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COFIRASERSEN
XV92IM2BG0
Investigational
General
Record Details
Names
7
Identifiers
4
Subunits
1
Sugars
2
Linkages
1
Relationships
1
Active Moiety
1
Modifications
2
COFIRASERSEN
XV92IM2BG0
Investigational
General
Approval Year
Unknown
139,594
Record Details
Substance Class
Nucleic Acid
Nucleic Acid Type
OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Type
COMPLETE
Record UNII
XV92IM2BG0
Record Status
Validated (UNII)
Record Version
9
8
7
6
5
4
3
2
1
Names
7
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5
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entries
Name
Type
Language
Name
Type
Language
COFIRASERSEN
Official Name
English
IONIS-ENACRX
Code
English
DNA, D(P-THIO)((2'-O,4'-C-((S)-ETHYLIDENE))M5RC-(2'-O,4'-C-((S)-ETHYLIDENE))M5RC-(2'-O,4'-C-((S)-ETHYLIDENE))M5RC-G-A-T-A-G-M5C-T-G-G-T-(2'-O,4'-C-((S)-ETHYLIDENE))M5RU-(2'-O,4'-C-((S)-ETHYLIDENE))RG-(2'-O,4'-C-((S)-ETHYLIDENE))M5RU)
Common Name
English
DNA, D(P-THIO)((2',5'-ANHYDRO-6'-DEOXY-4'-C-(HYDROXYMETHYL)-.ALPHA.-L-MANNOFURANO)M5C-(3'->4')-(2',5'-ANHYDRO-6'-DEOXY-4'-C-(HYDROXYMETHYL)-.ALPHA.-L-MANNOFURANO)M5C-(3'->4')-(2',5'-ANHYDRO-6'-DEOXY-4'-C-(HYDROXYMETHYL)-.ALPHA.-L-MANNOFURANO)M5C-G-A-T-A-
Common Name
English
COFIRASERSEN [USAN]
Common Name
English
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Identifiers
4
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Code System
Code
Type
Description
Code System
Code
Type
Description
INN
11517
PRIMARY
CAS
2247669-96-9
PRIMARY
NCI_THESAURUS
C179078
PRIMARY
FDA UNII
XV92IM2BG0
PRIMARY
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Subunits
1
Sugars
2
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Sugar
Site Range
Site Count
Sugar
Site Range
Site Count
Deoxyribose (DNA)
1_4-1_13
10 / 16
2'-O,4'-ethylene bridged Ribose
1_1-1_3;1_14-1_16
6 / 16
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Linkages
1
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Linkage
Site Range
Site Count
Linkage
Site Range
Site Count
Phosporothioate
1_2-1_16
15 / 15
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Relationships
1
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Related Record
Type
Details
Related Record
Type
Details
OWX7ZO8DD9
COFIRASERSEN SODIUM
SALT/SOLVATE -> PARENT
Amount:
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Active Moiety
1
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Related Record
Type
Details
Related Record
Type
Details
XV92IM2BG0
COFIRASERSEN
ACTIVE MOIETY
Amount:
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Modifications
2
Structural Modifications
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Modification Type
Location Site
Location Type
Residue Modified
Extent
Fragment Name
Fragment Approval
Modification Type
Location Site
Location Type
Residue Modified
Extent
Fragment Name
Fragment Approval
NUCLEOSIDE BASE SUBSTITUTION
[1_14] [1_16]
THYMINE
QR26YLT7LT
NUCLEOSIDE BASE SUBSTITUTION
[1_1] [1_2] [1_3] [1_9]
5-METHYLCYTOSINE
6R795CQT4H
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