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Details

Stereochemistry ACHIRAL
Molecular Formula O2Si.H2O
Molecular Weight 78.0996
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HYDRATED SILICA

SMILES

O.O=[Si]=O

InChI

InChIKey=LRCFXGAMWKDGLA-UHFFFAOYSA-N
InChI=1S/O2Si.H2O/c1-3-2;/h;1H2

HIDE SMILES / InChI

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula O2Si
Molecular Weight 60.0843
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://web.archive.org/web/20130418061428/http://www.accessdata.fda.gov/scripts/fcn/gras_notices/GRN000321.pdf

Silicon dioxide (silica) is most commonly found in nature as quartz, as well as in various living organisms. Silicon dioxide one of the most complex and most abundant families of materials, existing both as several minerals and being produced synthetically. In food and pharmaceutical industry silica is a common additive, where it is used primarily as a flow in powdered foods, or to adsorb water in hygroscopic application. In pharmaceutical products, silica aids powder flow when tablets are formed.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
Oxycodone Hydrochloride

Approved Use

Oxycodone is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

1998
Primary
Silicol gel

Approved Use

Silicol gel is an oral gel containing colloidal silicic acid for the treatment of gastrointestinal disorders. Taken 3 times a day it helps manage symptoms and provides relief for gastrointestinal discomfort.
Primary
GELUSIL

Approved Use

Uses Relieves: heartburn sour stomach acid indigestion bloating, pressure and discomfort commonly referred to as gas

Launch Date

2008
PubMed

PubMed

TitleDatePubMed
[Scleroderma and environment. I. Scleroderma and sclerodermiform states induced by silica and chemical agents or drugs].
1991
Enhanced fatty acid biosynthesis and normal surfactant secretion in hypertrophic rat type II cells.
1991 Jun
Silicate antibodies in women with silicone breast implants: development of an assay for detection of humoral immunity.
1996 Mar
Quartz exposure of the rat lung leads to a linear dose response in inflammation but not in oxidative DNA damage and mutagenicity.
2001 Apr
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis.
2003 Jun 15
Characterization of the effect of interleukin-10 on silica-induced lung fibrosis in mice.
2004 Jul
[Effect of niacin on nitric oxide synthase expression in rat lung exposed to silica].
2004 May
The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer.
2005 Jul 21
Occupational exposures and risk of systemic lupus erythematosus.
2005 Nov
Ascorbic acid-pretreated quartz enhances cyclo-oxygenase-2 expression in RAW 264.7 murine macrophages.
2007 Jan
Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: toxicity is not dependent upon particle size but on surface characteristics.
2007 Jan
Emergency room visits for respiratory conditions in children increased after Guagua Pichincha volcanic eruptions in April 2000 in Quito, Ecuador observational study: time series analysis.
2007 Jul 24
Calcitonin gene-related peptide (CGRP) as hazard marker for lung injury induced by dusts.
2007 Mar
Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles.
2007 May
Quartz inhibits glucose 6-phosphate dehydrogenase in murine alveolar macrophages.
2008 Apr
Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in a rat lung epithelial cell line.
2008 Feb 15
Macrophage responses to silica nanoparticles are highly conserved across particle sizes.
2009 Feb
Differential binding of inorganic particles to MARCO.
2009 Jan
Crystalline silica Min-U-Sil 5 induces oxidative stress in human bronchial epithelial cells BEAS-2B by reducing the efficiency of antiglycation and antioxidant enzymatic defenses.
2009 Nov 10
Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells.
2009 Oct
Inhibition of a protein tyrosine phosphatase using mesoporous oxides.
2010 Mar 11
Does vitreous silica contradict the toxicity of the crystalline silica paradigm?
2010 Mar 15
In vitro evaluation of SiC nanoparticles impact on A549 pulmonary cells: cyto-, genotoxicity and oxidative stress.
2010 Oct 20
Cytotoxicity and mitochondrial damage caused by silica nanoparticles.
2011 Dec
Surface iron inhibits quartz-induced cytotoxic and inflammatory responses in alveolar macrophages.
2011 Jan 14
TACE/TGF-α/EGFR regulates CXCL8 in bronchial epithelial cells exposed to particulate matter components.
2011 Nov
Four types of inorganic nanoparticles stimulate the inflammatory reaction in brain microglia and damage neurons in vitro.
2012 Oct 17
New insight into artifactual phenomena during in vitro toxicity assessment of engineered nanoparticles: study of TNF-α adsorption on alumina oxide nanoparticle.
2013 Apr
Toxicogenomic analysis of the particle dose- and size-response relationship of silica particles-induced toxicity in mice.
2013 Jan 11
Involvement of P2Y11 receptor in silica nanoparticles 30-induced IL-6 production by human keratinocytes.
2014 Aug 1
Inflammation and gene expression in the rat lung after instillation of silica nanoparticles: effect of size, dispersion medium and particle surface charge.
2014 Jan 3
miR-98 and its host gene Huwe1 target Caspase-3 in Silica nanoparticles-treated male germ cells.
2015 Aug 11
Role of human pulmonary fibroblast-derived MCP-1 in cell activation and migration in experimental silicosis.
2015 Oct 15
Patents

