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Details

Stereochemistry ACHIRAL
Molecular Formula O2Si.H2O
Molecular Weight 78.0996
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HYDRATED SILICA

SMILES

O.O=[Si]=O

InChI

InChIKey=LRCFXGAMWKDGLA-UHFFFAOYSA-N
InChI=1S/O2Si.H2O/c1-3-2;/h;1H2

HIDE SMILES / InChI

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula O2Si
Molecular Weight 60.0843
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://web.archive.org/web/20130418061428/http://www.accessdata.fda.gov/scripts/fcn/gras_notices/GRN000321.pdf

Silicon dioxide (silica) is most commonly found in nature as quartz, as well as in various living organisms. Silicon dioxide one of the most complex and most abundant families of materials, existing both as several minerals and being produced synthetically. In food and pharmaceutical industry silica is a common additive, where it is used primarily as a flow in powdered foods, or to adsorb water in hygroscopic application. In pharmaceutical products, silica aids powder flow when tablets are formed.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
Oxycodone Hydrochloride

Approved Use

Oxycodone is used in the treatment of chronic pain; pain and belongs to the drug class narcotic analgesics.

Launch Date

9.0935997E11
Primary
Silicol gel

Approved Use

Silicol gel is an oral gel containing colloidal silicic acid for the treatment of gastrointestinal disorders. Taken 3 times a day it helps manage symptoms and provides relief for gastrointestinal discomfort.
Primary
GELUSIL

Approved Use

Uses Relieves: heartburn sour stomach acid indigestion bloating, pressure and discomfort commonly referred to as gas

Launch Date

1.22221442E12
PubMed

PubMed

TitleDatePubMed
Silicate antibodies in women with silicone breast implants: development of an assay for detection of humoral immunity.
1996 Mar
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis.
2003 Jun 15
Occupational exposures and risk of systemic lupus erythematosus.
2005 Nov
Ascorbic acid-pretreated quartz enhances cyclo-oxygenase-2 expression in RAW 264.7 murine macrophages.
2007 Jan
Emergency room visits for respiratory conditions in children increased after Guagua Pichincha volcanic eruptions in April 2000 in Quito, Ecuador observational study: time series analysis.
2007 Jul 24
Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles.
2007 May
Quartz inhibits glucose 6-phosphate dehydrogenase in murine alveolar macrophages.
2008 Apr
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
2008 Aug
Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in a rat lung epithelial cell line.
2008 Feb 15
Genetic polymorphisms of IL-1A, IL-1B, IL-1RN, NFKB1, FAS, and FASL, and risk of silicosis in a Chinese occupational population.
2008 Nov
Internalization, cytotoxicity, apoptosis, and tumor necrosis factor-alpha expression in rat alveolar macrophages exposed to various dusts occurring in the ceramics industry.
2008 Sep
Pulmonary toxicity of multi-walled carbon nanotubes (Baytubes) relative to alpha-quartz following a single 6h inhalation exposure of rats and a 3 months post-exposure period.
2009 Dec 21
Macrophage responses to silica nanoparticles are highly conserved across particle sizes.
2009 Feb
Differential binding of inorganic particles to MARCO.
2009 Jan
Ascorbic acid pre-treated quartz stimulates TNF-alpha release in RAW 264.7 murine macrophages through ROS production and membrane lipid peroxidation.
2009 Mar 19
Cytokine and chemokine expression patterns in lung epithelial cells exposed to components characteristic of particulate air pollution.
2009 May 2
Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells.
2009 Oct
Oxidative stress of silica nanoparticles in human bronchial epithelial cell, Beas-2B.
2009 Oct
Role of IL-1 beta and COX2 in silica-induced IL-6 release and loss of pneumocytes in co-cultures.
2009 Oct
Investigation of the cytotoxic and proinflammatory effects of cement dusts in rat alveolar macrophages.
2009 Sep
Nano-SiO2 induces apoptosis via activation of p53 and Bax mediated by oxidative stress in human hepatic cell line.
2010 Apr
Epigenetic mediated transcriptional activation of PARP-1 participates in silica-associated malignant transformation of human bronchial epithelial cells.
2010 Apr 1
Nanotoxicity of pure silica mediated through oxidant generation rather than glutathione depletion in human lung epithelial cells.
2010 Oct 9
Blood gene expression profiling detects silica exposure and toxicity.
2011 Aug
Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling.
2011 Dec
Cytotoxicity and mitochondrial damage caused by silica nanoparticles.
2011 Dec
Platelet-derived growth factor-producing CD4+ Foxp3+ regulatory T lymphocytes promote lung fibrosis.
2011 Dec 1
Surface iron inhibits quartz-induced cytotoxic and inflammatory responses in alveolar macrophages.
2011 Jan 14
Lung fibrosis induced by crystalline silica particles is uncoupled from lung inflammation in NMRI mice.
2011 Jun 10
TACE/TGF-α/EGFR regulates CXCL8 in bronchial epithelial cells exposed to particulate matter components.
2011 Nov
Innate immune activation by inhaled lipopolysaccharide, independent of oxidative stress, exacerbates silica-induced pulmonary fibrosis in mice.
2012
Aryl hydrocarbon receptor (AhR) regulates silica-induced inflammation but not fibrosis.
2012 Apr
Silica nanoparticles and silver-doped silica nanoparticles induce endoplasmatic reticulum stress response and alter cytochrome P4501A activity.
2012 Apr
Transcriptomics analysis of lungs and peripheral blood of crystalline silica-exposed rats.
2012 Aug
Immunostimulatory effects of gold nanorod and silica-coated gold nanorod on RAW 264.7 mouse macrophages.
2012 Feb 25
Occupational and environmental cancer incidence and mortality in China.
2012 Jun
Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2.
2012 Mar 1
Methylation of PARP-1 promoter involved in the regulation of nano-SiO2-induced decrease of PARP-1 mRNA expression.
2012 Mar 25
Mechanisms of toxicity of amorphous silica nanoparticles on human lung submucosal cells in vitro: protective effects of fisetin.
2012 Oct 15
Four types of inorganic nanoparticles stimulate the inflammatory reaction in brain microglia and damage neurons in vitro.
2012 Oct 17
Implication of oxidative stress in size-dependent toxicity of silica nanoparticles in kidney cells.
2012 Sep 28
New insight into artifactual phenomena during in vitro toxicity assessment of engineered nanoparticles: study of TNF-α adsorption on alumina oxide nanoparticle.
2013 Apr
Molecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats.
2013 Apr
The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells.
2013 Aug
Transcriptional responses of human aortic endothelial cells to nanoconstructs used in biomedical applications.
2013 Aug 5
Toxicogenomic analysis of the particle dose- and size-response relationship of silica particles-induced toxicity in mice.
2013 Jan 11
Biological effects induced by BSA-stabilized silica nanoparticles in mammalian cell lines.
2013 Jun 25
Neutralization of interleukin-1 beta attenuates silica-induced lung inflammation and fibrosis in C57BL/6 mice.
2013 Nov
Involvement of P2Y11 receptor in silica nanoparticles 30-induced IL-6 production by human keratinocytes.
2014 Aug 1
Complex responses to Si quantum dots accumulation in carp liver tissue: Beyond oxidative stress.
2015 Sep 5
Patents

