Plozasiran

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 19:03:29 GMT 2023` Edited by `admin` on `Sat Dec 16 19:03:29 GMT 2023`
Nucleic Acid Type	RNAI
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	XG9ARL6P25
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Plozasiran

Official Name

English

ADS-005 FREE ACID

Code

English

PLOZASIRAN [USAN]

Common Name

English

all-P-ambo-(3'→5')-2'-O-Methyluridylyl-(3'→5')-2'-deoxy-2'-fluoroguanylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-deoxy-2'-fluorocytidylyl-(3'→5')-2'-O-methylcytidylyl-(3'→5')-2'-deoxy-2'-fluorouridylyl-(3'→5')-2'-O-methylguanylyl-(3'→5')

Systematic Name

English

RNA, ([1′-de(6-amino-9H-purin-9-yl)]dA-(5′→5′)-sp-Am-Cm-Gm-Gm-Gm-Am-Cm-Am-(2′-deoxy-2′-fluoro)G-(2′-deoxy-2′-fluoro)U-(2′-deoxy-2′-fluoro)A-Um-Um-Cm-Um-Cm-Am-Gm-Um-Im-Am-(3′→3′)-sp-[1′-de(6-amino-9H-purin-9-yl)]dA), 3′-[O-[c

Systematic Name

English

Code System Code Type Description

FDA UNII

XG9ARL6P25

Created by admin on Sat Dec 16 19:03:29 GMT 2023 , Edited by admin on Sat Dec 16 19:03:29 GMT 2023

PRIMARY

INN

13041

Created by admin on Sat Dec 16 19:03:29 GMT 2023 , Edited by admin on Sat Dec 16 19:03:29 GMT 2023

PRIMARY

CAS

2379776-40-4

Created by admin on Sat Dec 16 19:03:29 GMT 2023 , Edited by admin on Sat Dec 16 19:03:29 GMT 2023

PRIMARY

USAN

KL-219

Created by admin on Sat Dec 16 19:03:29 GMT 2023 , Edited by admin on Sat Dec 16 19:03:29 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
2'-Fluoro-Ribose	1_10-1_12;2_2;2_4;2_12;2_14;2_16;2_18;2_20	10 / 44
2'-O-Methyl-Ribose	1_1-1_9;1_13-1_23;2_1;2_3;2_5-2_11;2_13;2_15;2_17;2_19;2_21	34 / 44

Linkage	Site Range	Site Count
Phosphate	1_2-1_21;1_23;2_3;2_5-2_20	38 / 42
Phosporothioate	1_22;2_2;2_4;2_21	4 / 42

Related Record Type Details


					XG9ARL6P25

Plozasiran

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_23]		1,2-DIDEOXY-D-RIBOFURANOSE 3'-PHOSPHOROTHIOATE	EKE4PS2PRF
NUCLEOTIDE SUBSTITUTION	[1_1]		UNSPECIFIED SUBSTANCE	cfd6533c (not in database)
NUCLEOSIDE BASE SUBSTITUTION	[1_21]	SITE_SPECIFIC	HYPOXANTHINE	2TN51YD919