LERONLIMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 21:24:36 GMT 2025` Edited by `admin` on `Tue Apr 01 21:24:36 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	Y1J4NP8FF0
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

leronlimab [INN]

Preferred Name

English

LERONLIMAB

Official Name

English

PRO-140

Code

English

LERONLIMAB [USAN]

Common Name

English

Leronlimab [WHO-DD]

Common Name

English

IMMUNOGLOBULIN G4-KAPPA, ANTI-(HOMO SAPIENS C-C CHEMOKINE RECEPTOR TYPE 5 (CCR5, ANTIGEN CD195))HUMANIZED MONOCLONAL ANTIBODY.GAMMA.4 HEAVY CHAIN (1-449) (HUMANIZED VH (HOMO SAPIENS IGHV3-15*06 (72%) (IGHD)-IGHJ5*01 (87%)) (8.8.15) (1-122) -HOMO SAPIENS

Systematic Name

English

IMMUNOGLOBULIN G4, ANTI-(HUMAN CHEMOKINE RECEPTOR CCR5) (HUMANIZED MONOCLONAL PRO 140 .GAMMA.4-CHAIN), DISULFIDE WITH HUMANIZED MONOCLONAL PRO 140 .KAPPA.-CHAIN, DIMER

Systematic Name

English

PRO140

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

516516

Created by admin on Tue Apr 01 21:24:36 GMT 2025 , Edited by admin on Tue Apr 01 21:24:36 GMT 2025

Code System Code Type Description

FDA UNII

Y1J4NP8FF0

Created by admin on Tue Apr 01 21:24:36 GMT 2025 , Edited by admin on Tue Apr 01 21:24:36 GMT 2025

PRIMARY

WIKIPEDIA

Leronlimab

Created by admin on Tue Apr 01 21:24:36 GMT 2025 , Edited by admin on Tue Apr 01 21:24:36 GMT 2025

PRIMARY

SMS_ID

100000181761

Created by admin on Tue Apr 01 21:24:36 GMT 2025 , Edited by admin on Tue Apr 01 21:24:36 GMT 2025

PRIMARY

CAS

674782-26-4

Created by admin on Tue Apr 01 21:24:36 GMT 2025 , Edited by admin on Tue Apr 01 21:24:36 GMT 2025

PRIMARY

INN

10751

Created by admin on Tue Apr 01 21:24:36 GMT 2025 , Edited by admin on Tue Apr 01 21:24:36 GMT 2025

PRIMARY

DRUG BANK

DB05941

Created by admin on Tue Apr 01 21:24:36 GMT 2025 , Edited by admin on Tue Apr 01 21:24:36 GMT 2025

PRIMARY

NCI_THESAURUS

C137824

Created by admin on Tue Apr 01 21:24:36 GMT 2025 , Edited by admin on Tue Apr 01 21:24:36 GMT 2025

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USAN

FG-09

Created by admin on Tue Apr 01 21:24:36 GMT 2025 , Edited by admin on Tue Apr 01 21:24:36 GMT 2025

PRIMARY

From	To
1_22	1_96
1_149	1_205
1_263	1_323
1_369	1_427
1_136	3_219
1_228	2_228
1_231	2_231
2_22	2_96
2_149	2_205
2_263	2_323
2_369	2_427
2_136	4_219
3_23	3_93
3_139	3_199
4_23	4_93
4_139	4_199

Glycosylation Link Type	Site
N	1_299
N	2_299

Related Record Type Details


					F5Q48O042G

C-C CHEMOKINE RECEPTOR TYPE 5

TARGET -> INHIBITOR

Comments:

INHIBITS HIV-1 INFECTION

Related Record Type Details


					Y1J4NP8FF0

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL