_2;2_4;2_6;2_8;2_10;2_12;2_14;2_16;2_18;2_20	13 / 44
	1_1;1_23	2 / 44
2'-O-Methyl-Ribose	1_2-1_9;1_13-1_22;2_1;2_3;2_5;2_7;2_9;2_11;2_13;2_15;2_17;2_19;2_21	29 / 44

Linkage	Site Range	Site Count
Phosphate	1_3-1_22;2_4-2_20	37 / 42
Phosporothioate	1_2;1_23;2_2-2_3;2_21	5 / 42

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