Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H4Cl4O |
| Molecular Weight | 305.972 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC2=C(C=C1Cl)C3=C(O2)C=C(Cl)C(Cl)=C3
InChI
InChIKey=KSMVNVHUTQZITP-UHFFFAOYSA-N
InChI=1S/C12H4Cl4O/c13-7-1-5-6-2-8(14)10(16)4-12(6)17-11(5)3-9(7)15/h1-4H
| Molecular Formula | C12H4Cl4O |
| Molecular Weight | 305.972 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Novel role of hnRNP-A2/B1 in modulating aryl hydrocarbon receptor ligand sensitivity. | 2015-11 |
|
| Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation. | 2015-07 |
|
| Consensus toxicity factors for polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls combining in silico models and extensive in vitro screening of AhR-mediated effects in human and rodent cells. | 2015-04-20 |
|
| Functionality of aryl hydrocarbon receptors (AhR1 and AhR2) of white sturgeon (Acipenser transmontanus) and implications for the risk assessment of dioxin-like compounds. | 2014-07-15 |
|
| Relative potency for altered humoral immunity induced by polybrominated and polychlorinated dioxins/furans in female B6C3F1/N mice. | 2014-06 |
|
| Differential relative effect potencies of some dioxin-like compounds in human peripheral blood lymphocytes and murine splenic cells. | 2014-04-07 |
|
| A genomics-based analysis of relative potencies of dioxin-like compounds in primary rat hepatocytes. | 2013-12 |
|
| Transcriptional profiles induced by the Aryl Hydrocarbon Receptor agonists 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran and 2,3,4,7,8-pentachlorodibenzofuran in primary rat hepatocytes. | 2011-09 |
|
| Differential ligand-dependent activation and a role for Y322 in aryl hydrocarbon receptor-mediated regulation of gene expression. | 2011-07-15 |
|
| Differential effects of indirubin and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the aryl hydrocarbon receptor (AhR) signalling in liver progenitor cells. | 2011-01-11 |
|
| Sensitivity of Japanese quail (Coturnix japonica), Common pheasant (Phasianus colchicus), and White Leghorn chicken (Gallus gallus domesticus) embryos to in ovo exposure to TCDD, PeCDF, and TCDF. | 2011-01 |
|
| Analysis of the CYP1A1 mRNA dose-response in human keratinocytes indicates that relative potencies of dioxins, furans, and PCBs are species and congener specific. | 2010-12 |
|
| Developing tools for risk assessment in protected species: Relative potencies inferred from competitive binding of halogenated aromatic hydrocarbons to aryl hydrocarbon receptors from beluga (Delphinapterus leucas) and mouse. | 2010-11-01 |
|
| Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran. | 2010-11 |
|
| Automated dose-response analysis and comparative toxicogenomic evaluation of the hepatic effects elicited by TCDD, TCDF, and PCB126 in C57BL/6 mice. | 2010-11 |
|
| CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor. | 2010-10 |
|
| 2,3,4,7,8-pentachlorodibenzofuran is a more potent cytochrome P4501A inducer than 2,3,7,8-tetrachlorodibenzo-p-dioxin in herring gull hepatocyte cultures. | 2010-09 |
|
| Case report: the University of Michigan dioxin exposure study: a follow-up investigation of a case with high serum concentration of 2,3,4,7,8-pentachlorodibenzofuran. | 2010-09 |
|
| Effects of in ovo exposure of white leghorn chicken, common pheasant, and Japanese quail to 2,3,7,8-tetrachlorodibenzo-p-dioxin and two chlorinated dibenzofurans on CYP1A induction. | 2010-07 |
|
| Ethoxyresorufin O-deethylase induction by TCDD, PeCDF and TCDF in ring-necked pheasant and Japanese quail hepatocytes: Time-dependent effects on concentration-response curves. | 2010-06 |
|
| Generalized concentration addition predicts joint effects of aryl hydrocarbon receptor agonists with partial agonists and competitive antagonists. | 2010-05 |
|
| Passerine exposure to primarily PCDFs and PCDDs in the river floodplains near Midland, Michigan, USA. | 2010-05 |
|
| Cytochrome P4501A induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and two chlorinated dibenzofurans in primary hepatocyte cultures of three avian species. | 2010-02 |
|
