Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | O2Si.H2O |
| Molecular Weight | 78.0996 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O=[Si]=O
InChI
InChIKey=LRCFXGAMWKDGLA-UHFFFAOYSA-N
InChI=1S/O2Si.H2O/c1-3-2;/h;1H2
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | O2Si |
| Molecular Weight | 60.0843 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including
https://web.archive.org/web/20130418061428/http://www.accessdata.fda.gov/scripts/fcn/gras_notices/GRN000321.pdf
Curator's Comment: description was created based on several sources, including
https://web.archive.org/web/20130418061428/http://www.accessdata.fda.gov/scripts/fcn/gras_notices/GRN000321.pdf
Silicon dioxide (silica) is most commonly found in nature as quartz, as well as in various living organisms. Silicon dioxide one of the most complex and most abundant families of materials, existing both as several minerals and being produced synthetically. In food and pharmaceutical industry silica is a common additive, where it is used primarily as a flow in powdered foods, or to adsorb water in hygroscopic application. In pharmaceutical products, silica aids powder flow when tablets are formed.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: Q9UEW3 Gene ID: 8685.0 Gene Symbol: MARCO Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Inactive ingredient | Oxycodone Hydrochloride Approved UseOxycodone is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics. Launch Date1998 |
|||
| Primary | Silicol gel Approved UseSilicol gel is an oral gel containing colloidal silicic acid for the treatment of gastrointestinal disorders. Taken 3 times a day it helps manage symptoms and provides relief for gastrointestinal discomfort. |
|||
| Primary | GELUSIL Approved UseUses
Relieves:
heartburn
sour stomach
acid indigestion
bloating, pressure and discomfort commonly referred to as gas Launch Date2008 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Increased expression of manganese-containing superoxide dismutase in rat lungs after inhalation of inflammatory and fibrogenic minerals. | 1994 Mar |
|
| Silicate antibodies in women with silicone breast implants: development of an assay for detection of humoral immunity. | 1996 Mar |
|
| Quartz inhibits glucose 6-phosphate dehydrogenase in murine alveolar macrophages. | 2008 Apr |
|
| Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. | 2008 Aug |
|
| Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in a rat lung epithelial cell line. | 2008 Feb 15 |
|
| Genetic polymorphisms of IL-1A, IL-1B, IL-1RN, NFKB1, FAS, and FASL, and risk of silicosis in a Chinese occupational population. | 2008 Nov |
|
| Internalization, cytotoxicity, apoptosis, and tumor necrosis factor-alpha expression in rat alveolar macrophages exposed to various dusts occurring in the ceramics industry. | 2008 Sep |
|
| Attenuation of silica-induced pulmonary fibroblasts proliferation by taurine and niacin in vitro. | 2009 Apr |
|
| Critical role of MARCO in crystalline silica-induced pulmonary inflammation. | 2009 Apr |
|
| Pulmonary toxicity of multi-walled carbon nanotubes (Baytubes) relative to alpha-quartz following a single 6h inhalation exposure of rats and a 3 months post-exposure period. | 2009 Dec 21 |
|
| Macrophage responses to silica nanoparticles are highly conserved across particle sizes. | 2009 Feb |
|
| Formation of a vitreous phase at the surface of some commercial diatomaceous earth prevents the onset of oxidative stress effects. | 2009 Jan |
|
| Differential binding of inorganic particles to MARCO. | 2009 Jan |
|
| Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro. | 2009 Jan 10 |
|
| Ascorbic acid pre-treated quartz stimulates TNF-alpha release in RAW 264.7 murine macrophages through ROS production and membrane lipid peroxidation. | 2009 Mar 19 |
|
| Cytokine and chemokine expression patterns in lung epithelial cells exposed to components characteristic of particulate air pollution. | 2009 May 2 |
|
| Crystalline silica Min-U-Sil 5 induces oxidative stress in human bronchial epithelial cells BEAS-2B by reducing the efficiency of antiglycation and antioxidant enzymatic defenses. | 2009 Nov 10 |
|
| Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells. | 2009 Oct |
|
| Oxidative stress of silica nanoparticles in human bronchial epithelial cell, Beas-2B. | 2009 Oct |
|
| Role of IL-1 beta and COX2 in silica-induced IL-6 release and loss of pneumocytes in co-cultures. | 2009 Oct |
|
