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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 15:58:41 GMT 2025
Edited
by admin
on Wed Apr 02 15:58:41 GMT 2025
Protein Type MONOCLONAL ANTIBODY AND PEPTIDE FUSION PROTEIN
Protein Sub Type IGG1
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
XPV3BT6FPY
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RG-6979
Preferred Name English
Eciskafusp alfa
USAN   INN  
Official Name English
eciskafusp alfa [INN]
Common Name English
ECISKAFUSP ALFA [USAN]
Common Name English
RO-7284755
Code English
humanized immunoglobulin G1-kappa, anti-[Homo sapiens PDCD1 (programmed cell death protein 1, PD-1, PD1, CD279)], fused at the C-terminus of one heavy chain, via a (G4S)3 peptide linker with one interleukin 2 mutant chain, glycoform alfa: gamma1 heavy ch
Common Name English
RO7284755
Code English
Immunoglobulin G1 [237-alanine,238-alanine,332-glycine,357-cysteine,369-tryptophan,de-450-lysine], anti-(human programmed cell death protein 1) (human-Mus musculus ?1-chain) fusion protein with peptide linker (GGGGS)3 fusion protein with interleukin 2 [3
Common Name English
Eciskafusp alfa [WHO-DD]
Common Name English
RG6979
Code English
Code System Code Type Description
CAS
2649758-52-9
Created by admin on Wed Apr 02 15:58:41 GMT 2025 , Edited by admin on Wed Apr 02 15:58:41 GMT 2025
PRIMARY
SMS_ID
300000010420
Created by admin on Wed Apr 02 15:58:41 GMT 2025 , Edited by admin on Wed Apr 02 15:58:41 GMT 2025
PRIMARY
NCI_THESAURUS
C175945
Created by admin on Wed Apr 02 15:58:41 GMT 2025 , Edited by admin on Wed Apr 02 15:58:41 GMT 2025
PRIMARY
FDA UNII
XPV3BT6FPY
Created by admin on Wed Apr 02 15:58:41 GMT 2025 , Edited by admin on Wed Apr 02 15:58:41 GMT 2025
PRIMARY
INN
12317
Created by admin on Wed Apr 02 15:58:41 GMT 2025 , Edited by admin on Wed Apr 02 15:58:41 GMT 2025
PRIMARY
USAN
LM-168
Created by admin on Wed Apr 02 15:58:41 GMT 2025 , Edited by admin on Wed Apr 02 15:58:41 GMT 2025
PRIMARY
From To
1_22 1_96
1_428 1_522
1_569 2_22
2_96 4_23
2_223 2_229
1_147 1_203
2_232 2_264
2_324 2_352
2_370 2_428
3_92 3_138
3_198 3_218
1_223 3_23
1_229 2_147
1_232 2_203
1_264 1_324
1_357 1_370
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_300
N 2_300
Related Record Type Details
PROGRAMMED CELL DEATH PROTEIN 1
TARGET->LIGAND
Related Record Type Details
Eciskafusp alfa
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID REMOVAL [2_450] C-TERMINUS LYSINE K3Z4F929H6
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
NCATS
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