Details
Stereochemistry | RACEMIC |
Molecular Formula | C3H6O |
Molecular Weight | 58.0791 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1CO1
InChI
InChIKey=GOOHAUXETOMSMM-UHFFFAOYSA-N
InChI=1S/C3H6O/c1-3-2-4-3/h3H,2H2,1H3
Molecular Formula | C3H6O |
Molecular Weight | 58.0791 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Propylene Oxide is a synthetic, highly-flammable, volatile, colorless liquid that is soluble in water and miscible with many organic solvents. The major use of propylene oxide is in the production of polyethers (the primary component of polyurethane foams) and propylene glycol. Propylene oxide is also used in the fumigation of foodstuffs and plastic medical instruments and in the manufacture of dipropylene glycol and glycol ethers, as herbicides, as solvents, and in the preparation of lubricants, surfactants, and oil demulsifiers. Propylene Oxide is a chiral epoxide, although it is commonly used as a racemic mixture. Acute (short-term) exposure of humans and animals to propylene oxide has caused eye and respiratory tract irritation. Dermal contact, even with dilute solutions, has caused skin irritation and necrosis in humans. Propylene oxide is also a mild central nervous system (CNS) depressant in humans. Inflammatory lesions of the nasal cavity, trachea, and lungs and neurological effects have been observed in animals chronically (long-term) exposed to propylene oxide by inhalation.
Originator
Approval Year
PubMed
Title | Date | PubMed |
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Rapid process for purification of an extracellular beta-xylosidase by aqueous two-phase extraction. | 2001 Apr 15 |
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5-acyloxy-5-hydroxymethyltetrahydro-2-furancarboxylate as a novel template for protein kinase C (PKC) binding. | 2001 Mar |
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Chiral separation of glycidyl selenide and glycidyl sulfide racemates on cellulose-based chiral stationary phases. | 2001 Sep |
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Hemoglobin adducts of ethylene oxide, propylene oxide, acrylonitrile and acrylamide-biomarkers in occupational and environmental medicine. | 2002 Aug 5 |
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Analysis of DNA and hemoglobin adducts and sister chromatid exchanges in a human population occupationally exposed to propylene oxide: a pilot study. | 2002 Mar |
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Formation of water-in-CO(2) microemulsions with non-fluorous surfactant Ls-54 and solubilization of biomacromolecules. | 2002 Mar 15 |
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Coordination chemistry and reactivity of monomeric alkoxides and amides of magnesium and zinc supported by the diiminato ligand CH(CMeNC(6)H(3)-2,6-(i)Pr(2))(2). A comparative study. | 2002 May 20 |
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Use of haemoglobin adducts in exposure monitoring and risk assessment. | 2002 Oct 5 |
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Moderation of oral bacterial adhesion on saliva-coated hydroxyapatite by polyaspartate. | 2003 |
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Correspondence re: Czene et al., Analysis of DNA and hemoglobin adducts and sister chromatid exchanges in a human population occupationally exposed to propylene oxide: a pilot study. Cancer Epidemiol. Biomark. Prev., 11: 315-318, 2002. | 2003 Apr |
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Mutagenic activity of ethylene oxide and propylene oxide under XPG proficient and deficient conditions in relation to N-7-(2-hydroxyalkyl)guanine levels in Drosophila. | 2003 Aug 28 |
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Evaluation of a novel propylene oxide-treated collagen material as a dural substitute. | 2003 Dec |
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Effects of polyether-modified poly(acrylic acid) microgels on doxorubicin transport in human intestinal epithelial Caco-2 cell layers. | 2003 Feb 14 |
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Effect of Pluronic-block copolymers on the reduction of serum-mediated inhibition of gene transfer of polyethyleneimine-DNA complexes. | 2003 Jun |
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Bacterial adherence to mucosal epithelium in the upper airways has less significance than believed. | 2003 Jun 9 |
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Preparation and characterization of biodegradable PLA polymeric blends. | 2003 Mar |
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Direct synthesis of propylene oxide with CO2 as the solvent. | 2003 Mar 10 |
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Trimethyl phosphite as a trap for alkoxy radicals formed from the ring opening of oxiranylcarbinyl radicals. Conversion to alkenes. Mechanistic applications to the study of C-C versus C-O ring cleavage. | 2003 Mar 19 |
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Serial pathways from primate prefrontal cortex to autonomic areas may influence emotional expression. | 2003 Oct 10 |
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Dosimetry by means of DNA and hemoglobin adducts in propylene oxide-exposed rats. | 2003 Sep 15 |
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Artificial carrier for oxygen supply in biological systems. | 2004 Apr |
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Core electron transitions as a probe for molecular chirality: natural circular dichroism at the carbon K-edge of methyloxirane. | 2004 Apr 14 |
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Biocatalytic resolution of glycidyl aryl ethers by Trichosporon loubierii : cell/substrate ratio influences the optical purity of (R) - epoxides. | 2004 Aug |
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Cellular and genetic analysis of wound healing in Drosophila larvae. | 2004 Aug |
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Effect of Pluronic on cellular uptake of cationic liposomes- mediated antisense oligonucleotides. | 2004 Feb |
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Absolute rate constants for reactions of tributylstannyl radicals with bromoalkanes, episulfides, and alpha-halomethyl-episulfides, -cyclopropanes, and -oxiranes: new rate expressions for sulfur and bromine atom abstraction. | 2004 Feb 20 |
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(Salen)tin complexes: syntheses, characterization, crystal structures, and catalytic activity in the formation of propylene carbonate from CO(2) and propylene oxide. | 2004 Jul 12 |
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Thermodynamics of micellization of tapered statistical copolymers of ethylene oxide and propylene oxide in water. | 2004 Jul 15 |
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Coronaviridae and SARS-associated coronavirus strain HSR1. | 2004 Mar |
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Unique reactions of glycosyl iodides with oxa- and thiocycloalkane acceptors. | 2004 Mar 18 |
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(Salen)CrIIIX catalysts for the copolymerization of carbon dioxide and epoxides: role of the initiator and cocatalyst. | 2004 Mar 22 |
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Design of a novel hydrogel-based intelligent system for controlled drug release. | 2004 Mar 24 |
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Push-pull tests for assessing in situ aerobic cometabolism. | 2004 May-Jun |
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Interaction forces between polyethylene oxide-polypropylene oxide ABA copolymers adsorbed to hydrophobic surfaces. | 2004 Sep 1 |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:02:39 GMT 2023
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on
Fri Dec 15 15:02:39 GMT 2023
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Record UNII |
Y4Y7NYD4BK
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Record Status |
Validated (UNII)
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Classification Tree | Code System | Code | ||
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IARC | Propylene oxide | ||
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NCI_THESAURUS |
C45408
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EPA PESTICIDE CODE |
42501
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Propylene oxide
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