Sample Use Guides

In Vivo Use Guide
To treat gastrointestinal disorders, take one tablespoon (15ml) of silicol®gel (containing silicic acid which is a compound of silicon and oxygen) three times daily, preferably before mealtimes. After acute symptoms ease, treatment is recommended for another few days. For chronic conditions, treat for up to four weeks and then take a break to re-assess symptoms.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 13:50:09 GMT 2023
Edited
by admin
on Sat Dec 16 13:50:09 GMT 2023
Record UNII
Y6O7T4G8P9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HYDRATED SILICA
INCI  
INCI  
Official Name English
SILICIC ACID HYDRATE
Common Name English
Silicic acid [WHO-DD]
Common Name English
SILICON DIOXIDE HYDRATE
Common Name English
HYDRATED SILICA [INCI]
Common Name English
SILICA HYDRATE
Common Name English
SILICA, HYDRATED
Common Name English
SILICIC ACID [MART.]
Common Name English
SILICIC ACID [MI]
Common Name English
HYDROSILICIC ACID
Common Name English
Code System Code Type Description
DAILYMED
Y6O7T4G8P9
Created by admin on Sat Dec 16 13:50:09 GMT 2023 , Edited by admin on Sat Dec 16 13:50:09 GMT 2023
PRIMARY
FDA UNII
Y6O7T4G8P9
Created by admin on Sat Dec 16 13:50:09 GMT 2023 , Edited by admin on Sat Dec 16 13:50:09 GMT 2023
PRIMARY
ECHA (EC/EINECS)
215-683-2
Created by admin on Sat Dec 16 13:50:09 GMT 2023 , Edited by admin on Sat Dec 16 13:50:09 GMT 2023
PRIMARY
PUBCHEM
190201
Created by admin on Sat Dec 16 13:50:09 GMT 2023 , Edited by admin on Sat Dec 16 13:50:09 GMT 2023
PRIMARY
WIKIPEDIA
Silica gel
Created by admin on Sat Dec 16 13:50:09 GMT 2023 , Edited by admin on Sat Dec 16 13:50:09 GMT 2023
PRIMARY
CAS
10279-57-9
Created by admin on Sat Dec 16 13:50:09 GMT 2023 , Edited by admin on Sat Dec 16 13:50:09 GMT 2023
NON-SPECIFIC STOICHIOMETRY
MERCK INDEX
m9899
Created by admin on Sat Dec 16 13:50:09 GMT 2023 , Edited by admin on Sat Dec 16 13:50:09 GMT 2023
PRIMARY Merck Index
CAS
112926-00-8
Created by admin on Sat Dec 16 13:50:09 GMT 2023 , Edited by admin on Sat Dec 16 13:50:09 GMT 2023
ALTERNATIVE
SMS_ID
100000130350
Created by admin on Sat Dec 16 13:50:09 GMT 2023 , Edited by admin on Sat Dec 16 13:50:09 GMT 2023
PRIMARY
CAS
1343-98-2
Created by admin on Sat Dec 16 13:50:09 GMT 2023 , Edited by admin on Sat Dec 16 13:50:09 GMT 2023
PRIMARY
EVMPD
SUB42277
Created by admin on Sat Dec 16 13:50:09 GMT 2023 , Edited by admin on Sat Dec 16 13:50:09 GMT 2023
PRIMARY
Related Record Type Details
ANHYDROUS->SOLVATE
Related Record Type Details
ACTIVE MOIETY