U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Wed Apr 02 08:08:08 GMT 2025
Edited
by admin
on Wed Apr 02 08:08:08 GMT 2025
Source Materials Class ORGANISM
Source Materials Type RECOMBINANT VIRUS
Source Materials State LIVE ATTENUATED GENETICALLY MODIFIED
Organism Family Arenaviridae
Infraspecific Type SUBSTRAIN
Infraspecific Name r3PICV-E7E6
Part whole
Record UNII
Y70X1GJT61
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Ninsipapogene Sibarnarepvec
USAN   INN  
Official Name English
HB-202 COMPONENT R3PICV-E7E6
Preferred Name English
Recombinant replication-competent attenuated arenavirus (Pichinde virus [PICV]) vector with two copies of the small (S) genome segment (S RNA segment) with one encoding the viral membrane glycoprotein (GP) and one encoding the viral nucleocapsid protein
Common Name English
RNA (attenuated replicating Pichinde virus vector HB-202 segment L), supramolecular complex with RNA (attenuated replicating Pichinde virus vector HB-202 segment S2 human papillomavirus 16 [24-glycine,26-glycine,91-glycine] gene E7 protein fusion protein
Common Name English
NINSIPAPOGENE SIBARNAREPVEC [USAN]
Common Name English
Code System Code Type Description
NCI_THESAURUS
C204147
Created by admin on Wed Apr 02 08:08:08 GMT 2025 , Edited by admin on Wed Apr 02 08:08:08 GMT 2025
PRIMARY
FDA UNII
Y70X1GJT61
Created by admin on Wed Apr 02 08:08:08 GMT 2025 , Edited by admin on Wed Apr 02 08:08:08 GMT 2025
PRIMARY
SMS_ID
300000026032
Created by admin on Wed Apr 02 08:08:08 GMT 2025 , Edited by admin on Wed Apr 02 08:08:08 GMT 2025
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USAN
LM-174
Created by admin on Wed Apr 02 08:08:08 GMT 2025 , Edited by admin on Wed Apr 02 08:08:08 GMT 2025
PRIMARY
CAS
2640294-04-6
Created by admin on Wed Apr 02 08:08:08 GMT 2025 , Edited by admin on Wed Apr 02 08:08:08 GMT 2025
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INN
12223
Created by admin on Wed Apr 02 08:08:08 GMT 2025 , Edited by admin on Wed Apr 02 08:08:08 GMT 2025
PRIMARY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
GENE_EXPRESSION VECTOR Pichinde virus [PICV] vector HB-202 segment L (Ninsipapogene sibarnarepvec) B7H6QP6UVF
INSERTED GENE EXPRESSION VECTOR Pichinde virus [PICV] vector HB-202 segment S-2 (Ninsipapogene sibarnarepvec) G9P78RFU5Y