Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | O2Si.H2O |
| Molecular Weight | 78.0996 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O=[Si]=O
InChI
InChIKey=LRCFXGAMWKDGLA-UHFFFAOYSA-N
InChI=1S/O2Si.H2O/c1-3-2;/h;1H2
| Molecular Formula | O2Si |
| Molecular Weight | 60.0843 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including
https://web.archive.org/web/20130418061428/http://www.accessdata.fda.gov/scripts/fcn/gras_notices/GRN000321.pdf
Curator's Comment: description was created based on several sources, including
https://web.archive.org/web/20130418061428/http://www.accessdata.fda.gov/scripts/fcn/gras_notices/GRN000321.pdf
Silicon dioxide (silica) is most commonly found in nature as quartz, as well as in various living organisms. Silicon dioxide one of the most complex and most abundant families of materials, existing both as several minerals and being produced synthetically. In food and pharmaceutical industry silica is a common additive, where it is used primarily as a flow in powdered foods, or to adsorb water in hygroscopic application. In pharmaceutical products, silica aids powder flow when tablets are formed.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: Q9UEW3 Gene ID: 8685.0 Gene Symbol: MARCO Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Inactive ingredient | Oxycodone Hydrochloride Approved UseOxycodone is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics. Launch Date1998 |
|||
| Primary | Silicol gel Approved UseSilicol gel is an oral gel containing colloidal silicic acid for the treatment of gastrointestinal disorders. Taken 3 times a day it helps manage symptoms and provides relief for gastrointestinal discomfort. |
|||
| Primary | GELUSIL Approved UseUses
Relieves:
heartburn
sour stomach
acid indigestion
bloating, pressure and discomfort commonly referred to as gas Launch Date2008 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Common and distinct mechanisms of induced pulmonary fibrosis by particulate and soluble chemical fibrogenic agents. | 2016-02 |
|
| Effects of silica exposure on the cardiac and renal inflammatory and fibrotic response and the antagonistic role of interleukin-1 beta in C57BL/6 mice. | 2016-02 |
|
| Role of human pulmonary fibroblast-derived MCP-1 in cell activation and migration in experimental silicosis. | 2015-10-15 |
|
| Complex responses to Si quantum dots accumulation in carp liver tissue: Beyond oxidative stress. | 2015-09-05 |
|
| miR-98 and its host gene Huwe1 target Caspase-3 in Silica nanoparticles-treated male germ cells. | 2015-08-11 |
|
| Aberrant cytokinesis and cell fusion result in multinucleation in HepG2 cells exposed to silica nanoparticles. | 2015-03-16 |
|
| Toxicity, genotoxicity and proinflammatory effects of amorphous nanosilica in the human intestinal Caco-2 cell line. | 2015-03 |
|
| Si/SiO2 quantum dots cause cytotoxicity in lung cells through redox homeostasis imbalance. | 2014-09-05 |
|
| Uptake of silica nanoparticles: neurotoxicity and Alzheimer-like pathology in human SK-N-SH and mouse neuro2a neuroblastoma cells. | 2014-08-17 |
|
| Silica nanoparticles induce cytokine responses in lung epithelial cells through activation of a p38/TACE/TGF-α/EGFR-pathway and NF-κΒ signalling. | 2014-08-15 |
|
| Involvement of P2Y11 receptor in silica nanoparticles 30-induced IL-6 production by human keratinocytes. | 2014-08-01 |
|
| Purinergic signaling via P2X7 receptor mediates IL-1β production in Kupffer cells exposed to silica nanoparticle. | 2014-07-03 |
|
| Role of size and surface area for pro-inflammatory responses to silica nanoparticles in epithelial lung cells: importance of exposure conditions. | 2014-03 |
|
| Inflammation and gene expression in the rat lung after instillation of silica nanoparticles: effect of size, dispersion medium and particle surface charge. | 2014-01-03 |
|
| PDGF-D expression is down-regulated by TGFβ in fibroblasts. | 2014 |
|
| Neutralization of interleukin-1 beta attenuates silica-induced lung inflammation and fibrosis in C57BL/6 mice. | 2013-11 |
|
| Suppression of thioredoxin system contributes to silica-induced oxidative stress and pulmonary fibrogenesis in rats. | 2013-10-09 |
|
| Transcriptional responses of human aortic endothelial cells to nanoconstructs used in biomedical applications. | 2013-08-05 |
|
| The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells. | 2013-08 |
|
| Biological effects induced by BSA-stabilized silica nanoparticles in mammalian cell lines. | 2013-06-25 |
|
