U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Nucleic Acid
Created
by admin
on Sat Dec 16 19:03:29 GMT 2023
Edited
by admin
on Sat Dec 16 19:03:29 GMT 2023
Nucleic Acid Type RNAI
Nucleic Acid Subtype
Sequence Type COMPLETE
Record UNII
XG9ARL6P25
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Plozasiran
USAN  
Official Name English
ADS-005 FREE ACID
Code English
PLOZASIRAN [USAN]
Common Name English
all-P-ambo-(3'→5')-2'-O-Methyluridylyl-(3'→5')-2'-deoxy-2'-fluoroguanylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-deoxy-2'-fluorocytidylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')
Systematic Name English
RNA, ([1′-de(6-amino-9H-purin-9-yl)]dA-(5′→5′)-sp-Am-Cm-Gm-Gm-Gm-Am-Cm-Am-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)A-Um-Um-Cm-Um-Cm-Am-Gm-Um-Im-Am-(3′→3′)-sp-[1′-de(6-amino-9H-purin-9-yl)]dA), 3′-[O-[c
Systematic Name English
Code System Code Type Description
FDA UNII
XG9ARL6P25
Created by admin on Sat Dec 16 19:03:29 GMT 2023 , Edited by admin on Sat Dec 16 19:03:29 GMT 2023
PRIMARY
INN
13041
Created by admin on Sat Dec 16 19:03:29 GMT 2023 , Edited by admin on Sat Dec 16 19:03:29 GMT 2023
PRIMARY
CAS
2379776-40-4
Created by admin on Sat Dec 16 19:03:29 GMT 2023 , Edited by admin on Sat Dec 16 19:03:29 GMT 2023
PRIMARY
USAN
KL-219
Created by admin on Sat Dec 16 19:03:29 GMT 2023 , Edited by admin on Sat Dec 16 19:03:29 GMT 2023
PRIMARY
Sugar Site Range Site Count
2'-Fluoro-Ribose 1_10-1_12;2_2;2_4;2_12;2_14;2_16;2_18;2_20 10 / 44
2'-O-Methyl-Ribose 1_1-1_9;1_13-1_23;2_1;2_3;2_5-2_11;2_13;2_15;2_17;2_19;2_21 34 / 44
Linkage Site Range Site Count
Phosphate 1_2-1_21;1_23;2_3;2_5-2_20 38 / 42
Phosporothioate 1_22;2_2;2_4;2_21 4 / 42
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
NUCLEOTIDE SUBSTITUTION [1_23] 1,2-DIDEOXY-D-RIBOFURANOSE 3'-PHOSPHOROTHIOATE EKE4PS2PRF
NUCLEOTIDE SUBSTITUTION [1_1] UNSPECIFIED SUBSTANCE
cfd6533c
(not in database)
NUCLEOSIDE BASE SUBSTITUTION [1_21] SITE_SPECIFIC HYPOXANTHINE 2TN51YD919