Adrenochrome is one of the principal oxidation products of epinephrine and has no significant pressor action. It has been studied in Europe since 1937 and in America since 1951 for its action in control of bleeding from capillaries and venules. Its role seems independent of the chemistry of coagulation, the vitamin K-prothrombin mechanism, and the function of heparin or the usual anticoagulants. It is alleged to reduce capillary permeability and to increase capillary resistance. Both natural and synthetic adrenochrome are markedly unstable and insoluble. Evolution of the adrenochrome monosemicarbazone sodium salicylate complex has overcome these chemical difficulties. This product is synthetically prepared in America under the trade name Adrenosem and the generic name of carbazochrome. The loss of blood was measured in fifty-three patients who underwent multiple extractions and alveoloplasty under general anesthesia. No local anesthetic was employed in any case. Of the fifty-three patients, twenty-six were prepared preoperatively by the intramuscular injection of 5 mg of carbazochrome (Adrenosem) salicylate one and one-half to two hours prior to the operation. The remaining twenty-seven patients served as a control group. When operations of equal extent and severity were compared, it was found that no effective benefit in reduction of loss of blood at operation was noted in the patients treated with carbazochrome salicylate.