RG-14620

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H8Cl2N2
Molecular Weight	275.133
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=CC(\C=C(/C#N)C2=CC=CN=C2)=CC(Cl)=C1

InChI

InChIKey=TYXIVBJQPBWBHO-UUILKARUSA-N

InChI=1S/C14H8Cl2N2/c15-13-5-10(6-14(16)7-13)4-12(8-17)11-2-1-3-18-9-11/h1-7,9H/b12-4+

HIDE SMILES / InChI

Molecular Formula	C14H8Cl2N2
Molecular Weight	275.133
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Epidermal growth factor receptor 49 Target ID: CHEMBL2363049 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21952748 \| https://www.ncbi.nlm.nih.gov/pubmed/1651159	Inhibitor 8504

PubMed

Title	Date	PubMed
EGFR- and AKT-mediated reduction in PTEN expression contributes to tyrphostin resistance and is reversed by mTOR inhibition in endometrial cancer cells.	2012-02	21952748
The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice.	1991-08-15	1651159

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:12:28 GMT 2025` Edited by `admin` on `Mon Mar 31 18:12:28 GMT 2025`
Record UNII	Y42W2Q9ZPP
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TYRPHOSTIN RG-14620

Preferred Name

English

RG-14620

Code

English

(Z)-A-((3,5-DICHLOROPHENYL)METHYLENE)-3-PYRIDINEACETONITRILE

Systematic Name

English

3-PYRIDINEACETONITRILE, .ALPHA.-((3,5-DICHLOROPHENYL)METHYLENE)-, (Z)-

Systematic Name

English

Code System Code Type Description

CAS

138989-57-8

Created by admin on Mon Mar 31 18:12:28 GMT 2025 , Edited by admin on Mon Mar 31 18:12:28 GMT 2025

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NCI_THESAURUS

C1667

Created by admin on Mon Mar 31 18:12:28 GMT 2025 , Edited by admin on Mon Mar 31 18:12:28 GMT 2025

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FDA UNII

Y42W2Q9ZPP

Created by admin on Mon Mar 31 18:12:28 GMT 2025 , Edited by admin on Mon Mar 31 18:12:28 GMT 2025

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PUBCHEM

5926218

Created by admin on Mon Mar 31 18:12:28 GMT 2025 , Edited by admin on Mon Mar 31 18:12:28 GMT 2025

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Related Record Type Details


					Y42W2Q9ZPP

RG-14620

ACTIVE MOIETY