Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H12N2O2 |
| Molecular Weight | 192.2145 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NCCC1=CNC2=C1C=C(O)C=C2O
InChI
InChIKey=LXWHQTNFZDTKBH-UHFFFAOYSA-N
InChI=1S/C10H12N2O2/c11-2-1-6-5-12-10-8(6)3-7(13)4-9(10)14/h3-5,12-14H,1-2,11H2
| Molecular Formula | C10H12N2O2 |
| Molecular Weight | 192.2145 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effects of fenfluramine on free-operant timing behaviour: evidence for involvement of 5-HT2A receptors. | 2004-11 |
|
| Serotonergic modulation in aplysia. II. Cellular and behavioral consequences of increased serotonergic tone. | 2004-10 |
|
| Serotonergic modulation in aplysia. I. Distributed serotonergic network persistently activated by sensitizing stimuli. | 2004-10 |
|
| Anxiolytic-like effects of median raphe nucleus lesion in the elevated T-maze. | 2004-08-12 |
|
| Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behavior. | 2004-07 |
|
| Fluoxetine, but not sertraline or citalopram, potentiates the locomotor stimulant effect of cocaine: possible pharmacokinetic effects. | 2004-07 |
|
| Serotonin reuptake inhibitors do not prevent 5,7-dihydroxytryptamine-induced depletion of serotonin in rat brain. | 2004-05-08 |
|
| Cognitive inflexibility after prefrontal serotonin depletion. | 2004-05-07 |
|
| ADAM is an effective tool for in vivo study of serotonergic function: validation in rat models. | 2004-05 |
|
| Influence of the corticosterone rhythm on photic entrainment of locomotor activity in rats. | 2004-04 |
|
| Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens. | 2004-03-31 |
|
| Serotonergic mechanisms of formation of emotional behavior of rats in ontogeny. | 2004-03-05 |
|
| [Delayed effects of neurotensin microinjections into the substantia nigra on conditioned motor reactions of rats with lesions to serotoninergic neurons]. | 2004-02-13 |
|
| Differential role of serotonergic projections arising from the dorsal and median raphe nuclei in locomotor hyperactivity and prepulse inhibition. | 2003-12 |
|
| Neonatal depletion of serotonin increases the numbers of callosally projecting neurons in cat visual areas 17 and 18. | 2003-11-13 |
|
| Intrathecal treatment with 6-hydroxydopamine or 5,7-dihydroxytryptamine blocks the antinociception induced by endomorphin-1 and endomorphin-2 given intracerebroventricularly in the mouse. | 2003-11 |
|
| Interaction between serotonergic and noradrenergic axons during axonal regeneration. | 2003-11 |
|
| Serotonin (5-HT) transporter (SERT) function after graded destruction of serotonergic neurons. | 2003-11 |
|
| Serotonergic regulation of the GABAergic transmission in the rat basal ganglia. | 2003-11 |
|
| Antidepressant-induced increase in high-affinity rolipram binding sites in rat brain: dependence on noradrenergic and serotonergic function. | 2003-10 |
|
| Neonatal 5-hydroxytryptamine depletion induces depressive-like behavior in adult rats. | 2003-09-18 |
|
| Cerebrospinal fluid monoamine and metabolite concentrations and aggression in rats. | 2003-09 |
|
| The dorsal raphe nucleus exerts opposed control on generalized anxiety and panic-related defensive responses in rats. | 2003-06-16 |
|
| The serotonergic modulation of synaptic plasticity in the rat hippocampo-medial prefrontal cortex pathway. | 2003-05-22 |
|
| Possible antinociceptive mechanisms of opioid receptor antagonists in the mouse formalin test. | 2003-05 |
|
| Serotonin, locomotion, exploration, and place recall in the rat. | 2003-05 |
|
| Cholinergic and serotonergic neocortical projection lesions given singly or in combination cause only mild impairments on tests of skilled movement in rats: evaluation of a model of dementia. | 2003-04-25 |
|
| Proliferative activity and nestin expression in periventricular cells of the adult rat brain. | 2003-03-24 |
|
| Serotonin-GABA interactions in the modulation of mu- and kappa-opioid analgesia. | 2003-03 |
|
| Improvement by repeated administration of 6R-tetrahydrobiopterin of 5,7-dihydroxytryptamine-induced abnormal behaviors in immature rats. | 2003-02-28 |
|
| Effect of serotonin depletion on the neuronal, endocrine and behavioural responses to corticotropin-releasing factor in the rat. | 2003-02-27 |
|
| Acute effect of simultaneous administration of tryptophan and ethanol on serotonin metabolites in the locus coeruleus in rats. | 2003-02-21 |
|
| Serotonin depletion in rat hippocampus attenuates L-NAME-induced spatial learning deficits. | 2003-02-14 |
|
| Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells. | 2003-02-07 |
|
| Mapping of neurokinin-like immunoreactivity in the human brainstem. | 2003-02-04 |
|
| Intraventricular 5,7-dihydroxytryptamine lesions disrupt acquisition of working memory task rules but not performance once learned. | 2003-02 |
|
| Behavioural and microdialysis study after neurotoxic lesion of the dorsal raphe nucleus in rats. | 2003-02 |
|
| Neurotransmitter release and its presynaptic modulation in the rat hippocampus after selective damage to cholinergic or/and serotonergic afferents. | 2003-01-30 |
|
| [Influence of neurotensin on behavior of rats with lesions in serotonergic neurons]. | 2003-01-17 |
|
| Host brain regulation of dopaminergic grafts function: role of the serotonergic and noradrenergic systems in amphetamine-induced responses. | 2003-01 |
|
| Antagonism by WAY-100635 of the effects of 8-OH-DPAT on performance on a free-operant timing schedule in intact and 5-HT-depleted rats. | 2002-12 |
|
| Destruction of serotonergic nerve terminals prevents fluoxetine-induced desensitization of hypothalamic 5-HT(1A) receptors. | 2002-12 |
|
| Dual 5-HT mechanisms in basolateral and central nuclei of amygdala in the regulation of the defensive behavior induced by electrical stimulation of the inferior colliculus. | 2002-11-30 |
|
| [125I]Epibatidine-labelled nicotinic receptors in the extended striatum and cerebral cortex: lack of association with serotonergic afferents. | 2002-11-08 |
|
| 5,7-Dihydroxytryptamine lesions enhance and serotonergic grafts normalize the evoked overflow of acetylcholine in rat hippocampal slices. | 2002-11 |
|
| Raphé grafts and 3,4-diaminopyridine-evoked overflow of serotonin in the rat hippocampus after 5,7-dihydroxytryptamine lesions: evidence for 5-HT1A autoreceptors. | 2002-10-28 |
|
| Anxiogenic effect of median raphe nucleus lesion in stressed rats. | 2002-10 |
|
| [Anxiety-like behavior in rats neonatally and adultly treated with 5,7-dihydroxytryptamine]. | 2002-10 |
|
| 5,7-Dihydroxytryptamine--a selective marker of dopaminergic or serotonergic neurons? | 2002-10 |
|
| Self-biting induced by activation of L-type calcium channels in mice: serotonergic influences. | 2002 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:53:51 GMT 2025
by
admin
on
Mon Mar 31 19:53:51 GMT 2025
|
| Record UNII |
Y4K1D1H82S
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| Record Status |
Validated (UNII)
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| Record Version |
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Y4K1D1H82S
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31363-74-3
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5,7-DIHYDROXYTRYPTAMINE
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35781
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DTXSID00185285
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250-591-6
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