| Investigation of the cytotoxic and proinflammatory effects of cement dusts in rat alveolar macrophages. | 2009 Sep |
|
| Nano-SiO2 induces apoptosis via activation of p53 and Bax mediated by oxidative stress in human hepatic cell line. | 2010 Apr |
|
| Epigenetic mediated transcriptional activation of PARP-1 participates in silica-associated malignant transformation of human bronchial epithelial cells. | 2010 Apr 1 |
|
| Airway exposure to silica-coated TiO2 nanoparticles induces pulmonary neutrophilia in mice. | 2010 Feb |
|
| IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis. | 2010 Jun 1 |
|
| Inhibition of a protein tyrosine phosphatase using mesoporous oxides. | 2010 Mar 11 |
|
| Nanotoxicity of pure silica mediated through oxidant generation rather than glutathione depletion in human lung epithelial cells. | 2010 Oct 9 |
|
| Blood gene expression profiling detects silica exposure and toxicity. | 2011 Aug |
|
| Cytotoxicity and mitochondrial damage caused by silica nanoparticles. | 2011 Dec |
|
| Platelet-derived growth factor-producing CD4+ Foxp3+ regulatory T lymphocytes promote lung fibrosis. | 2011 Dec 1 |
|
| Surface iron inhibits quartz-induced cytotoxic and inflammatory responses in alveolar macrophages. | 2011 Jan 14 |
|
| Lung fibrosis induced by crystalline silica particles is uncoupled from lung inflammation in NMRI mice. | 2011 Jun 10 |
|
| TACE/TGF-α/EGFR regulates CXCL8 in bronchial epithelial cells exposed to particulate matter components. | 2011 Nov |
|
| Altered microRNAs expression profiling in experimental silicosis rats. | 2012 |
|
| Innate immune activation by inhaled lipopolysaccharide, independent of oxidative stress, exacerbates silica-induced pulmonary fibrosis in mice. | 2012 |
|
| Transcriptomics analysis of lungs and peripheral blood of crystalline silica-exposed rats. | 2012 Aug |
|
| Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2. | 2012 Mar 1 |
|
| Four types of inorganic nanoparticles stimulate the inflammatory reaction in brain microglia and damage neurons in vitro. | 2012 Oct 17 |
|
| Implication of oxidative stress in size-dependent toxicity of silica nanoparticles in kidney cells. | 2012 Sep 28 |
|
| Activation of Egr-1 in human lung epithelial cells exposed to silica through MAPKs signaling pathways. | 2013 |
|
| Molecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats. | 2013 Apr |
|
| Transcriptional responses of human aortic endothelial cells to nanoconstructs used in biomedical applications. | 2013 Aug 5 |
|
| Cellular internalization and stress response of ingested amorphous silica nanoparticles in the midgut of Drosophila melanogaster. | 2013 Jan |
|
| Interactions of silica nanoparticles with lung epithelial cells and the association to flotillins. | 2013 Jun |
|
| Suppression of thioredoxin system contributes to silica-induced oxidative stress and pulmonary fibrogenesis in rats. | 2013 Oct 9 |
|
| Inflammation and gene expression in the rat lung after instillation of silica nanoparticles: effect of size, dispersion medium and particle surface charge. | 2014 Jan 3 |
|
| Purinergic signaling via P2X7 receptor mediates IL-1β production in Kupffer cells exposed to silica nanoparticle. | 2014 Jul 3 |
|
| Role of size and surface area for pro-inflammatory responses to silica nanoparticles in epithelial lung cells: importance of exposure conditions. | 2014 Mar |
|
| Toxicity, genotoxicity and proinflammatory effects of amorphous nanosilica in the human intestinal Caco-2 cell line. | 2015 Mar |
|
| Complex responses to Si quantum dots accumulation in carp liver tissue: Beyond oxidative stress. | 2015 Sep 5 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.silicol.co.uk/
To treat gastrointestinal disorders, take one tablespoon (15ml) of silicol®gel (containing silicic acid which is a compound of silicon and oxygen) three times daily, preferably before mealtimes. After acute symptoms ease, treatment is recommended for another few days. For chronic conditions, treat for up to four weeks and then take a break to re-assess symptoms.
Route of Administration:
Oral
| Substance Class |
Chemical
Created
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| Record UNII |
Y6O7T4G8P9
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| Record Status |
Validated (UNII)
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| Related Record | Type | Details | ||
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ANHYDROUS->SOLVATE |
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
