NICTIAZEM

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H27N3O4S
Molecular Weight	477.575
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1)[C@@H]2SC3=CC=CC=C3N(CCN(C)C)C(=O)[C@@H]2OC(=O)C4=CC=CN=C4

InChI

InChIKey=DSYNMAGEJOOLTQ-RPWUZVMVSA-N

InChI=1S/C26H27N3O4S/c1-28(2)15-16-29-21-8-4-5-9-22(21)34-24(18-10-12-20(32-3)13-11-18)23(25(29)30)33-26(31)19-7-6-14-27-17-19/h4-14,17,23-24H,15-16H2,1-3H3/t23-,24+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C26H27N3O4S
Molecular Weight	477.575
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://books.google.ru/books?id=labzA5vOZdkC&pg=PA103&lpg=PA103&dq=NICTIAZEM retrieved from Airway Smooth Muscle: Modulation of Receptors and Response By Devendra K. Agrawal, Robert G. Townley, p. 103 | https://apps.who.int/iris/bitstream/handle/10665/275695/WHO-EMP-RHT-TSN-2018.1-eng.pdf?sequence=1&isAllowed=y | https://patents.google.com/patent/WO1993023082A1

Nictiazem, diltiazem derivative, is a calcium channel blocker. Calcium antagonists and compounds which lower intraocular pressure may be combined in ophthalmic compositions to treat glaucoma.

Approval Year

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:57:54 GMT 2023` Edited by `admin` on `Fri Dec 15 15:57:54 GMT 2023`
Record UNII	XYJ5J90IQJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NICTIAZEM

Official Name

English

(+)-CIS-5-(2-(DIMETHYLAMINO)ETHYL)-2,3-DIHYDRO-3-HYDROXY-2-(P-METHOXYPHENYL)-1,5-BENZOTHIAZEPIN-4(5H)-ONE NICOTINATE (ESTER)

Common Name

English

nictiazem [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C333