Sample Use Guides

In Vivo Use Guide
To treat gastrointestinal disorders, take one tablespoon (15ml) of silicol®gel (containing silicic acid which is a compound of silicon and oxygen) three times daily, preferably before mealtimes. After acute symptoms ease, treatment is recommended for another few days. For chronic conditions, treat for up to four weeks and then take a break to re-assess symptoms.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sun Dec 18 13:35:06 UTC 2022
Edited
by admin
on Sun Dec 18 13:35:06 UTC 2022
Record UNII
Y6O7T4G8P9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HYDRATED SILICA
INCI  
INCI  
Official Name English
SILICIC ACID HYDRATE
Common Name English
Silicic acid [WHO-DD]
Common Name English
SILICON DIOXIDE HYDRATE
Common Name English
HYDRATED SILICA [INCI]
Common Name English
SILICA HYDRATE
Common Name English
SILICA, HYDRATED
Common Name English
SILICIC ACID [MART.]
Common Name English
SILICIC ACID [MI]
Common Name English
HYDROSILICIC ACID
Common Name English
Code System Code Type Description
DAILYMED
Y6O7T4G8P9
Created by admin on Sun Dec 18 13:35:06 UTC 2022 , Edited by admin on Sun Dec 18 13:35:06 UTC 2022
PRIMARY
FDA UNII
Y6O7T4G8P9
Created by admin on Sun Dec 18 13:35:06 UTC 2022 , Edited by admin on Sun Dec 18 13:35:06 UTC 2022
PRIMARY
ECHA (EC/EINECS)
215-683-2
Created by admin on Sun Dec 18 13:35:06 UTC 2022 , Edited by admin on Sun Dec 18 13:35:06 UTC 2022
PRIMARY
PUBCHEM
190201
Created by admin on Sun Dec 18 13:35:06 UTC 2022 , Edited by admin on Sun Dec 18 13:35:06 UTC 2022
PRIMARY
WIKIPEDIA
Silica gel
Created by admin on Sun Dec 18 13:35:06 UTC 2022 , Edited by admin on Sun Dec 18 13:35:06 UTC 2022
PRIMARY
CAS
10279-57-9
Created by admin on Sun Dec 18 13:35:06 UTC 2022 , Edited by admin on Sun Dec 18 13:35:06 UTC 2022
NON-SPECIFIC STOICHIOMETRY
MERCK INDEX
M9899
Created by admin on Sun Dec 18 13:35:06 UTC 2022 , Edited by admin on Sun Dec 18 13:35:06 UTC 2022
PRIMARY Merck Index
CAS
112926-00-8
Created by admin on Sun Dec 18 13:35:06 UTC 2022 , Edited by admin on Sun Dec 18 13:35:06 UTC 2022
ALTERNATIVE
EPA CompTox
DTXSID9029851
Created by admin on Sun Dec 18 13:35:06 UTC 2022 , Edited by admin on Sun Dec 18 13:35:06 UTC 2022
PRIMARY
CAS
1343-98-2
Created by admin on Sun Dec 18 13:35:06 UTC 2022 , Edited by admin on Sun Dec 18 13:35:06 UTC 2022
PRIMARY
EVMPD
SUB42277
Created by admin on Sun Dec 18 13:35:06 UTC 2022 , Edited by admin on Sun Dec 18 13:35:06 UTC 2022
PRIMARY
Related Record Type Details
ANHYDROUS->SOLVATE
Related Record Type Details
ACTIVE MOIETY