| Interactions of silica nanoparticles with lung epithelial cells and the association to flotillins. | 2013-06 |
|
| New insight into artifactual phenomena during in vitro toxicity assessment of engineered nanoparticles: study of TNF-α adsorption on alumina oxide nanoparticle. | 2013-04 |
|
| Molecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats. | 2013-04 |
|
| Comparative cytological responses of lung epithelial and pleural mesothelial cells following in vitro exposure to nanoscale SiO2. | 2013-02 |
|
| Toxicogenomic analysis of the particle dose- and size-response relationship of silica particles-induced toxicity in mice. | 2013-01-11 |
|
| Evaluation of immunohistochemical markers to detect the genotoxic mode of action of fine and ultrafine dusts in rat lungs. | 2013-01-07 |
|
| Cellular internalization and stress response of ingested amorphous silica nanoparticles in the midgut of Drosophila melanogaster. | 2013-01 |
|
| Activation of Egr-1 in human lung epithelial cells exposed to silica through MAPKs signaling pathways. | 2013 |
|
| Long-lasting oxidative pulmonary insult in rat after intratracheal instillation of silica nanoparticles doped with cadmium. | 2012-12-16 |
|
| Four types of inorganic nanoparticles stimulate the inflammatory reaction in brain microglia and damage neurons in vitro. | 2012-10-17 |
|
| Mechanisms of toxicity of amorphous silica nanoparticles on human lung submucosal cells in vitro: protective effects of fisetin. | 2012-10-15 |
|
| Implication of oxidative stress in size-dependent toxicity of silica nanoparticles in kidney cells. | 2012-09-28 |
|
| Transcriptomics analysis of lungs and peripheral blood of crystalline silica-exposed rats. | 2012-08 |
|
| Occupational and environmental cancer incidence and mortality in China. | 2012-06 |
|
| Aryl hydrocarbon receptor (AhR) regulates silica-induced inflammation but not fibrosis. | 2012-04 |
|
| Silica nanoparticles and silver-doped silica nanoparticles induce endoplasmatic reticulum stress response and alter cytochrome P4501A activity. | 2012-04 |
|
| Methylation of PARP-1 promoter involved in the regulation of nano-SiO2-induced decrease of PARP-1 mRNA expression. | 2012-03-25 |
|
| Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2. | 2012-03-01 |
|
| Immunostimulatory effects of gold nanorod and silica-coated gold nanorod on RAW 264.7 mouse macrophages. | 2012-02-25 |
|
| Altered microRNAs expression profiling in experimental silicosis rats. | 2012 |
|
| Innate immune activation by inhaled lipopolysaccharide, independent of oxidative stress, exacerbates silica-induced pulmonary fibrosis in mice. | 2012 |
|
| Platelet-derived growth factor-producing CD4+ Foxp3+ regulatory T lymphocytes promote lung fibrosis. | 2011-12-01 |
|
| Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling. | 2011-12 |
|
| Cytotoxicity and mitochondrial damage caused by silica nanoparticles. | 2011-12 |
|
| TACE/TGF-α/EGFR regulates CXCL8 in bronchial epithelial cells exposed to particulate matter components. | 2011-11 |
|
| Blood gene expression profiling detects silica exposure and toxicity. | 2011-08 |
|
| Lung fibrosis induced by crystalline silica particles is uncoupled from lung inflammation in NMRI mice. | 2011-06-10 |
|
| Surface iron inhibits quartz-induced cytotoxic and inflammatory responses in alveolar macrophages. | 2011-01-14 |
|
| Silicate antibodies in women with silicone breast implants: development of an assay for detection of humoral immunity. | 1996-03 |
|
| Increased expression of manganese-containing superoxide dismutase in rat lungs after inhalation of inflammatory and fibrogenic minerals. | 1994-03 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.silicol.co.uk/
To treat gastrointestinal disorders, take one tablespoon (15ml) of silicol®gel (containing silicic acid which is a compound of silicon and oxygen) three times daily, preferably before mealtimes. After acute symptoms ease, treatment is recommended for another few days. For chronic conditions, treat for up to four weeks and then take a break to re-assess symptoms.
Route of Administration:
Oral
| Substance Class |
Chemical
Created
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| Record UNII |
Y6O7T4G8P9
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Validated (UNII)
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Silica gel
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| Related Record | Type | Details | ||
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ANHYDROUS->SOLVATE |
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
