Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C9H10F2N2O5 |
| Molecular Weight | 264.1829 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)C(F)(F)[C@@H]1O
InChI
InChIKey=FIRDBEQIJQERSE-QPPQHZFASA-N
InChI=1S/C9H10F2N2O5/c10-9(11)6(16)4(3-14)18-7(9)13-2-1-5(15)12-8(13)17/h1-2,4,6-7,14,16H,3H2,(H,12,15,17)/t4-,6-,7-/m1/s1
| Molecular Formula | C9H10F2N2O5 |
| Molecular Weight | 264.1829 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pharmacokinetics of intrathecal gemcitabine in nonhuman primates. | 2002 Jul |
|
| Phase I-II and pharmacokinetic study of gemcitabine combined with oxaliplatin in patients with advanced non-small-cell lung cancer and ovarian carcinoma. | 2002 Sep |
|
| Intravesical gemcitabine therapy for superficial transitional cell carcinoma of the bladder: a phase I and pharmacokinetic study. | 2003 Feb 15 |
|
| Phase I trial and pharmacokinetics of gemcitabine in children with advanced solid tumors. | 2004 Jun 15 |
|
| Intravesical gemcitabine in superficial bladder cancer: a phase II safety, efficacy and pharmacokinetic study. | 2005 May-Jun |
|
| Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits. | 2006 |
|
| High-performance liquid chromatographic method for the determination of gemcitabine and 2',2'-difluorodeoxyuridine in plasma and tissue culture media. | 2006 May 1 |
|
| Phase II study with the combination of gemcitabine and DTIC in patients with advanced soft tissue sarcomas. | 2007 Feb |
|
| New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridine. | 2008 Aug |
|
| Does saturable formation of gemcitabine triphosphate occur in patients? | 2008 Dec |
|
| Phase I clinical trial of intrathecal gemcitabine in patients with neoplastic meningitis. | 2008 Jul |
|
| Retention studies of 2'-2'-difluorodeoxycytidine and 2'-2'-difluorodeoxyuridine nucleosides and nucleotides on porous graphitic carbon: development of a liquid chromatography-tandem mass spectrometry method. | 2009 Apr 10 |
|
| Challenge of high polarity and low concentrations in analysis of cytostatics and metabolites in wastewater by hydrophilic interaction chromatography/tandem mass spectrometry. | 2009 Feb 13 |
|
| Systemic absorption and pharmacokinetics of single-dose intravesical gemcitabine after transurethral resection of the bladder in non-muscle-invasive bladder cancer. | 2009 Nov |
|
| Population pharmacokinetics of gemcitabine and its metabolite in Japanese cancer patients: impact of genetic polymorphisms. | 2010 Aug |
|
| Gemcitabine and epirubicin plasma concentration-related excretion in saliva in patients with non-small cell lung cancer. | 2010 Jun |
|
| Ecotoxicity and genotoxicity assessment of cytotoxic antineoplastic drugs and their metabolites. | 2010 Sep |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:33:15 GMT 2023
by
admin
on
Sat Dec 16 09:33:15 GMT 2023
|
| Record UNII |
Y30D8SIL1I
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
9871558
Created by
admin on Sat Dec 16 09:33:15 GMT 2023 , Edited by admin on Sat Dec 16 09:33:15 GMT 2023
|
PRIMARY | |||
|
114248-23-6
Created by
admin on Sat Dec 16 09:33:15 GMT 2023 , Edited by admin on Sat Dec 16 09:33:15 GMT 2023
|
PRIMARY | |||
|
DTXSID50891460
Created by
admin on Sat Dec 16 09:33:15 GMT 2023 , Edited by admin on Sat Dec 16 09:33:15 GMT 2023
|
PRIMARY | |||
|
Y30D8SIL1I
Created by
admin on Sat Dec 16 09:33:15 GMT 2023 , Edited by admin on Sat Dec 16 09:33:15 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
PARENT -> METABOLITE INACTIVE |
PLASMA; URINE
|
