5,7-DIHYDROXYTRYPTAMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H12N2O2
Molecular Weight	192.2145
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NCCC1=CNC2=C(O)C=C(O)C=C12

InChI

InChIKey=LXWHQTNFZDTKBH-UHFFFAOYSA-N

InChI=1S/C10H12N2O2/c11-2-1-6-5-12-10-8(6)3-7(13)4-9(10)14/h3-5,12-14H,1-2,11H2

HIDE SMILES / InChI

Molecular Formula	C10H12N2O2
Molecular Weight	192.2145
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Cataleptic effect of neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice: modulation by serotonergic agents.	2001 Apr 13	11292445
Functional and pharmacological characterization of the modulatory role of serotonin on the firing activity of locus coeruleus norepinephrine neurons.	2001 Dec 13	11730697
Increased m-CPP-induced oral dyskinesia after lesion of serotonergic neurons.	2001 Feb	11267640
Effects of serotonin depletion on local interneurons in the developing olfactory pathway of lobsters.	2001 Feb 15	11169505
Postnatal secretion of the subcommissural organ of the Meriones shawi: control of serotonin innervation.	2001 Jan 31	11172888
Serotonergic depletion increases conditioned suppression to background stimuli in the rat.	2001 Jun	11448092
3,4-Methylenedioxymethamphetamine induces monoamine release, but not toxicity, when administered centrally at a concentration occurring following a peripherally injected neurotoxic dose.	2001 Mar	11351932
In vivo binding properties of [carbonyl-11C]WAY-100635: effect of endogenous serotonin.	2001 May	11252023
Serotonin depletion attenuates cocaine seeking but enhances sucrose seeking and the effects of cocaine priming on reinstatement of cocaine seeking in rats.	2001 Oct	11605092
Effect of 8-OH-DPAT on temporal discrimination following central 5-hydroxytryptamine depletion.	2002 Apr	11888569
5,7-DHT-induced hippocampal 5-HT depletion attenuates behavioural deficits produced by 192 IgG-saporin lesions of septal cholinergic neurons in the rat.	2002 Jun	12099905
Alpha-7 nicotinic receptor expression by two distinct cell types in the dorsal raphe nucleus and locus coeruleus of rat.	2002 May 31	12031534
Anxiogenic effect of median raphe nucleus lesion in stressed rats.	2002 Oct	12452536
5,7-Dihydroxytryptamine--a selective marker of dopaminergic or serotonergic neurons?	2002 Oct	12237744
Mapping of neurokinin-like immunoreactivity in the human brainstem.	2003 Feb 4	12617753
The dorsal raphe nucleus exerts opposed control on generalized anxiety and panic-related defensive responses in rats.	2003 Jun 16	12798273
Serotonin-GABA interactions in the modulation of mu- and kappa-opioid analgesia.	2003 Mar	12604090
Proliferative activity and nestin expression in periventricular cells of the adult rat brain.	2003 Mar 24	12657901
Serotonin, locomotion, exploration, and place recall in the rat.	2003 May	12873630
The serotonergic modulation of synaptic plasticity in the rat hippocampo-medial prefrontal cortex pathway.	2003 May 22	12757894
Interaction between serotonergic and noradrenergic axons during axonal regeneration.	2003 Nov	14637090
Anxiolytic-like effects of median raphe nucleus lesion in the elevated T-maze.	2004 Aug 12	15219706
Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behavior.	2004 Jul	15054475
Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens.	2004 Mar 31	15056702
Serotonin reuptake inhibitors do not prevent 5,7-dihydroxytryptamine-induced depletion of serotonin in rat brain.	2004 May 8	15064132
Serotonergic modulation in aplysia. II. Cellular and behavioral consequences of increased serotonergic tone.	2004 Oct	15140904
Serotonergic modulation in aplysia. I. Distributed serotonergic network persistently activated by sensitizing stimuli.	2004 Oct	15140903

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:41:51 GMT 2023` Edited by `admin` on `Fri Dec 15 19:41:51 GMT 2023`
Record UNII	Y4K1D1H82S
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

5,7-DIHYDROXYTRYPTAMINE

Systematic Name

English

3-(2-AMINOETHYL)-1H-INDOLE-5,7-DIOL

Systematic Name

English

5,7-DHT

Common Name

English

Code System Code Type Description

FDA UNII

Y4K1D1H82S