| Factorial design applied for multiple endpoint toxicity evaluation in Atlantic salmon (Salmo salar L.) hepatocytes. | 2009-12 |
|
| Automated dose-response analysis of the relative hepatic gene expression potency of TCDF in C57BL/6 mice. | 2009-11 |
|
| The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy. | 2009-09 |
|
| Hepatic P450 enzyme activity, tissue morphology and histology of mink (Mustela vison) exposed to polychlorinated dibenzofurans. | 2009-08 |
|
| The University of Michigan Dioxin Exposure Study: population survey results and serum concentrations for polychlorinated dioxins, furans, and biphenyls. | 2009-05 |
|
| Chronic effects of polychlorinated dibenzofurans on mink in laboratory and field environments. | 2009-04 |
|
| Sequencing and characterization of mixed function monooxygenase genes CYP1A1 and CYP1A2 of Mink (Mustela vison) to facilitate study of dioxin-like compounds. | 2009-02-01 |
|
| Near-ultraviolet femtosecond laser ionization of dioxins in gas chromatography/time-of-flight mass spectrometry. | 2009-01-26 |
|
| Interrelationship of Pyrogenic Polycyclic Aromatic Hydrocarbon (PAH) Contamination in Different Environmental Media. | 2009 |
|
| Nondestructive scat sampling in assessment of mink (Mustela vison) exposed to polychlorinated dibenzofurans (PCDFs). | 2008-10 |
|
| Toxicokinetics of 2,3,7,8-TCDF and 2,3,4,7,8-PeCDF in mink (Mustela vison) at ecologically relevant exposures. | 2008-09 |
|
| Evaluation of automated direct sample introduction with comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry for the screening analysis of dioxins in fish oil. | 2008-08-01 |
|
| Interlaboratory comparison of the determination of chlorinated dibenzo-p-dioxins and dibenzofurans according to regulatory methods EN 1948 and EPA 1613b. | 2008-08 |
|
| Catalytic function of avian cytochrome P450 1A4 and 1A5 (CYP1A4 and CYP1A5) enzymes heterologously expressed using in vitro yeast system. | 2008-07 |
|
| Concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs in adipose tissue of infertile men. | 2008-07 |
|
| Comparative temporal toxicogenomic analysis of TCDD- and TCDF-mediated hepatic effects in immature female C57BL/6 mice. | 2008-06 |
|
| Relative potency based on hepatic enzyme induction predicts immunosuppressive effects of a mixture of PCDDS/PCDFS and PCBS. | 2008-03-15 |
|
| Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay. | 2008-03-01 |
|
| A congener-specific survey for polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) contamination in Masan Bay, Korea. | 2007-08 |
|
| Persistent binding of ligands to the aryl hydrocarbon receptor. | 2007-07 |
|
| Molecular characterization of cytochrome P450 1A1, 1A2, and 1B1, and effects of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners on their hepatic expression in Baikal seal (Pusa sibirica). | 2007-06 |
|
| Theoretical study of structure, vibrational frequencies, and electronic spectra of dibenzofuran and its polychlorinated derivatives. | 2007-02-22 |
|
| Nonresponsiveness of normal human fibroblasts to dioxin correlates with the presence of a constitutive xenobiotic response element-binding factor. | 1993-02-25 |
|
| Serum and extracellular calcium modulate induction of cytochrome P-450IA1 in human keratinocytes. | 1990-12-05 |
|
| A competitive binding assay for 2,3,7,8-tetrachlorodibenzo-p-dioxin and related ligands of the Ah receptor. | 1988-11 |
|
| Suppression of estrogen-regulated extracellular tissue plasminogen activator activity of MCF-7 cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin. | 1987-12-01 |
|
| Ah receptor mediating induction of aryl hydrocarbon hydroxylase: detection in human lung by binding of 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin. | 1986-07 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:47:29 GMT 2025
by
admin
on
Mon Mar 31 18:47:29 GMT 2025
|
| Record UNII |
XZJ41GQI5D
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| Record Status |
Validated (UNII)
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| Record Version |
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m8954
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