FOSFONET SODIUM ANHYDROUS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H3O5P.2Na
Molecular Weight	183.9955
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].OP([O-])(=O)CC([O-])=O

InChI

InChIKey=JBIQZGVFCHTYBY-UHFFFAOYSA-L

InChI=1S/C2H5O5P.2Na/c3-2(4)1-8(5,6)7;;/h1H2,(H,3,4)(H2,5,6,7);;/q;2*+1/p-2

HIDE SMILES / InChI

Molecular Formula	C2H3O5P
Molecular Weight	138.016
Charge	-2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7069603 | https://www.ncbi.nlm.nih.gov/pubmed/212978

Fosfonet sodium (or phosphonoacetate sodium), an organophosphorus compound, was found to be a specific inhibitor of the virus-induced DNA polymerases and thus could inhibit specifically the replication of herpes-viruses.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
DNA polymerase catalytic subunit 14 Target ID: P04293 Gene ID: 2703462.0 Gene Symbol: NA Target Organism: Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus\|\|\|1) Sources: https://www.ncbi.nlm.nih.gov/pubmed/189089 \| https://www.ncbi.nlm.nih.gov/pubmed/172657	Interacts 323

PubMed

Title	Date	PubMed
Inhibition of herpes simplex virus replication by phosphonoacetic acid.	1974 Sep	15830487
Gene amplification in fibroblasts from ataxia telangiectasia (AT) patients and in X-ray hypersensitive AT-like Chinese hamster mutants.	2001 Jan	11159752
Gene amplification and microsatellite instability induced in tumorigenic human bronchial epithelial cells by alpha particles and heavy ions.	2001 Jan	11121244
Characterization of the promoter region of the viral interferon regulatory factor encoded by Kaposi's sarcoma-associated herpesvirus.	2001 Jan 25	11313983
Tryptophan residues at subunit interfaces used as fluorescence probes to investigate homotropic and heterotropic regulation of aspartate transcarbamylase.	2001 Jul 31	11467937
Increased gene amplification in immortal rodent cells deficient for the DNA-dependent protein kinase catalytic subunit.	2001 Jun 1	11389084
A differential scanning calorimetric study of the effects of metal ions, substrate/product, substrate analogues and chaotropic anions on the thermal denaturation of yeast enolase 1.	2001 Mar 14	11251228
Varicella-zoster virus retains major histocompatibility complex class I proteins in the Golgi compartment of infected cells.	2001 May	11312359
Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins.	2002 Aug	12097601
The role of intersubunit interactions for the stabilization of the T state of Escherichia coli aspartate transcarbamoylase.	2002 Dec 20	12399459
[The effect of Kagocel on herpes virus reproduction].	2002 Jul-Aug	12271726
Solid-phase chemical synthesis of phosphonoacetate and thiophosphonoacetate oligodeoxynucleotides.	2003 Jan 29	12537492
Design and synthesis of phosphonoacetic acid (PPA) ester and amide bioisosters of ribofuranosylnucleoside diphosphates as potential ribonucleotide reductase inhibitors and evaluation of their enzyme inhibitory, cytostatic and antiviral activity.	2003 Jul	14582847
Synthesis and biological evaluation of S-acyl-3-thiopropyl prodrugs of N-phosphonoacetyl-L-aspartate (PALA).	2003 Oct	14575935
Cyclic sulfamidates as vehicles for the synthesis of substituted lactams.	2004 Dec 9	15575671
In vitro selection of drug-resistant varicella-zoster virus (VZV) mutants (OKA strain): differences between acyclovir and penciclovir?	2004 Mar	15168799
Efficient synthesis of fluorothiosparfosic acid analogues with potential antitumoral activity.	2005 Aug 15	15975800
The human cytomegalovirus UL78 gene is highly conserved among clinical isolates, but is dispensable for replication in fibroblasts and a renal artery organ-culture system.	2005 Feb	15659748
The antiviral activity of the combinations of netropsin derivatives with modified nucleosides and phosphonoacetic acid as estimated in the model of herpesvirus type 1 in a vero cell culture.	2005 Jan-Feb	15846992
Effect of ligand structure on the pathways for iron release from human serum transferrin.	2005 Jul 11	15998048
Anion binding and controlled aggregation of human interleukin-1 receptor antagonist.	2005 Jul 26	16026159
[Photodynamic inhibition of infection caused by herpes simplex virus type 1 in the cultured cells, by using 5-aminolevulinic acid-induced porphyrins].	2005 Jul-Aug	16104524
Susceptibilities of several clinical varicella-zoster virus (VZV) isolates and drug-resistant VZV strains to bicyclic furano pyrimidine nucleosides.	2005 Mar	15728906
Genomic instability in Gadd45a-/- cells is coupled with S-phase checkpoint defects.	2005 May	15846075
Precursor decomposition and nucleation kinetics during platelike apatite synthesis.	2005 Sep 15	16853209
Phosphonoacetic acid utilization by fungal isolates: occurrence and properties of a phosphonoacetate hydrolase in some penicillia.	2006 Dec	17123811
Bond strength to primed Ti-6Al-7Nb alloy of two acrylic resin adhesives.	2006 Jun	16916231
Fully stereocontrolled syntheses of 3-oxacarbacyclin and carbacyclin by the conjugate addition-azoalkene-asymmetric olefination strategy.	2006 Jun 9	16749799
Phosphonoacetate hydrolase from Penicillium oxalicum: purification and properties, phosphate starvation-independent expression, and partial sequencing.	2006 Mar	16129582
Picosecond dynamics of T and R forms of aspartate transcarbamylase: a neutron scattering study.	2006 Oct	17008138
Selective excision of chain-terminating nucleotides by HIV-1 reverse transcriptase with phosphonoformate as substrate.	2006 Sep 22	16829515
Design, synthesis, and bioactivity of novel inhibitors of E. coli aspartate transcarbamoylase.	2007 Apr 1	17336518
Glycosaminoglycan interactions in murine gammaherpesvirus-68 infection.	2007 Apr 4	17406671
Enriching suicide gene bearing tumor cells for an increased bystander effect.	2007 Jan	17024230
Autophagy suppresses tumor progression by limiting chromosomal instability.	2007 Jun 1	17510285

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:20:43 GMT 2023` Edited by `admin` on `Fri Dec 15 15:20:43 GMT 2023`
Record UNII	XWU6J9ECZA
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FOSFONET SODIUM ANHYDROUS

Common Name

English

fosfonet sodium [INN]

Common Name

English

DISODIUM PHOSPHONOACETATE

Systematic Name

English

PHOSPHONOACETIC ACID, DISODIUM SALT

Common Name

English

NSC-138745

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C29575